Prevalence of metabolic syndrome with different serum vitamin D levels in middle-aged and older adults
Abstract Background The relationship between serum vitamin D levels and metabolic syndrome (MetS) has been controversial. This study focused on the relationship between the prevalence of MetS and serum vitamin D levels in middle-aged and elderly people. Methods This study included middle-aged and ol...
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BMC
2025-01-01
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| Series: | Nutrition & Metabolism |
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| Online Access: | https://doi.org/10.1186/s12986-024-00889-7 |
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| author | Ya Zhao Danting Su Lichun Huang Mengjie He Dan Han Dong Zhao Yan Zou Ronghua Zhang |
| author_facet | Ya Zhao Danting Su Lichun Huang Mengjie He Dan Han Dong Zhao Yan Zou Ronghua Zhang |
| author_sort | Ya Zhao |
| collection | DOAJ |
| description | Abstract Background The relationship between serum vitamin D levels and metabolic syndrome (MetS) has been controversial. This study focused on the relationship between the prevalence of MetS and serum vitamin D levels in middle-aged and elderly people. Methods This study included middle-aged and older adults who participated in the 2023 Zhejiang Provincial Nutrition and Health Survey, which was conducted in 90 districts and counties in Zhejiang Province, China. Results A total of 11,305 participants were included in this study. MetS was prevalent in 31.7% of participants. Vitamin D and vitamin D3 concentrations were inversely associated with MetS prevalence (P trend<0.05), but not with vitamin D2, regardless of whether logistic regression models were adjusted for confounding factors. After adjusting for age, sex, physical activity level, smoking status, education level, annual per capita household income, and body mass index residuals, the highest tertile (Q3) of vitamin D (odds ratio [OR], 0.779; 95% confidence interval [CI], 0.702–0.865) and vitamin D3 (OR, 0.787; 95% CI, 0.709–0.875) concentrations had a lower risk of MetS than the lowest tertile (Q1). We found that vitamin D and D3 levels were correlated with age (P interaction<0.05). When age-stratified analyses were performed, vitamin D and vitamin D3 levels were significantly negatively associated with MetS in older adults but not in middle-aged adults. Conclusions Low total serum vitamin D and vitamin D3 levels were associated with a higher risk of MetS in adults aged 60 years and older. |
| format | Article |
| id | doaj-art-ce7a1f8f72e64e6c84087494b7062570 |
| institution | Kabale University |
| issn | 1743-7075 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | Nutrition & Metabolism |
| spelling | doaj-art-ce7a1f8f72e64e6c84087494b70625702025-01-26T12:18:35ZengBMCNutrition & Metabolism1743-70752025-01-012211710.1186/s12986-024-00889-7Prevalence of metabolic syndrome with different serum vitamin D levels in middle-aged and older adultsYa Zhao0Danting Su1Lichun Huang2Mengjie He3Dan Han4Dong Zhao5Yan Zou6Ronghua Zhang7School of Public Health, Hangzhou Medical CollegeZhejiang Provincial Center for Disease Control and PreventionZhejiang Provincial Center for Disease Control and PreventionZhejiang Provincial Center for Disease Control and PreventionZhejiang Provincial Center for Disease Control and PreventionZhejiang Provincial Center for Disease Control and PreventionZhejiang Provincial Center for Disease Control and PreventionZhejiang Provincial Center for Disease Control and PreventionAbstract Background The relationship between serum vitamin D levels and metabolic syndrome (MetS) has been controversial. This study focused on the relationship between the prevalence of MetS and serum vitamin D levels in middle-aged and elderly people. Methods This study included middle-aged and older adults who participated in the 2023 Zhejiang Provincial Nutrition and Health Survey, which was conducted in 90 districts and counties in Zhejiang Province, China. Results A total of 11,305 participants were included in this study. MetS was prevalent in 31.7% of participants. Vitamin D and vitamin D3 concentrations were inversely associated with MetS prevalence (P trend<0.05), but not with vitamin D2, regardless of whether logistic regression models were adjusted for confounding factors. After adjusting for age, sex, physical activity level, smoking status, education level, annual per capita household income, and body mass index residuals, the highest tertile (Q3) of vitamin D (odds ratio [OR], 0.779; 95% confidence interval [CI], 0.702–0.865) and vitamin D3 (OR, 0.787; 95% CI, 0.709–0.875) concentrations had a lower risk of MetS than the lowest tertile (Q1). We found that vitamin D and D3 levels were correlated with age (P interaction<0.05). When age-stratified analyses were performed, vitamin D and vitamin D3 levels were significantly negatively associated with MetS in older adults but not in middle-aged adults. Conclusions Low total serum vitamin D and vitamin D3 levels were associated with a higher risk of MetS in adults aged 60 years and older.https://doi.org/10.1186/s12986-024-00889-7Metabolic syndromeMiddle-aged adultsOlder adultsSerum vitamin D |
| spellingShingle | Ya Zhao Danting Su Lichun Huang Mengjie He Dan Han Dong Zhao Yan Zou Ronghua Zhang Prevalence of metabolic syndrome with different serum vitamin D levels in middle-aged and older adults Nutrition & Metabolism Metabolic syndrome Middle-aged adults Older adults Serum vitamin D |
| title | Prevalence of metabolic syndrome with different serum vitamin D levels in middle-aged and older adults |
| title_full | Prevalence of metabolic syndrome with different serum vitamin D levels in middle-aged and older adults |
| title_fullStr | Prevalence of metabolic syndrome with different serum vitamin D levels in middle-aged and older adults |
| title_full_unstemmed | Prevalence of metabolic syndrome with different serum vitamin D levels in middle-aged and older adults |
| title_short | Prevalence of metabolic syndrome with different serum vitamin D levels in middle-aged and older adults |
| title_sort | prevalence of metabolic syndrome with different serum vitamin d levels in middle aged and older adults |
| topic | Metabolic syndrome Middle-aged adults Older adults Serum vitamin D |
| url | https://doi.org/10.1186/s12986-024-00889-7 |
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