Evaluation of the Neuroprotective Effect of Lawsonia inermis Flower Extract in Alzheimer’s Disease-induced Zebrafish Model
Objective: The study aimed to evaluate the effect of Lawsonia inermis flower extract in an Alzheimer’s disease (AD)-induced zebrafish model. Materials and Methods: A total of 60 adult fishes were segregated into five groups (n = 12) and treated with various dilutions of L. inermis extract, respectiv...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | World Journal of Traditional Chinese Medicine |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/wjtcm.wjtcm_67_24 |
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| Summary: | Objective:
The study aimed to evaluate the effect of Lawsonia inermis flower extract in an Alzheimer’s disease (AD)-induced zebrafish model.
Materials and Methods:
A total of 60 adult fishes were segregated into five groups (n = 12) and treated with various dilutions of L. inermis extract, respectively. The study was conducted in two phases. The effective dilution range was identified in Phase I (7 days), and the respective dilution was used in Phase II (14 days) for sodium valproate-induced AD. The treatment groups were screened for anxiety, motor coordination, and memory using a novel tank diving test, swim velocity, and maze test, respectively. Treated fishes from each group were investigated for histopathology examination. The results were analyzed with a one-way analysis of variance followed by a post hoc Tukey multiple comparison test using GraphPad Prism.
Results:
In Phase I, a dose-dependent reduction of degeneration was observed in the pathology of the brain with no significant changes in cognition. In Phase II, the effective dose (8 μg/day/0.5 mg fish) of L. inermis flower extract has shown a significant reduction in anxiety, degeneration, and motor dysfunction with a significant increase in memory and learning.
Conclusions:
The current investigation has shown that the L. inermis flower extract has a neuroprotective impact on AD zebrafish. |
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| ISSN: | 2311-8571 |