Comparative Antifungal Activity of Cilofungin (LY121019) against Candida Species, Including Evaluation of Susceptibility Testing Method
The in vitro activity of cilofungin against 100 Candida species was compared with 5-flucytosine. amphotericin B and ketoconazole by two laboratories independently and in a blinded fashion using a macrotitre dilution broth method in saam-f medium. Cilofungin showed good in vitro activity against Cand...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1992-01-01
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| Series: | Canadian Journal of Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/1992/260839 |
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| _version_ | 1832545544323465216 |
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| author | Abdul H Chagla John H Hii Daryl J Hoban Andrew E Simor Santiago Ferro Evelyn Witwicki Ruby Poon Donald E Low |
| author_facet | Abdul H Chagla John H Hii Daryl J Hoban Andrew E Simor Santiago Ferro Evelyn Witwicki Ruby Poon Donald E Low |
| author_sort | Abdul H Chagla |
| collection | DOAJ |
| description | The in vitro activity of cilofungin against 100 Candida species was compared with 5-flucytosine. amphotericin B and ketoconazole by two laboratories independently and in a blinded fashion using a macrotitre dilution broth method in saam-f medium. Cilofungin showed good in vitro activity against Candida albicans. Candida tropicalis and Candida glabrata (90% minimal inhibitory concentration [MIC] 3.2 μg/mL) but was inactive against other Candida species. When testing the susceptibility of cilofungin, 5-flucytosine and amphotericin B at the two centres, approximately 90% of the Candida strains had MICs differing by fourfold or less. However, when testing susceptibility of ketoconazole, only 51% of the Candida strains had MIC differences fourfold or less. MIC susceptibility testing with cilofungin, 5-flucytosine and amphotericin B in saam-f medium is reproducible. |
| format | Article |
| id | doaj-art-ce48fea98d424b09a3998eb6d30460af |
| institution | Kabale University |
| issn | 1180-2332 |
| language | English |
| publishDate | 1992-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases |
| spelling | doaj-art-ce48fea98d424b09a3998eb6d30460af2025-02-03T07:25:36ZengWileyCanadian Journal of Infectious Diseases1180-23321992-01-013523123410.1155/1992/260839Comparative Antifungal Activity of Cilofungin (LY121019) against Candida Species, Including Evaluation of Susceptibility Testing MethodAbdul H Chagla0John H Hii1Daryl J Hoban2Andrew E Simor3Santiago Ferro4Evelyn Witwicki5Ruby Poon6Donald E Low7Departments of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, CanadaDepartments of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, CanadaDepartments of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, CanadaDepartments of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, CanadaDepartments of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, CanadaDepartments of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, CanadaDepartments of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, CanadaDepartments of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, CanadaThe in vitro activity of cilofungin against 100 Candida species was compared with 5-flucytosine. amphotericin B and ketoconazole by two laboratories independently and in a blinded fashion using a macrotitre dilution broth method in saam-f medium. Cilofungin showed good in vitro activity against Candida albicans. Candida tropicalis and Candida glabrata (90% minimal inhibitory concentration [MIC] 3.2 μg/mL) but was inactive against other Candida species. When testing the susceptibility of cilofungin, 5-flucytosine and amphotericin B at the two centres, approximately 90% of the Candida strains had MICs differing by fourfold or less. However, when testing susceptibility of ketoconazole, only 51% of the Candida strains had MIC differences fourfold or less. MIC susceptibility testing with cilofungin, 5-flucytosine and amphotericin B in saam-f medium is reproducible.http://dx.doi.org/10.1155/1992/260839 |
| spellingShingle | Abdul H Chagla John H Hii Daryl J Hoban Andrew E Simor Santiago Ferro Evelyn Witwicki Ruby Poon Donald E Low Comparative Antifungal Activity of Cilofungin (LY121019) against Candida Species, Including Evaluation of Susceptibility Testing Method Canadian Journal of Infectious Diseases |
| title | Comparative Antifungal Activity of Cilofungin (LY121019) against Candida Species, Including Evaluation of Susceptibility Testing Method |
| title_full | Comparative Antifungal Activity of Cilofungin (LY121019) against Candida Species, Including Evaluation of Susceptibility Testing Method |
| title_fullStr | Comparative Antifungal Activity of Cilofungin (LY121019) against Candida Species, Including Evaluation of Susceptibility Testing Method |
| title_full_unstemmed | Comparative Antifungal Activity of Cilofungin (LY121019) against Candida Species, Including Evaluation of Susceptibility Testing Method |
| title_short | Comparative Antifungal Activity of Cilofungin (LY121019) against Candida Species, Including Evaluation of Susceptibility Testing Method |
| title_sort | comparative antifungal activity of cilofungin ly121019 against candida species including evaluation of susceptibility testing method |
| url | http://dx.doi.org/10.1155/1992/260839 |
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