Evaluation of annexin A1, carbonic anhydrase 1, and elongation factor 1-gamma levels in periodontal diseases

Evaluation of annexin A1, carbonic anhydrase 1, and elongation factor 1-gamma levels in periodontal diseases

Abstract Background Periodontitis arises from dysbiotic subgingival microbiota and an unresolved inflammatory response. Annexin A1 (ANXA1), Carbonic Anhydrase I (CA1), and Elongation Factor 1-gamma (EF1-Ɣ) may play a role in periodontal inflammation and disease pathogenesis. This study aimed to inve...

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Bibliographic Details
Main Authors: Bilge Cansu Uzun Saylan, Büşra Yılmaz, Veli Özgen Öztürk, Harika Atmaca, Gülnur Emingil
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Oral Health
Subjects:
Periodontitis
Gingivitis
Gingival crevicular fluid
Annexin-a1
Carbonic anhydrase-1
Elongation factor-1 gamma
Online Access:https://doi.org/10.1186/s12903-025-06049-4
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Summary:Abstract Background Periodontitis arises from dysbiotic subgingival microbiota and an unresolved inflammatory response. Annexin A1 (ANXA1), Carbonic Anhydrase I (CA1), and Elongation Factor 1-gamma (EF1-Ɣ) may play a role in periodontal inflammation and disease pathogenesis. This study aimed to investigate the levels of these molecules in gingival crevicular fluid (GCF) of individuals with different periodontal conditions. Methods GCF samples were collected from 20 patients with Stage III Grade B periodontitis, 20 with Stage III Grade C periodontitis, 19 gingivitis patients, and 21 periodontally healthy individuals. ANXA1, CA1, and EF1-Ɣ levels were measured using ELISA. Results Clinical parameters were significantly higher in periodontitis groups compared to gingivitis and healthy groups (p < 0.001). GCF EF1-Ɣ total amount differed among groups, with higher levels in gingivitis compared to periodontitis and healthy control groups (p < 0.001). Elevated levels of EF1-Ɣ were found in gingivitis compared to Stage III/B and Stage III/C periodontitis (p < 0.001). GCF ANXA1 and CA1 levels were similar across study groups (p > 0.05). Conclusion Within the limitations of this study, it might be suggested that the decreased levels of EF1-Ɣ in diseased sites of periodontitis and its elevated levels in gingivitis are associated with the pathogenesis of periodontal disease.
ISSN:1472-6831

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