Stability Constants of Mixed Ligand Complexes of Nickel(II) with Adenine and Some Amino Acids
Nickel is one of the essential trace elements found in biological systems. It is mostly found in nickel-based enzymes as an essential cofactor. It forms coordination complexes with amino acids within enzymes. Nickel is also present in nucleic acids, though its function in DNA or RNA is still not cle...
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Wiley
2015-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2015/374782 |
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| author | Naciye Türkel |
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| author_sort | Naciye Türkel |
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| description | Nickel is one of the essential trace elements found in biological systems. It is mostly found in nickel-based enzymes as an essential cofactor. It forms coordination complexes with amino acids within enzymes. Nickel is also present in nucleic acids, though its function in DNA or RNA is still not clearly understood. In this study, complex formation tendencies of Ni(II) with adenine and certain L-amino acids such as aspartic acid, glutamic acid, asparagine, leucine, phenylalanine, and tryptophan were investigated in an aqueous medium. Potentiometric equilibrium measurements showed that both binary and ternary complexes of Ni(II) form with adenine and the above-mentioned L-amino acids. Ternary complexes of Ni(II)-adenine-L-amino acids are formed by stepwise mechanisms. Relative stabilities of the ternary complexes are compared with those of the corresponding binary complexes in terms of Δlog10K, log10X, and % RS values. It was shown that the most stable ternary complex is Ni(II):Ade:L-Asn while the weakest one is Ni(II):Ade:L-Phe in aqueous solution used in this research. In addition, results of this research clearly show that various binary and ternary type Ni(II) complexes are formed in different concentrations as a function of pH in aqueous solution. |
| format | Article |
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| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
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| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-ce5c980a817f497d9b7d376fe5705cbd2025-02-03T01:28:52ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2015-01-01201510.1155/2015/374782374782Stability Constants of Mixed Ligand Complexes of Nickel(II) with Adenine and Some Amino AcidsNaciye Türkel0Faculty of Arts and Sciences, Department of Chemistry, Uludağ University, 16059 Bursa, TurkeyNickel is one of the essential trace elements found in biological systems. It is mostly found in nickel-based enzymes as an essential cofactor. It forms coordination complexes with amino acids within enzymes. Nickel is also present in nucleic acids, though its function in DNA or RNA is still not clearly understood. In this study, complex formation tendencies of Ni(II) with adenine and certain L-amino acids such as aspartic acid, glutamic acid, asparagine, leucine, phenylalanine, and tryptophan were investigated in an aqueous medium. Potentiometric equilibrium measurements showed that both binary and ternary complexes of Ni(II) form with adenine and the above-mentioned L-amino acids. Ternary complexes of Ni(II)-adenine-L-amino acids are formed by stepwise mechanisms. Relative stabilities of the ternary complexes are compared with those of the corresponding binary complexes in terms of Δlog10K, log10X, and % RS values. It was shown that the most stable ternary complex is Ni(II):Ade:L-Asn while the weakest one is Ni(II):Ade:L-Phe in aqueous solution used in this research. In addition, results of this research clearly show that various binary and ternary type Ni(II) complexes are formed in different concentrations as a function of pH in aqueous solution.http://dx.doi.org/10.1155/2015/374782 |
| spellingShingle | Naciye Türkel Stability Constants of Mixed Ligand Complexes of Nickel(II) with Adenine and Some Amino Acids Bioinorganic Chemistry and Applications |
| title | Stability Constants of Mixed Ligand Complexes of Nickel(II) with Adenine and Some Amino Acids |
| title_full | Stability Constants of Mixed Ligand Complexes of Nickel(II) with Adenine and Some Amino Acids |
| title_fullStr | Stability Constants of Mixed Ligand Complexes of Nickel(II) with Adenine and Some Amino Acids |
| title_full_unstemmed | Stability Constants of Mixed Ligand Complexes of Nickel(II) with Adenine and Some Amino Acids |
| title_short | Stability Constants of Mixed Ligand Complexes of Nickel(II) with Adenine and Some Amino Acids |
| title_sort | stability constants of mixed ligand complexes of nickel ii with adenine and some amino acids |
| url | http://dx.doi.org/10.1155/2015/374782 |
| work_keys_str_mv | AT naciyeturkel stabilityconstantsofmixedligandcomplexesofnickeliiwithadenineandsomeaminoacids |