Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and intraoperative radiation therapy in the management of gastric cancer: a 10-year single center experience
Abstract Background The rationale behind the use of HIPEC involves targeted elimination of microscopic peritoneal metastasis, a common route for GCa dissemination, thereby improving the overall survival and reducing recurrences. Moreover, the reasoning behind the use of IORT is enhanced loco-regiona...
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BMC
2025-02-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-025-03678-5 |
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| author | Marwan M. Alaswad Tarek Z. Arabi Asma S. Alshahrani Belal N. Sabbah Heba W. Jaamour Abdullah A. AlOtry Tariq W. Saleh Ziad H. Alhosainy Fadwa H. Elkordy Aya I. Elnegali Mohamed H. Tlayjeh Firas E. Kseibi Ayman Z. Azzam Tarek M. Amin |
| author_facet | Marwan M. Alaswad Tarek Z. Arabi Asma S. Alshahrani Belal N. Sabbah Heba W. Jaamour Abdullah A. AlOtry Tariq W. Saleh Ziad H. Alhosainy Fadwa H. Elkordy Aya I. Elnegali Mohamed H. Tlayjeh Firas E. Kseibi Ayman Z. Azzam Tarek M. Amin |
| author_sort | Marwan M. Alaswad |
| collection | DOAJ |
| description | Abstract Background The rationale behind the use of HIPEC involves targeted elimination of microscopic peritoneal metastasis, a common route for GCa dissemination, thereby improving the overall survival and reducing recurrences. Moreover, the reasoning behind the use of IORT is enhanced loco-regional control and, therefore, reducing recurrence rates. Methods From February 2013 to June 2023, all GCa patients who underwent HIPEC plus IORT during surgery were included in this study. Median overall survival (OS) and disease-free (DFS) survival were used to evaluate the efficacy of this treatment strategy amongst GCa patients, along with the rate of occurrence and severity of post-operative complications associated with this treatment strategy. Results The median OS and DFS were 63 and 87 months, respectively. More than one-third of the patients in our cohort did not develop any post-operative complications. In patients who developed post-operative complications, the median number of post-operative complications was 1 (IQR 1–2). Most encountered complications were Clavien-Dindo (CD) grade II complications (33.33%) and no in-hospital mortality was observed. Conclusions This complex, multimodal treatment strategy results in a significantly prolonged OS and DFS when compared to other treatment strategies for gastric cancer patients, with no added morbidity or mortality. |
| format | Article |
| id | doaj-art-ce454fce06704ad28186f836bc9ea98a |
| institution | OA Journals |
| issn | 1477-7819 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj-art-ce454fce06704ad28186f836bc9ea98a2025-08-20T02:15:16ZengBMCWorld Journal of Surgical Oncology1477-78192025-02-0123111410.1186/s12957-025-03678-5Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and intraoperative radiation therapy in the management of gastric cancer: a 10-year single center experienceMarwan M. Alaswad0Tarek Z. Arabi1Asma S. Alshahrani2Belal N. Sabbah3Heba W. Jaamour4Abdullah A. AlOtry5Tariq W. Saleh6Ziad H. Alhosainy7Fadwa H. Elkordy8Aya I. Elnegali9Mohamed H. Tlayjeh10Firas E. Kseibi11Ayman Z. Azzam12Tarek M. Amin13College of Medicine, Alfaisal UniversityCollege of Medicine, Alfaisal UniversityDepartment of Population Health, King Abdullah International Medical Research CenterCollege of Medicine, Alfaisal UniversityCollege of Medicine, Alfaisal UniversityCollege of Medicine, Alfaisal UniversityCollege of Medicine, Alfaisal UniversityCollege of Medicine, Alfaisal UniversityCollege of Medicine, Alfaisal UniversityCollege of Medicine, Alfaisal UniversityCollege of Medicine, Alfaisal UniversityCollege of Medicine, Alfaisal UniversityDepartment of Surgical Oncology, King Faisal Specialist Hospital and Research CenterDepartment of Surgical Oncology, King Faisal Specialist Hospital and Research CenterAbstract Background The rationale behind the use of HIPEC involves targeted elimination of microscopic peritoneal metastasis, a common route for GCa dissemination, thereby improving the overall survival and reducing recurrences. Moreover, the reasoning behind the use of IORT is enhanced loco-regional control and, therefore, reducing recurrence rates. Methods From February 2013 to June 2023, all GCa patients who underwent HIPEC plus IORT during surgery were included in this study. Median overall survival (OS) and disease-free (DFS) survival were used to evaluate the efficacy of this treatment strategy amongst GCa patients, along with the rate of occurrence and severity of post-operative complications associated with this treatment strategy. Results The median OS and DFS were 63 and 87 months, respectively. More than one-third of the patients in our cohort did not develop any post-operative complications. In patients who developed post-operative complications, the median number of post-operative complications was 1 (IQR 1–2). Most encountered complications were Clavien-Dindo (CD) grade II complications (33.33%) and no in-hospital mortality was observed. Conclusions This complex, multimodal treatment strategy results in a significantly prolonged OS and DFS when compared to other treatment strategies for gastric cancer patients, with no added morbidity or mortality.https://doi.org/10.1186/s12957-025-03678-5Gastric cancerHyperthermic intraperitoneal chemotherapyIntraoperative radiation therapyPeritoneal carcinomatosisOverall survivalDisease free survival |
| spellingShingle | Marwan M. Alaswad Tarek Z. Arabi Asma S. Alshahrani Belal N. Sabbah Heba W. Jaamour Abdullah A. AlOtry Tariq W. Saleh Ziad H. Alhosainy Fadwa H. Elkordy Aya I. Elnegali Mohamed H. Tlayjeh Firas E. Kseibi Ayman Z. Azzam Tarek M. Amin Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and intraoperative radiation therapy in the management of gastric cancer: a 10-year single center experience World Journal of Surgical Oncology Gastric cancer Hyperthermic intraperitoneal chemotherapy Intraoperative radiation therapy Peritoneal carcinomatosis Overall survival Disease free survival |
| title | Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and intraoperative radiation therapy in the management of gastric cancer: a 10-year single center experience |
| title_full | Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and intraoperative radiation therapy in the management of gastric cancer: a 10-year single center experience |
| title_fullStr | Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and intraoperative radiation therapy in the management of gastric cancer: a 10-year single center experience |
| title_full_unstemmed | Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and intraoperative radiation therapy in the management of gastric cancer: a 10-year single center experience |
| title_short | Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and intraoperative radiation therapy in the management of gastric cancer: a 10-year single center experience |
| title_sort | cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and intraoperative radiation therapy in the management of gastric cancer a 10 year single center experience |
| topic | Gastric cancer Hyperthermic intraperitoneal chemotherapy Intraoperative radiation therapy Peritoneal carcinomatosis Overall survival Disease free survival |
| url | https://doi.org/10.1186/s12957-025-03678-5 |
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