Protective Action of Neurotrophic Factors and Estrogen against Oxidative Stress-Mediated Neurodegeneration
Oxidative stress is involved in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. Low levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are important for maintenance of neuronal functio...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2011/405194 |
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| _version_ | 1849470529987149824 |
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| author | Tadahiro Numakawa Tomoya Matsumoto Yumiko Numakawa Misty Richards Shigeto Yamawaki Hiroshi Kunugi |
| author_facet | Tadahiro Numakawa Tomoya Matsumoto Yumiko Numakawa Misty Richards Shigeto Yamawaki Hiroshi Kunugi |
| author_sort | Tadahiro Numakawa |
| collection | DOAJ |
| description | Oxidative stress is involved in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. Low levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are important for maintenance of neuronal function, though elevated levels lead to neuronal cell death. A complex series of events including excitotoxicity, Ca2+ overload, and mitochondrial dysfunction contributes to oxidative stress-mediated neurodegeneration. As expected, many antioxidants like phytochemicals and vitamins are known to reduce oxidative toxicity. Additionally, growing evidence indicates that neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and estrogens significantly prevent neuronal damage caused by oxidative stress. Here, we review and discuss recent studies addressing the protective mechanisms of neurotrophic factors and estrogen within this system. |
| format | Article |
| id | doaj-art-ce501c4949aa4e39a233c6dcdceded0b |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-ce501c4949aa4e39a233c6dcdceded0b2025-08-20T03:25:08ZengWileyJournal of Toxicology1687-81911687-82052011-01-01201110.1155/2011/405194405194Protective Action of Neurotrophic Factors and Estrogen against Oxidative Stress-Mediated NeurodegenerationTadahiro Numakawa0Tomoya Matsumoto1Yumiko Numakawa2Misty Richards3Shigeto Yamawaki4Hiroshi Kunugi5Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187-8502, JapanCore Research for Evolutional Science and Technology Program (CREST), Japan Science and Technology Agency (JST), Saitama 332-0012, JapanPeptide-prima Co., Ltd., 1-25-81, Nuyamazu, Kumamoto 861-2102, JapanDepartment of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187-8502, JapanCore Research for Evolutional Science and Technology Program (CREST), Japan Science and Technology Agency (JST), Saitama 332-0012, JapanDepartment of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187-8502, JapanOxidative stress is involved in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. Low levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are important for maintenance of neuronal function, though elevated levels lead to neuronal cell death. A complex series of events including excitotoxicity, Ca2+ overload, and mitochondrial dysfunction contributes to oxidative stress-mediated neurodegeneration. As expected, many antioxidants like phytochemicals and vitamins are known to reduce oxidative toxicity. Additionally, growing evidence indicates that neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and estrogens significantly prevent neuronal damage caused by oxidative stress. Here, we review and discuss recent studies addressing the protective mechanisms of neurotrophic factors and estrogen within this system.http://dx.doi.org/10.1155/2011/405194 |
| spellingShingle | Tadahiro Numakawa Tomoya Matsumoto Yumiko Numakawa Misty Richards Shigeto Yamawaki Hiroshi Kunugi Protective Action of Neurotrophic Factors and Estrogen against Oxidative Stress-Mediated Neurodegeneration Journal of Toxicology |
| title | Protective Action of Neurotrophic Factors and Estrogen against Oxidative Stress-Mediated Neurodegeneration |
| title_full | Protective Action of Neurotrophic Factors and Estrogen against Oxidative Stress-Mediated Neurodegeneration |
| title_fullStr | Protective Action of Neurotrophic Factors and Estrogen against Oxidative Stress-Mediated Neurodegeneration |
| title_full_unstemmed | Protective Action of Neurotrophic Factors and Estrogen against Oxidative Stress-Mediated Neurodegeneration |
| title_short | Protective Action of Neurotrophic Factors and Estrogen against Oxidative Stress-Mediated Neurodegeneration |
| title_sort | protective action of neurotrophic factors and estrogen against oxidative stress mediated neurodegeneration |
| url | http://dx.doi.org/10.1155/2011/405194 |
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