Diagnostic Utility of Pentraxin 3 Expression in Septic Cardiomyopathy: Findings from a Prospective Observational Study
Na Cui,1,2,* Xiao-Wei Lv,2,* Teng-Hao Shao,2 Zhan-Biao Yu,2 Zhi Chen,2 Tao Sun,2 Tie-Min Li,2 Jin-Wen Zhang,2 Zhen-Jie Hu1 1Department of Critical Care Medicine, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050010, People’s Republic of China; 2Dep...
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Dove Medical Press
2025-05-01
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| author | Cui N Lv XW Shao TH Yu ZB Chen Z Sun T Li TM Zhang JW Hu ZJ |
| author_facet | Cui N Lv XW Shao TH Yu ZB Chen Z Sun T Li TM Zhang JW Hu ZJ |
| author_sort | Cui N |
| collection | DOAJ |
| description | Na Cui,1,2,&ast; Xiao-Wei Lv,2,&ast; Teng-Hao Shao,2 Zhan-Biao Yu,2 Zhi Chen,2 Tao Sun,2 Tie-Min Li,2 Jin-Wen Zhang,2 Zhen-Jie Hu1 1Department of Critical Care Medicine, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050010, People’s Republic of China; 2Department of Critical Care Medicine, Affiliated Hospital of Hebei University, Baoding, 071000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhen-Jie Hu, Department of Critical Care Medicine, The Fourth Affiliated Hospital of Hebei Medical University, No. 12, Jiankang Road, Shijiazhuang, 050010, People’s Republic of China, Tel +86 13933856908, Email 46400533@hebmu.edu.cnObjective: The aim of this study is to investigate the expression levels of Pentraxin 3, PTX3 in patients with septic cardiomyopathy, SCM and evaluate its diagnostic potential for predicting SCM.Methods: A prospective observational study was conducted involving 122 patients diagnosed with septic shock between February 2023 and August 2024. Demographic and clinical data, along with plasma PTX3 concentrations were recorded. Participants were categorized into two groups based on the presence of SCM. PTX3 concentrations and their dynamic changes were compared between the groups. The correlations between PTX3 concentrations and other clinical indicators were analyzed, and the influencing factors associated with SCM development were assessed. The predictive performance of PTX3 for SCM was evaluated using receiver operating characteristic, ROC curves.Results: SCM was identified in 24.6% of the participants. Plasma PTX3 concentrations at admission and on day 3 were significantly higher in the SCM group compared to the non-SCM group, p < 0.001. However, no significant differences were observed on day 7, p > 0.05. PTX3 concentrations decreased over time in both groups. Plasma PTX3 concentrations were correlated with procalcitonin, lactate, myoglobin, troponin I, the elevated levels of troponin I on day 2 compared to admission, Sequential Organ Failure Assessment score, Acute Physiology and Chronic Health Evaluation II score, and intensive care unit length of stay. Elevated plasma PTX3 concentrations were identified as an independent risk factor for SCM development. The area under the ROC curve for PTX3 in predicting SCM was 0.784, p < 0.001, with a cutoff value of 20.82 ng/mL, sensitivity of 0.767, and specificity of 0.707.Conclusion: Plasma PTX3 concentrations are markedly elevated in patients with SCM, indicating that PTX3 may serve as a reliable biomarker for the early diagnosis of SCM.Keywords: diagnosis, PTX3, sepsis, septic cardiomyopathy, septic shock |
| format | Article |
| id | doaj-art-ce724e64b6eb450c92dcd05a5bfe35d2 |
| institution | Kabale University |
| issn | 1178-7031 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Dove Medical Press |
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| series | Journal of Inflammation Research |
| spelling | doaj-art-ce724e64b6eb450c92dcd05a5bfe35d22025-08-20T03:53:11ZengDove Medical PressJournal of Inflammation Research1178-70312025-05-01Volume 18Issue 160256035102759Diagnostic Utility of Pentraxin 3 Expression in Septic Cardiomyopathy: Findings from a Prospective Observational StudyCui N0Lv XW1Shao TH2Yu ZB3Chen Z4Sun T5Li TM6Zhang JW7Hu ZJ8Department of Critical Care MedicineDepartment of Critical Care MedicineDepartment of Critical Care MedicineDepartment of Critical Care MedicineDepartment of Critical Care MedicineDepartment of Critical Care MedicineDepartment of Critical Care MedicineDepartment of Critical Care MedicineDepartment of Critical Care MedicineNa Cui,1,2,&ast; Xiao-Wei Lv,2,&ast; Teng-Hao Shao,2 Zhan-Biao Yu,2 Zhi Chen,2 Tao Sun,2 Tie-Min Li,2 Jin-Wen Zhang,2 Zhen-Jie Hu1 1Department of Critical Care Medicine, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050010, People’s Republic of China; 2Department of Critical Care Medicine, Affiliated Hospital of Hebei University, Baoding, 071000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhen-Jie Hu, Department of Critical Care Medicine, The Fourth Affiliated Hospital of Hebei Medical University, No. 12, Jiankang Road, Shijiazhuang, 050010, People’s Republic of China, Tel +86 13933856908, Email 46400533@hebmu.edu.cnObjective: The aim of this study is to investigate the expression levels of Pentraxin 3, PTX3 in patients with septic cardiomyopathy, SCM and evaluate its diagnostic potential for predicting SCM.Methods: A prospective observational study was conducted involving 122 patients diagnosed with septic shock between February 2023 and August 2024. Demographic and clinical data, along with plasma PTX3 concentrations were recorded. Participants were categorized into two groups based on the presence of SCM. PTX3 concentrations and their dynamic changes were compared between the groups. The correlations between PTX3 concentrations and other clinical indicators were analyzed, and the influencing factors associated with SCM development were assessed. The predictive performance of PTX3 for SCM was evaluated using receiver operating characteristic, ROC curves.Results: SCM was identified in 24.6% of the participants. Plasma PTX3 concentrations at admission and on day 3 were significantly higher in the SCM group compared to the non-SCM group, p < 0.001. However, no significant differences were observed on day 7, p > 0.05. PTX3 concentrations decreased over time in both groups. Plasma PTX3 concentrations were correlated with procalcitonin, lactate, myoglobin, troponin I, the elevated levels of troponin I on day 2 compared to admission, Sequential Organ Failure Assessment score, Acute Physiology and Chronic Health Evaluation II score, and intensive care unit length of stay. Elevated plasma PTX3 concentrations were identified as an independent risk factor for SCM development. The area under the ROC curve for PTX3 in predicting SCM was 0.784, p < 0.001, with a cutoff value of 20.82 ng/mL, sensitivity of 0.767, and specificity of 0.707.Conclusion: Plasma PTX3 concentrations are markedly elevated in patients with SCM, indicating that PTX3 may serve as a reliable biomarker for the early diagnosis of SCM.Keywords: diagnosis, PTX3, sepsis, septic cardiomyopathy, septic shockhttps://www.dovepress.com/diagnostic-utility-of-pentraxin-3-expression-in-septic-cardiomyopathy--peer-reviewed-fulltext-article-JIRdiagnosisPTX3sepsisseptic cardiomyopathyseptic shock |
| spellingShingle | Cui N Lv XW Shao TH Yu ZB Chen Z Sun T Li TM Zhang JW Hu ZJ Diagnostic Utility of Pentraxin 3 Expression in Septic Cardiomyopathy: Findings from a Prospective Observational Study Journal of Inflammation Research diagnosis PTX3 sepsis septic cardiomyopathy septic shock |
| title | Diagnostic Utility of Pentraxin 3 Expression in Septic Cardiomyopathy: Findings from a Prospective Observational Study |
| title_full | Diagnostic Utility of Pentraxin 3 Expression in Septic Cardiomyopathy: Findings from a Prospective Observational Study |
| title_fullStr | Diagnostic Utility of Pentraxin 3 Expression in Septic Cardiomyopathy: Findings from a Prospective Observational Study |
| title_full_unstemmed | Diagnostic Utility of Pentraxin 3 Expression in Septic Cardiomyopathy: Findings from a Prospective Observational Study |
| title_short | Diagnostic Utility of Pentraxin 3 Expression in Septic Cardiomyopathy: Findings from a Prospective Observational Study |
| title_sort | diagnostic utility of pentraxin 3 expression in septic cardiomyopathy findings from a prospective observational study |
| topic | diagnosis PTX3 sepsis septic cardiomyopathy septic shock |
| url | https://www.dovepress.com/diagnostic-utility-of-pentraxin-3-expression-in-septic-cardiomyopathy--peer-reviewed-fulltext-article-JIR |
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