Evaluation of annexin A1, carbonic anhydrase 1, and elongation factor 1-gamma levels in periodontal diseases
Abstract Background Periodontitis arises from dysbiotic subgingival microbiota and an unresolved inflammatory response. Annexin A1 (ANXA1), Carbonic Anhydrase I (CA1), and Elongation Factor 1-gamma (EF1-Ɣ) may play a role in periodontal inflammation and disease pathogenesis. This study aimed to inve...
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2025-05-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-025-06049-4 |
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| author | Bilge Cansu Uzun Saylan Büşra Yılmaz Veli Özgen Öztürk Harika Atmaca Gülnur Emingil |
| author_facet | Bilge Cansu Uzun Saylan Büşra Yılmaz Veli Özgen Öztürk Harika Atmaca Gülnur Emingil |
| author_sort | Bilge Cansu Uzun Saylan |
| collection | DOAJ |
| description | Abstract Background Periodontitis arises from dysbiotic subgingival microbiota and an unresolved inflammatory response. Annexin A1 (ANXA1), Carbonic Anhydrase I (CA1), and Elongation Factor 1-gamma (EF1-Ɣ) may play a role in periodontal inflammation and disease pathogenesis. This study aimed to investigate the levels of these molecules in gingival crevicular fluid (GCF) of individuals with different periodontal conditions. Methods GCF samples were collected from 20 patients with Stage III Grade B periodontitis, 20 with Stage III Grade C periodontitis, 19 gingivitis patients, and 21 periodontally healthy individuals. ANXA1, CA1, and EF1-Ɣ levels were measured using ELISA. Results Clinical parameters were significantly higher in periodontitis groups compared to gingivitis and healthy groups (p < 0.001). GCF EF1-Ɣ total amount differed among groups, with higher levels in gingivitis compared to periodontitis and healthy control groups (p < 0.001). Elevated levels of EF1-Ɣ were found in gingivitis compared to Stage III/B and Stage III/C periodontitis (p < 0.001). GCF ANXA1 and CA1 levels were similar across study groups (p > 0.05). Conclusion Within the limitations of this study, it might be suggested that the decreased levels of EF1-Ɣ in diseased sites of periodontitis and its elevated levels in gingivitis are associated with the pathogenesis of periodontal disease. |
| format | Article |
| id | doaj-art-ce70df84cd30422faf7c3187677f3cf3 |
| institution | Kabale University |
| issn | 1472-6831 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj-art-ce70df84cd30422faf7c3187677f3cf32025-08-20T03:52:24ZengBMCBMC Oral Health1472-68312025-05-012511910.1186/s12903-025-06049-4Evaluation of annexin A1, carbonic anhydrase 1, and elongation factor 1-gamma levels in periodontal diseasesBilge Cansu Uzun Saylan0Büşra Yılmaz1Veli Özgen Öztürk2Harika Atmaca3Gülnur Emingil4Faculty of Dentistry, Department of Periodontology, Dokuz Eylul UniversityFaculty of Dentistry, Department of Periodontology, Ege UniversityFaculty of Dentistry, Department of Periodontology, Aydın Adnan Menderes UniversityDepartment of Biology, Faculty of Engineering and Natural Sciences, Manisa Celal Bayar UniversityFaculty of Dentistry, Department of Periodontology, İstinye UniversityAbstract Background Periodontitis arises from dysbiotic subgingival microbiota and an unresolved inflammatory response. Annexin A1 (ANXA1), Carbonic Anhydrase I (CA1), and Elongation Factor 1-gamma (EF1-Ɣ) may play a role in periodontal inflammation and disease pathogenesis. This study aimed to investigate the levels of these molecules in gingival crevicular fluid (GCF) of individuals with different periodontal conditions. Methods GCF samples were collected from 20 patients with Stage III Grade B periodontitis, 20 with Stage III Grade C periodontitis, 19 gingivitis patients, and 21 periodontally healthy individuals. ANXA1, CA1, and EF1-Ɣ levels were measured using ELISA. Results Clinical parameters were significantly higher in periodontitis groups compared to gingivitis and healthy groups (p < 0.001). GCF EF1-Ɣ total amount differed among groups, with higher levels in gingivitis compared to periodontitis and healthy control groups (p < 0.001). Elevated levels of EF1-Ɣ were found in gingivitis compared to Stage III/B and Stage III/C periodontitis (p < 0.001). GCF ANXA1 and CA1 levels were similar across study groups (p > 0.05). Conclusion Within the limitations of this study, it might be suggested that the decreased levels of EF1-Ɣ in diseased sites of periodontitis and its elevated levels in gingivitis are associated with the pathogenesis of periodontal disease.https://doi.org/10.1186/s12903-025-06049-4PeriodontitisGingivitisGingival crevicular fluidAnnexin-a1Carbonic anhydrase-1Elongation factor-1 gamma |
| spellingShingle | Bilge Cansu Uzun Saylan Büşra Yılmaz Veli Özgen Öztürk Harika Atmaca Gülnur Emingil Evaluation of annexin A1, carbonic anhydrase 1, and elongation factor 1-gamma levels in periodontal diseases BMC Oral Health Periodontitis Gingivitis Gingival crevicular fluid Annexin-a1 Carbonic anhydrase-1 Elongation factor-1 gamma |
| title | Evaluation of annexin A1, carbonic anhydrase 1, and elongation factor 1-gamma levels in periodontal diseases |
| title_full | Evaluation of annexin A1, carbonic anhydrase 1, and elongation factor 1-gamma levels in periodontal diseases |
| title_fullStr | Evaluation of annexin A1, carbonic anhydrase 1, and elongation factor 1-gamma levels in periodontal diseases |
| title_full_unstemmed | Evaluation of annexin A1, carbonic anhydrase 1, and elongation factor 1-gamma levels in periodontal diseases |
| title_short | Evaluation of annexin A1, carbonic anhydrase 1, and elongation factor 1-gamma levels in periodontal diseases |
| title_sort | evaluation of annexin a1 carbonic anhydrase 1 and elongation factor 1 gamma levels in periodontal diseases |
| topic | Periodontitis Gingivitis Gingival crevicular fluid Annexin-a1 Carbonic anhydrase-1 Elongation factor-1 gamma |
| url | https://doi.org/10.1186/s12903-025-06049-4 |
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