Mechanosensitive lncRNA H19 promotes chondrocyte autophagy, but not pyroptosis, by targeting miR-148a in post-traumatic osteoarthritis

Mechanosensitive lncRNA H19 promotes chondrocyte autophagy, but not pyroptosis, by targeting miR-148a in post-traumatic osteoarthritis

Objective: Investigating whether mechanosensitive lncRNA H19 can directly target miR-148a to alleviate cartilage damage in post-traumatic osteoarthritis (PTOA). Methods: Thirty-two female rats were randomly divided into four groups: Sham-operated group (Sham group, n = 8), treadmill running group (R...

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Bibliographic Details
Main Authors: Xuchang Zhou, Hong Cao, Tao Liao, Weizhong Hua, Ruobing Zhao, Dongxue Wang, Huili Deng, Yajing Yang, ShengYao Liu, Guoxin Ni
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-02-01
Series:Non-coding RNA Research
Subjects:
lncRNA H19
miR-148a
Osteoarthritis
Mechanical load
Exercise
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S2468054024001252
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