Correlation between serum magnesium level and arteriosclerosis in maintenance hemodialysis patients
Objective To explore the effect of serum magnesium level on arteriosclerosis in maintenance hemodialysis（MHD） patients. Methods From January 1, 2020 to June 30, 2023, 155 MHD patients were recruited. Based upon the tertile of average serum magnesium level, they were assigned into three groups of hig...
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Editorial Department of Journal of Clinical Nephrology
2024-12-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/cn/article/doi/10.3969/j.issn.1671-2390.2024.12.006 |
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| author | Dan-yan Min Ting Shen Ting Zhang Jun-jun Zhu Miao Liu Qiu-nan Zhan Jun-li Zhao |
| author_facet | Dan-yan Min Ting Shen Ting Zhang Jun-jun Zhu Miao Liu Qiu-nan Zhan Jun-li Zhao |
| author_sort | Dan-yan Min |
| collection | DOAJ |
| description | Objective To explore the effect of serum magnesium level on arteriosclerosis in maintenance hemodialysis（MHD） patients. Methods From January 1, 2020 to June 30, 2023, 155 MHD patients were recruited. Based upon the tertile of average serum magnesium level, they were assigned into three groups of high magnesium group（blood magnesium≥1.82 mmol/L, n=50）, medium magnesium（1.61 mmol/L≤blood magnesium＜1.82 mmol/L） and low magnesium（blood magnesium ＜1.61 mmol/L, n=58）. Brachial-ankle pulse wave velocity（baPWV）, pulse pressure index（PPI）, intima-media thickness（IMT） of carotid artery and arteriosclerosis-related parameters were compared. Receiver operating characteristic（ROC） curve was plotted for examining the predictive value of magnesium ion level for arteriosclerosis in MHD patients. Results baPWV（1424.78 ± 224.51 vs 1342.00 ± 204.85、1301.24 ± 192.48）, pulse pressure index（PPI）（0.52 ± 0.13 vs 0.46 ± 0.13、0.44 ± 0.10） and IMT（1.24 ± 0.22 vs 1.08 ± 0.18、0.95 ± 0.21） were significantly higher in low magnesium group than those in medium/high magnesium group. There were statistically significant differences（P＜0.05）. Pearson’s correlation analysis indicated that serum magnesium level was significantly correlated negatively with baPWV and PPI（P＜0.05）. Binary Logistic regression analysis revealed that the influencing factors for the occurrence of arteriosclerosis were age（OR=1.072, P＜0.05）, hypertension（OR=2.764, P＜0.05）, serum phosphorus （OR=1.105, P＜0.05） and serum magnesium （OR=0.732, P＜0.05）. ROC curve analysis revealed that area under the curve（AUC） value was 0.872, optimal cut-off value 1.15 mmol/L and sensitivity 80.45% and specificity 64.32%. Conclusion As compared with moderate/high magnesium level, the related parameters of arteriosclerosis in MHD patients spike significantly with low magnesium level. And serum magnesium level has an excellent predictive value for the occurrence of arteriosclerosis. |
| format | Article |
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| issn | 1671-2390 |
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| publishDate | 2024-12-01 |
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| spelling | doaj-art-ce6e9c1743ea40ed98dadfde937749922025-08-20T02:35:32ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902024-12-0124121010101610.3969/j.issn.1671-2390.2024.12.00620240047Correlation between serum magnesium level and arteriosclerosis in maintenance hemodialysis patientsDan-yan Min0Ting Shen1Ting Zhang2Jun-jun Zhu3Miao Liu4Qiu-nan Zhan5Jun-li Zhao6Department of Nephrology, Affiliated Zhoupu Hospital, Shanghai University of Medicine & Health Sciences, Shanghai 201318, ChinaDepartment of Nephrology, Affiliated Zhoupu Hospital, Shanghai University of Medicine & Health Sciences, Shanghai 201318, ChinaDepartment of Nephrology, Affiliated Zhoupu Hospital, Shanghai University of Medicine & Health Sciences, Shanghai 201318, ChinaDepartment of Nephrology, Affiliated Zhoupu Hospital, Shanghai University of Medicine & Health Sciences, Shanghai 201318, ChinaDepartment of Nephrology, Affiliated Zhoupu Hospital, Shanghai University of Medicine & Health Sciences, Shanghai 201318, ChinaDepartment of Nephrology, Affiliated Zhoupu Hospital, Shanghai University of Medicine & Health Sciences, Shanghai 201318, ChinaDepartment of Nephrology, Affiliated Zhoupu Hospital, Shanghai University of Medicine & Health Sciences, Shanghai 201318, ChinaObjective To explore the effect of serum magnesium level on arteriosclerosis in maintenance hemodialysis（MHD） patients. Methods From January 1, 2020 to June 30, 2023, 155 MHD patients were recruited. Based upon the tertile of average serum magnesium level, they were assigned into three groups of high magnesium group（blood magnesium≥1.82 mmol/L, n=50）, medium magnesium（1.61 mmol/L≤blood magnesium＜1.82 mmol/L） and low magnesium（blood magnesium ＜1.61 mmol/L, n=58）. Brachial-ankle pulse wave velocity（baPWV）, pulse pressure index（PPI）, intima-media thickness（IMT） of carotid artery and arteriosclerosis-related parameters were compared. Receiver operating characteristic（ROC） curve was plotted for examining the predictive value of magnesium ion level for arteriosclerosis in MHD patients. Results baPWV（1424.78 ± 224.51 vs 1342.00 ± 204.85、1301.24 ± 192.48）, pulse pressure index（PPI）（0.52 ± 0.13 vs 0.46 ± 0.13、0.44 ± 0.10） and IMT（1.24 ± 0.22 vs 1.08 ± 0.18、0.95 ± 0.21） were significantly higher in low magnesium group than those in medium/high magnesium group. There were statistically significant differences（P＜0.05）. Pearson’s correlation analysis indicated that serum magnesium level was significantly correlated negatively with baPWV and PPI（P＜0.05）. Binary Logistic regression analysis revealed that the influencing factors for the occurrence of arteriosclerosis were age（OR=1.072, P＜0.05）, hypertension（OR=2.764, P＜0.05）, serum phosphorus （OR=1.105, P＜0.05） and serum magnesium （OR=0.732, P＜0.05）. ROC curve analysis revealed that area under the curve（AUC） value was 0.872, optimal cut-off value 1.15 mmol/L and sensitivity 80.45% and specificity 64.32%. Conclusion As compared with moderate/high magnesium level, the related parameters of arteriosclerosis in MHD patients spike significantly with low magnesium level. And serum magnesium level has an excellent predictive value for the occurrence of arteriosclerosis.http://www.lcszb.com/cn/article/doi/10.3969/j.issn.1671-2390.2024.12.006magnesiumhemodialysisarteriosclerosis |
| spellingShingle | Dan-yan Min Ting Shen Ting Zhang Jun-jun Zhu Miao Liu Qiu-nan Zhan Jun-li Zhao Correlation between serum magnesium level and arteriosclerosis in maintenance hemodialysis patients Linchuang shenzangbing zazhi magnesium hemodialysis arteriosclerosis |
| title | Correlation between serum magnesium level and arteriosclerosis in maintenance hemodialysis patients |
| title_full | Correlation between serum magnesium level and arteriosclerosis in maintenance hemodialysis patients |
| title_fullStr | Correlation between serum magnesium level and arteriosclerosis in maintenance hemodialysis patients |
| title_full_unstemmed | Correlation between serum magnesium level and arteriosclerosis in maintenance hemodialysis patients |
| title_short | Correlation between serum magnesium level and arteriosclerosis in maintenance hemodialysis patients |
| title_sort | correlation between serum magnesium level and arteriosclerosis in maintenance hemodialysis patients |
| topic | magnesium hemodialysis arteriosclerosis |
| url | http://www.lcszb.com/cn/article/doi/10.3969/j.issn.1671-2390.2024.12.006 |
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