Long-Term Remission of Primary Bone Marrow Diffuse Large B-Cell Lymphoma Treated with High-Dose Chemotherapy Rescued by In Vivo Rituximab-Purged Autologous Stem Cells
Primary bone marrow diffuse large B-cell lymphoma (DLBCL) is a rare type of extranodal lymphoma with poor prognosis. Here, we report a case of primary bone marrow DLBCL successfully treated with high-dose chemotherapy and rescued by in vivo rituximab-purged autologous stem cells. A 39-year-old woman...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/957063 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849695852779536384 |
|---|---|
| author | Hiroshi Kazama Masanao Teramura Kentaro Yoshinaga Akihiro Masuda Toshiko Motoji |
| author_facet | Hiroshi Kazama Masanao Teramura Kentaro Yoshinaga Akihiro Masuda Toshiko Motoji |
| author_sort | Hiroshi Kazama |
| collection | DOAJ |
| description | Primary bone marrow diffuse large B-cell lymphoma (DLBCL) is a rare type of extranodal lymphoma with poor prognosis. Here, we report a case of primary bone marrow DLBCL successfully treated with high-dose chemotherapy and rescued by in vivo rituximab-purged autologous stem cells. A 39-year-old woman visited our hospital because of anemia. Bone marrow examination revealed a large B-cell lymphoma invasion. An 18F-fluorodeoxyglucose positron emission tomography scan revealed disseminated bone marrow uptake without evidence of dissemination at other sites. These findings led to a diagnosis of primary bone marrow DLBCL. Our patient underwent R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) chemotherapy and achieved complete remission. Subsequently, she received high-dose chemotherapy with an in vivo rituximab-purged autologous stem cell transplant. Seven years have passed since the transplantation, and she remains in remission. This suggests that transplantation of an in vivo rituximab-purged autograft is a promising strategy for primary bone marrow DLBCL. |
| format | Article |
| id | doaj-art-ce73eaa5c5e24b59990014b20ab6da2e |
| institution | DOAJ |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-ce73eaa5c5e24b59990014b20ab6da2e2025-08-20T03:19:38ZengWileyCase Reports in Medicine1687-96271687-96352012-01-01201210.1155/2012/957063957063Long-Term Remission of Primary Bone Marrow Diffuse Large B-Cell Lymphoma Treated with High-Dose Chemotherapy Rescued by In Vivo Rituximab-Purged Autologous Stem CellsHiroshi Kazama0Masanao Teramura1Kentaro Yoshinaga2Akihiro Masuda3Toshiko Motoji4Department of Hematology, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, JapanDepartment of Hematology, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, JapanDepartment of Hematology, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, JapanDepartment of Surgical Pathology, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, JapanDepartment of Hematology, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, JapanPrimary bone marrow diffuse large B-cell lymphoma (DLBCL) is a rare type of extranodal lymphoma with poor prognosis. Here, we report a case of primary bone marrow DLBCL successfully treated with high-dose chemotherapy and rescued by in vivo rituximab-purged autologous stem cells. A 39-year-old woman visited our hospital because of anemia. Bone marrow examination revealed a large B-cell lymphoma invasion. An 18F-fluorodeoxyglucose positron emission tomography scan revealed disseminated bone marrow uptake without evidence of dissemination at other sites. These findings led to a diagnosis of primary bone marrow DLBCL. Our patient underwent R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) chemotherapy and achieved complete remission. Subsequently, she received high-dose chemotherapy with an in vivo rituximab-purged autologous stem cell transplant. Seven years have passed since the transplantation, and she remains in remission. This suggests that transplantation of an in vivo rituximab-purged autograft is a promising strategy for primary bone marrow DLBCL.http://dx.doi.org/10.1155/2012/957063 |
| spellingShingle | Hiroshi Kazama Masanao Teramura Kentaro Yoshinaga Akihiro Masuda Toshiko Motoji Long-Term Remission of Primary Bone Marrow Diffuse Large B-Cell Lymphoma Treated with High-Dose Chemotherapy Rescued by In Vivo Rituximab-Purged Autologous Stem Cells Case Reports in Medicine |
| title | Long-Term Remission of Primary Bone Marrow Diffuse Large B-Cell Lymphoma Treated with High-Dose Chemotherapy Rescued by In Vivo Rituximab-Purged Autologous Stem Cells |
| title_full | Long-Term Remission of Primary Bone Marrow Diffuse Large B-Cell Lymphoma Treated with High-Dose Chemotherapy Rescued by In Vivo Rituximab-Purged Autologous Stem Cells |
| title_fullStr | Long-Term Remission of Primary Bone Marrow Diffuse Large B-Cell Lymphoma Treated with High-Dose Chemotherapy Rescued by In Vivo Rituximab-Purged Autologous Stem Cells |
| title_full_unstemmed | Long-Term Remission of Primary Bone Marrow Diffuse Large B-Cell Lymphoma Treated with High-Dose Chemotherapy Rescued by In Vivo Rituximab-Purged Autologous Stem Cells |
| title_short | Long-Term Remission of Primary Bone Marrow Diffuse Large B-Cell Lymphoma Treated with High-Dose Chemotherapy Rescued by In Vivo Rituximab-Purged Autologous Stem Cells |
| title_sort | long term remission of primary bone marrow diffuse large b cell lymphoma treated with high dose chemotherapy rescued by in vivo rituximab purged autologous stem cells |
| url | http://dx.doi.org/10.1155/2012/957063 |
| work_keys_str_mv | AT hiroshikazama longtermremissionofprimarybonemarrowdiffuselargebcelllymphomatreatedwithhighdosechemotherapyrescuedbyinvivorituximabpurgedautologousstemcells AT masanaoteramura longtermremissionofprimarybonemarrowdiffuselargebcelllymphomatreatedwithhighdosechemotherapyrescuedbyinvivorituximabpurgedautologousstemcells AT kentaroyoshinaga longtermremissionofprimarybonemarrowdiffuselargebcelllymphomatreatedwithhighdosechemotherapyrescuedbyinvivorituximabpurgedautologousstemcells AT akihiromasuda longtermremissionofprimarybonemarrowdiffuselargebcelllymphomatreatedwithhighdosechemotherapyrescuedbyinvivorituximabpurgedautologousstemcells AT toshikomotoji longtermremissionofprimarybonemarrowdiffuselargebcelllymphomatreatedwithhighdosechemotherapyrescuedbyinvivorituximabpurgedautologousstemcells |