Generalized bullous fixed drug eruption induced by chlordiazepoxide: a case report of a potentially lethal adverse effect
BACKGROUND: Fixed drug eruption is a type of adverse drug reaction affecting the skin, marked by recurrent rashes that appear at the same site each time a particular drug is taken. Generalized bullous fixed drug eruption (GBFDE) is a severe form of FDE characterized by vesicles or bullae and involve...
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Eco-Vector
2025-04-01
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| Series: | Consortium Psychiatricum |
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| Online Access: | https://consortium-psy.com/jour/article/viewFile/15563/pdf |
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| author | Rishabh Singh Vaibhav Kumar Sudhanshu Mariam Shafiq Markanday Sharma |
| author_facet | Rishabh Singh Vaibhav Kumar Sudhanshu Mariam Shafiq Markanday Sharma |
| author_sort | Rishabh Singh |
| collection | DOAJ |
| description | BACKGROUND: Fixed drug eruption is a type of adverse drug reaction affecting the skin, marked by recurrent rashes that appear at the same site each time a particular drug is taken. Generalized bullous fixed drug eruption (GBFDE) is a severe form of FDE characterized by vesicles or bullae and involvement of a significant portion of the body surface area. To date, no association between GBFDE and chlordiazepoxide has been reported in the literature.
CASE REPORT: The authors present the case of a 40-year-old male inpatient in the psychiatry department of a tertiary care hospital in Assam, India. The patient was admitted in an alcohol withdrawal state and was initially prescribed chlordiazepoxide at a dose of 60 mg/day. He developed GBFDE within a day of chlordiazepoxide administration. The drug was discontinued, and he was treated with oral and topical corticosteroids instead, resulting in a significant improvement.
CONCLUSION: Сhlordiazepoxide is a rare but potential trigger of GBFDE. Clinicians should closely monitor patients on chlordiazepoxide for possible signs of GBFDE. |
| format | Article |
| id | doaj-art-ce7286f20bac4f3dbaa548e0803f7c59 |
| institution | Kabale University |
| issn | 2712-7672 2713-2919 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Eco-Vector |
| record_format | Article |
| series | Consortium Psychiatricum |
| spelling | doaj-art-ce7286f20bac4f3dbaa548e0803f7c592025-08-21T10:24:59ZengEco-VectorConsortium Psychiatricum2712-76722713-29192025-04-0161303610.17816/CP15563165Generalized bullous fixed drug eruption induced by chlordiazepoxide: a case report of a potentially lethal adverse effectRishabh Singh0https://orcid.org/0000-0002-9140-6457Vaibhav Kumar Sudhanshu1Mariam Shafiq2Markanday Sharma3https://orcid.org/0000-0001-5697-5091Command Hospital (Eastern Command)Command Hospital (Eastern Command)Command Hospital (Eastern Command)Military HospitalBACKGROUND: Fixed drug eruption is a type of adverse drug reaction affecting the skin, marked by recurrent rashes that appear at the same site each time a particular drug is taken. Generalized bullous fixed drug eruption (GBFDE) is a severe form of FDE characterized by vesicles or bullae and involvement of a significant portion of the body surface area. To date, no association between GBFDE and chlordiazepoxide has been reported in the literature. CASE REPORT: The authors present the case of a 40-year-old male inpatient in the psychiatry department of a tertiary care hospital in Assam, India. The patient was admitted in an alcohol withdrawal state and was initially prescribed chlordiazepoxide at a dose of 60 mg/day. He developed GBFDE within a day of chlordiazepoxide administration. The drug was discontinued, and he was treated with oral and topical corticosteroids instead, resulting in a significant improvement. CONCLUSION: Сhlordiazepoxide is a rare but potential trigger of GBFDE. Clinicians should closely monitor patients on chlordiazepoxide for possible signs of GBFDE.https://consortium-psy.com/jour/article/viewFile/15563/pdfgeneralized bullous fixed drug eruptionchlordiazepoxidealcohol withdrawalbenzodiazepinesadverse effectcase report |
| spellingShingle | Rishabh Singh Vaibhav Kumar Sudhanshu Mariam Shafiq Markanday Sharma Generalized bullous fixed drug eruption induced by chlordiazepoxide: a case report of a potentially lethal adverse effect Consortium Psychiatricum generalized bullous fixed drug eruption chlordiazepoxide alcohol withdrawal benzodiazepines adverse effect case report |
| title | Generalized bullous fixed drug eruption induced by chlordiazepoxide: a case report of a potentially lethal adverse effect |
| title_full | Generalized bullous fixed drug eruption induced by chlordiazepoxide: a case report of a potentially lethal adverse effect |
| title_fullStr | Generalized bullous fixed drug eruption induced by chlordiazepoxide: a case report of a potentially lethal adverse effect |
| title_full_unstemmed | Generalized bullous fixed drug eruption induced by chlordiazepoxide: a case report of a potentially lethal adverse effect |
| title_short | Generalized bullous fixed drug eruption induced by chlordiazepoxide: a case report of a potentially lethal adverse effect |
| title_sort | generalized bullous fixed drug eruption induced by chlordiazepoxide a case report of a potentially lethal adverse effect |
| topic | generalized bullous fixed drug eruption chlordiazepoxide alcohol withdrawal benzodiazepines adverse effect case report |
| url | https://consortium-psy.com/jour/article/viewFile/15563/pdf |
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