Anal gland adenocarcinoma in situ with pagetoid spread: a case report
Abstract Background Anal gland carcinoma with perianal Paget’s disease is rare, and anal gland carcinoma in situ is extremely rare. No cases of anal gland carcinoma in situ with pagetoid spread have been previously reported. Case presentation Physical examination in a 75-year-old woman revealed an e...
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Japan Surgical Society
2018-06-01
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| Series: | Surgical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40792-018-0469-5 |
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| author | Kohei Ishioka Fumikazu Koyama Hiroyuki Kuge Takashi Inoue Shinsaku Obara Takayuki Nakamoto Yoshiyuki Sasaki Yasuyuki Nakamura Maiko Takeda Chiho Ohbayashi Masamitsu Kuwahara Masayuki Sho |
| author_facet | Kohei Ishioka Fumikazu Koyama Hiroyuki Kuge Takashi Inoue Shinsaku Obara Takayuki Nakamoto Yoshiyuki Sasaki Yasuyuki Nakamura Maiko Takeda Chiho Ohbayashi Masamitsu Kuwahara Masayuki Sho |
| author_sort | Kohei Ishioka |
| collection | DOAJ |
| description | Abstract Background Anal gland carcinoma with perianal Paget’s disease is rare, and anal gland carcinoma in situ is extremely rare. No cases of anal gland carcinoma in situ with pagetoid spread have been previously reported. Case presentation Physical examination in a 75-year-old woman revealed an erythematous, inflamed, perianal skin lesion. Neither colposcopy, cystoscopy, colonoscopy, computed tomography, nor magnetic resonance imaging showed evidence of malignant genitourinary or gastrointestinal lesions. Histopathological examination of a biopsy specimen showed many Paget’s cells in the perianal skin lesion and no malignant cells in the rectal or vaginal mucosa. Therefore, primary extramammary Paget’s disease of the anogenital region was suspected, and we performed anus-preserving wide local excision. However, immunohistochemistry revealed a diagnosis of secondary extramammary Paget’s disease due to adenocarcinoma arising from the anal gland. We therefore proceeded with a radical operation. Histopathological examination showed no residual cancer cells. The final diagnosis was anal gland adenocarcinoma in situ with pagetoid spread in the perianal skin. Conclusions This is the first case report of anal gland adenocarcinoma in situ with pagetoid spread. We recommend immunohistochemical analysis of biopsy and locally resected specimens to obtain an accurate diagnosis and determine the appropriate treatment when there is no visible tumor. |
| format | Article |
| id | doaj-art-ce79d889b754490386bcbb7e3304f7e5 |
| institution | Kabale University |
| issn | 2198-7793 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-ce79d889b754490386bcbb7e3304f7e52025-08-20T03:57:44ZengJapan Surgical SocietySurgical Case Reports2198-77932018-06-01411510.1186/s40792-018-0469-5Anal gland adenocarcinoma in situ with pagetoid spread: a case reportKohei Ishioka0Fumikazu Koyama1Hiroyuki Kuge2Takashi Inoue3Shinsaku Obara4Takayuki Nakamoto5Yoshiyuki Sasaki6Yasuyuki Nakamura7Maiko Takeda8Chiho Ohbayashi9Masamitsu Kuwahara10Masayuki Sho11Department of Surgery, Nara Medical UniversityDepartment of Surgery, Nara Medical UniversityDepartment of Surgery, Nara Medical UniversityDepartment of Surgery, Nara Medical UniversityDepartment of Surgery, Nara Medical UniversityDepartment of Surgery, Nara Medical UniversityDepartment of Surgery, Nara Medical UniversityDepartment of Surgery, Nara Medical UniversityDepartment of Diagnostic Pathology, Nara Medical UniversityDepartment of Diagnostic Pathology, Nara Medical UniversityDepartment of Plastic Surgery, Nara Medical UniversityDepartment of Surgery, Nara Medical UniversityAbstract Background Anal gland carcinoma with perianal Paget’s disease is rare, and anal gland carcinoma in situ is extremely rare. No cases of anal gland carcinoma in situ with pagetoid spread have been previously reported. Case presentation Physical examination in a 75-year-old woman revealed an erythematous, inflamed, perianal skin lesion. Neither colposcopy, cystoscopy, colonoscopy, computed tomography, nor magnetic resonance imaging showed evidence of malignant genitourinary or gastrointestinal lesions. Histopathological examination of a biopsy specimen showed many Paget’s cells in the perianal skin lesion and no malignant cells in the rectal or vaginal mucosa. Therefore, primary extramammary Paget’s disease of the anogenital region was suspected, and we performed anus-preserving wide local excision. However, immunohistochemistry revealed a diagnosis of secondary extramammary Paget’s disease due to adenocarcinoma arising from the anal gland. We therefore proceeded with a radical operation. Histopathological examination showed no residual cancer cells. The final diagnosis was anal gland adenocarcinoma in situ with pagetoid spread in the perianal skin. Conclusions This is the first case report of anal gland adenocarcinoma in situ with pagetoid spread. We recommend immunohistochemical analysis of biopsy and locally resected specimens to obtain an accurate diagnosis and determine the appropriate treatment when there is no visible tumor.http://link.springer.com/article/10.1186/s40792-018-0469-5Anal gland adenocarcinomaAdenocarcinoma in situPerianal Paget’s disease |
| spellingShingle | Kohei Ishioka Fumikazu Koyama Hiroyuki Kuge Takashi Inoue Shinsaku Obara Takayuki Nakamoto Yoshiyuki Sasaki Yasuyuki Nakamura Maiko Takeda Chiho Ohbayashi Masamitsu Kuwahara Masayuki Sho Anal gland adenocarcinoma in situ with pagetoid spread: a case report Surgical Case Reports Anal gland adenocarcinoma Adenocarcinoma in situ Perianal Paget’s disease |
| title | Anal gland adenocarcinoma in situ with pagetoid spread: a case report |
| title_full | Anal gland adenocarcinoma in situ with pagetoid spread: a case report |
| title_fullStr | Anal gland adenocarcinoma in situ with pagetoid spread: a case report |
| title_full_unstemmed | Anal gland adenocarcinoma in situ with pagetoid spread: a case report |
| title_short | Anal gland adenocarcinoma in situ with pagetoid spread: a case report |
| title_sort | anal gland adenocarcinoma in situ with pagetoid spread a case report |
| topic | Anal gland adenocarcinoma Adenocarcinoma in situ Perianal Paget’s disease |
| url | http://link.springer.com/article/10.1186/s40792-018-0469-5 |
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