Neurobiological Changes Associated with Excess Weight: A Narrative Review
Brain and neuronal changes related to excessive weight and obesity is critical due to address, given the rising global prevalence of obesity and its significant impact on neurological health. Obesity is associated with significant neuronal changes that can have profound effects on brain structure an...
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JCDR Research and Publications Private Limited
2025-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/20542/76172_CE[Ra1]_F(SHU)_QC(SD_SHU)_PF1(RI_SL)_redo_PFA(IS)_PB(RI_IS)_PN(IS).pdf |
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| author | B Sharmila Sovan Bagchi Mohd Imran Tamalika Chakraborty K Pushpalatha |
| author_facet | B Sharmila Sovan Bagchi Mohd Imran Tamalika Chakraborty K Pushpalatha |
| author_sort | B Sharmila |
| collection | DOAJ |
| description | Brain and neuronal changes related to excessive weight and obesity is critical due to address, given the rising global prevalence of obesity and its significant impact on neurological health. Obesity is associated with significant neuronal changes that can have profound effects on brain structure and function. These neuronal changes highlight the complex interplay between obesity and brain function, emphasising the importance of addressing both physical and neurological aspects of obesity in treatment and prevention strategies. Early reviews have often overlooked the intricate relationship between obesity and brain function, focusing more on peripheral effects, such as cardiovascular and metabolic complications, while neglecting the specific effects on brain structure and function. The present review explores the research question of how does excess weight contribute to specific structural and functional changes in brain regions involved in cognitive control, reward processing and memory and what are the implications of these changes for clinical outcomes and obesity management. It focuses on the clinical implications of neural changes in the context of obesity management. The analysis provides a comprehensive understanding of the underlying mechanisms driving these brain modifications and their potential impacts on clinical outcomes. |
| format | Article |
| id | doaj-art-ce5695aaa92a4db88ae45fd62ebf57fb |
| institution | Kabale University |
| issn | 2249-782X 0973-709X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj-art-ce5695aaa92a4db88ae45fd62ebf57fb2025-01-27T12:13:57ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2025-01-011901071210.7860/JCDR/2025/76172.20542Neurobiological Changes Associated with Excess Weight: A Narrative ReviewB Sharmila0Sovan Bagchi1Mohd Imran2https://orcid.org/0000-0002-6064-1040Tamalika Chakraborty3K Pushpalatha4Assistant Professor, College of Physiotherapy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India.Professor, Department of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman, United Arab Emirates.Associate Professor, Department of Pharmaceutical Chemistry, College of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia; Center for Health Research, Northern Border University, Arar, Saudi Arabia.Assistant Professor, Guru Nanak Institute of Pharmaceutical Science and Technology, Sodepur, Panihati, Kolkata, West Bengal, India.Professor, Department of Anatomy, JSS Medical College, JSS Academy of Higher Education and Research, Sri Shivarathreeshwara Nagara, Mysuru, Karnataka, India.Brain and neuronal changes related to excessive weight and obesity is critical due to address, given the rising global prevalence of obesity and its significant impact on neurological health. Obesity is associated with significant neuronal changes that can have profound effects on brain structure and function. These neuronal changes highlight the complex interplay between obesity and brain function, emphasising the importance of addressing both physical and neurological aspects of obesity in treatment and prevention strategies. Early reviews have often overlooked the intricate relationship between obesity and brain function, focusing more on peripheral effects, such as cardiovascular and metabolic complications, while neglecting the specific effects on brain structure and function. The present review explores the research question of how does excess weight contribute to specific structural and functional changes in brain regions involved in cognitive control, reward processing and memory and what are the implications of these changes for clinical outcomes and obesity management. It focuses on the clinical implications of neural changes in the context of obesity management. The analysis provides a comprehensive understanding of the underlying mechanisms driving these brain modifications and their potential impacts on clinical outcomes.https://www.jcdr.net/articles/PDF/20542/76172_CE[Ra1]_F(SHU)_QC(SD_SHU)_PF1(RI_SL)_redo_PFA(IS)_PB(RI_IS)_PN(IS).pdfbrain structuredopamine signallinginflammationneurological healthneuronal changesobesity |
| spellingShingle | B Sharmila Sovan Bagchi Mohd Imran Tamalika Chakraborty K Pushpalatha Neurobiological Changes Associated with Excess Weight: A Narrative Review Journal of Clinical and Diagnostic Research brain structure dopamine signalling inflammation neurological health neuronal changes obesity |
| title | Neurobiological Changes Associated with Excess Weight: A Narrative Review |
| title_full | Neurobiological Changes Associated with Excess Weight: A Narrative Review |
| title_fullStr | Neurobiological Changes Associated with Excess Weight: A Narrative Review |
| title_full_unstemmed | Neurobiological Changes Associated with Excess Weight: A Narrative Review |
| title_short | Neurobiological Changes Associated with Excess Weight: A Narrative Review |
| title_sort | neurobiological changes associated with excess weight a narrative review |
| topic | brain structure dopamine signalling inflammation neurological health neuronal changes obesity |
| url | https://www.jcdr.net/articles/PDF/20542/76172_CE[Ra1]_F(SHU)_QC(SD_SHU)_PF1(RI_SL)_redo_PFA(IS)_PB(RI_IS)_PN(IS).pdf |
| work_keys_str_mv | AT bsharmila neurobiologicalchangesassociatedwithexcessweightanarrativereview AT sovanbagchi neurobiologicalchangesassociatedwithexcessweightanarrativereview AT mohdimran neurobiologicalchangesassociatedwithexcessweightanarrativereview AT tamalikachakraborty neurobiologicalchangesassociatedwithexcessweightanarrativereview AT kpushpalatha neurobiologicalchangesassociatedwithexcessweightanarrativereview |