Integration of circulating tumor DNA in biliary tract cancer: the emerging landscape
Precision medicine has emerged as a cornerstone in cancer treatment revolutionizing our approach across malignancies. Molecular profiling of biliary tract cancers (BTCs) has changed the treatment landscape positively by prolonging survival in an aggressively fatal malignancy in its advanced stages....
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| Format: | Article |
| Language: | English |
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Taylor & Francis
2024-12-01
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| Series: | Hepatic Oncology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20450923.2024.2403334 |
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| author | Joy A Awosika Cecilia Monge Tim F Greten |
| author_facet | Joy A Awosika Cecilia Monge Tim F Greten |
| author_sort | Joy A Awosika |
| collection | DOAJ |
| description | Precision medicine has emerged as a cornerstone in cancer treatment revolutionizing our approach across malignancies. Molecular profiling of biliary tract cancers (BTCs) has changed the treatment landscape positively by prolonging survival in an aggressively fatal malignancy in its advanced stages. The acquisition of tissue tumor DNA for genomic analysis in BTC is often anatomically challenging, limited by quantity and quality. In response, ctDNA has emerged as a noninvasive means of molecular profiling. The utility of both plasma and bile ctDNA has been explored in several studies demonstrating the high mutation detection rates and the ability to isolate targetable mutations when present. In addition, the concordance between plasma and tissue DNA provides validity in utilizing ctDNA results to infer treatment decisions. Analysis of ctDNA in BTC has also provided prognostic information and facilitated evaluation of clonal evolution with ease of serial measurements. Insight into novel mechanisms of resistance to targeted therapies are being uncovered in ctDNA. As research endeavors continue to deepen our understanding in the field particularly in the space of ctDNA surveillance after curative intent, the tremendous progress made so far has enabled integration of ctDNA into the clinical practice of BTCs. |
| format | Article |
| id | doaj-art-ce4e29d5d5194d68bc221087718359e8 |
| institution | Kabale University |
| issn | 2045-0923 2045-0931 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis |
| record_format | Article |
| series | Hepatic Oncology |
| spelling | doaj-art-ce4e29d5d5194d68bc221087718359e82025-01-30T06:49:32ZengTaylor & FrancisHepatic Oncology2045-09232045-09312024-12-0111110.1080/20450923.2024.2403334Integration of circulating tumor DNA in biliary tract cancer: the emerging landscapeJoy A Awosika0Cecilia Monge1Tim F Greten2Gastrointestinal Malignancies Section, Thoracic & GI Malignancies Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD 20892, USAGastrointestinal Malignancies Section, Thoracic & GI Malignancies Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD 20892, USAGastrointestinal Malignancies Section, Thoracic & GI Malignancies Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD 20892, USAPrecision medicine has emerged as a cornerstone in cancer treatment revolutionizing our approach across malignancies. Molecular profiling of biliary tract cancers (BTCs) has changed the treatment landscape positively by prolonging survival in an aggressively fatal malignancy in its advanced stages. The acquisition of tissue tumor DNA for genomic analysis in BTC is often anatomically challenging, limited by quantity and quality. In response, ctDNA has emerged as a noninvasive means of molecular profiling. The utility of both plasma and bile ctDNA has been explored in several studies demonstrating the high mutation detection rates and the ability to isolate targetable mutations when present. In addition, the concordance between plasma and tissue DNA provides validity in utilizing ctDNA results to infer treatment decisions. Analysis of ctDNA in BTC has also provided prognostic information and facilitated evaluation of clonal evolution with ease of serial measurements. Insight into novel mechanisms of resistance to targeted therapies are being uncovered in ctDNA. As research endeavors continue to deepen our understanding in the field particularly in the space of ctDNA surveillance after curative intent, the tremendous progress made so far has enabled integration of ctDNA into the clinical practice of BTCs.https://www.tandfonline.com/doi/10.1080/20450923.2024.2403334biliary tract cancercell free DNAcholangiocarcinomacirculating tumor DNAliquid biopsyprecision medicine |
| spellingShingle | Joy A Awosika Cecilia Monge Tim F Greten Integration of circulating tumor DNA in biliary tract cancer: the emerging landscape Hepatic Oncology biliary tract cancer cell free DNA cholangiocarcinoma circulating tumor DNA liquid biopsy precision medicine |
| title | Integration of circulating tumor DNA in biliary tract cancer: the emerging landscape |
| title_full | Integration of circulating tumor DNA in biliary tract cancer: the emerging landscape |
| title_fullStr | Integration of circulating tumor DNA in biliary tract cancer: the emerging landscape |
| title_full_unstemmed | Integration of circulating tumor DNA in biliary tract cancer: the emerging landscape |
| title_short | Integration of circulating tumor DNA in biliary tract cancer: the emerging landscape |
| title_sort | integration of circulating tumor dna in biliary tract cancer the emerging landscape |
| topic | biliary tract cancer cell free DNA cholangiocarcinoma circulating tumor DNA liquid biopsy precision medicine |
| url | https://www.tandfonline.com/doi/10.1080/20450923.2024.2403334 |
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