Extract of Sesbania grandiflora Ameliorates Hyperglycemia in High Fat Diet-Streptozotocin Induced Experimental Diabetes Mellitus
Background. Sesbania grandiflora has been traditionally used as antidiabetic, antioxidant, antipyretic, and expectorant and in the management of various ailments. Materials and Methods. The study evaluates the antidiabetic activity of methanolic extract of Sesbania grandiflora (MESG) in type 2 diabe...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2016/4083568 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562130602164224 |
|---|---|
| author | Ghanshyam Panigrahi Chhayakanta Panda Arjun Patra |
| author_facet | Ghanshyam Panigrahi Chhayakanta Panda Arjun Patra |
| author_sort | Ghanshyam Panigrahi |
| collection | DOAJ |
| description | Background. Sesbania grandiflora has been traditionally used as antidiabetic, antioxidant, antipyretic, and expectorant and in the management of various ailments. Materials and Methods. The study evaluates the antidiabetic activity of methanolic extract of Sesbania grandiflora (MESG) in type 2 diabetic rats induced by low dose streptozotocine and high fat diet. Diabetic rats were given vehicle, MESG (200 and 400 mg/kg, p.o.), and the standard drug, metformin (10 mg/kg), for 28 days. During the experimental period, body weight, abdominal girth, food intake, fasting serum glucose, urine analyses were measured. Insulin tolerance test was carried out on 25th day of drug treatment period. Serum analyses for lipid profile and SGOT and SGPT and serums creatinine, urea, protein, SOD, and MDA were also carried out. At the end of the experiment, animals were euthanized, the liver and pancreas were immediately dissected out, and the ratio of pancreas to body weight and hepatic glycogen were calculated. Results. MESG (200 and 400 mg/kg, p.o.) induced significant reduction (P<0.05) of raised blood glucose levels in diabetic rats and also restored other parameters to normal level. Conclusion. Therefore, it is concluded that MESG has potential antihyperglycemic and antihyperlipemic activities and alleviate insulin resistance conditions. |
| format | Article |
| id | doaj-art-ce6162e2d0be4f03bf7a6687758b75fb |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-ce6162e2d0be4f03bf7a6687758b75fb2025-02-03T01:23:22ZengWileyScientifica2090-908X2016-01-01201610.1155/2016/40835684083568Extract of Sesbania grandiflora Ameliorates Hyperglycemia in High Fat Diet-Streptozotocin Induced Experimental Diabetes MellitusGhanshyam Panigrahi0Chhayakanta Panda1Arjun Patra2Department of Pharmacology, Royal College of Pharmacy and Health Sciences, Berhampur, Odisha 760002, IndiaDepartment of Pharmacology, Royal College of Pharmacy and Health Sciences, Berhampur, Odisha 760002, IndiaInstitute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh 495009, IndiaBackground. Sesbania grandiflora has been traditionally used as antidiabetic, antioxidant, antipyretic, and expectorant and in the management of various ailments. Materials and Methods. The study evaluates the antidiabetic activity of methanolic extract of Sesbania grandiflora (MESG) in type 2 diabetic rats induced by low dose streptozotocine and high fat diet. Diabetic rats were given vehicle, MESG (200 and 400 mg/kg, p.o.), and the standard drug, metformin (10 mg/kg), for 28 days. During the experimental period, body weight, abdominal girth, food intake, fasting serum glucose, urine analyses were measured. Insulin tolerance test was carried out on 25th day of drug treatment period. Serum analyses for lipid profile and SGOT and SGPT and serums creatinine, urea, protein, SOD, and MDA were also carried out. At the end of the experiment, animals were euthanized, the liver and pancreas were immediately dissected out, and the ratio of pancreas to body weight and hepatic glycogen were calculated. Results. MESG (200 and 400 mg/kg, p.o.) induced significant reduction (P<0.05) of raised blood glucose levels in diabetic rats and also restored other parameters to normal level. Conclusion. Therefore, it is concluded that MESG has potential antihyperglycemic and antihyperlipemic activities and alleviate insulin resistance conditions.http://dx.doi.org/10.1155/2016/4083568 |
| spellingShingle | Ghanshyam Panigrahi Chhayakanta Panda Arjun Patra Extract of Sesbania grandiflora Ameliorates Hyperglycemia in High Fat Diet-Streptozotocin Induced Experimental Diabetes Mellitus Scientifica |
| title | Extract of Sesbania grandiflora Ameliorates Hyperglycemia in High Fat Diet-Streptozotocin Induced Experimental Diabetes Mellitus |
| title_full | Extract of Sesbania grandiflora Ameliorates Hyperglycemia in High Fat Diet-Streptozotocin Induced Experimental Diabetes Mellitus |
| title_fullStr | Extract of Sesbania grandiflora Ameliorates Hyperglycemia in High Fat Diet-Streptozotocin Induced Experimental Diabetes Mellitus |
| title_full_unstemmed | Extract of Sesbania grandiflora Ameliorates Hyperglycemia in High Fat Diet-Streptozotocin Induced Experimental Diabetes Mellitus |
| title_short | Extract of Sesbania grandiflora Ameliorates Hyperglycemia in High Fat Diet-Streptozotocin Induced Experimental Diabetes Mellitus |
| title_sort | extract of sesbania grandiflora ameliorates hyperglycemia in high fat diet streptozotocin induced experimental diabetes mellitus |
| url | http://dx.doi.org/10.1155/2016/4083568 |
| work_keys_str_mv | AT ghanshyampanigrahi extractofsesbaniagrandifloraameliorateshyperglycemiainhighfatdietstreptozotocininducedexperimentaldiabetesmellitus AT chhayakantapanda extractofsesbaniagrandifloraameliorateshyperglycemiainhighfatdietstreptozotocininducedexperimentaldiabetesmellitus AT arjunpatra extractofsesbaniagrandifloraameliorateshyperglycemiainhighfatdietstreptozotocininducedexperimentaldiabetesmellitus |