TLR4 deficiency does not alter glaucomatous progression in a mouse model of chronic glaucoma

Abstract Glaucoma is a leading cause of irreversible blindness worldwide. Toll-like receptor 4 (TLR4) is a pattern-recognition transmembrane receptor that induces neuroinflammatory processes in response to injury. Tlr4 is highly expressed in ocular tissues and is known to modulate inflammatory proce...

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Bibliographic Details
Main Authors: Chi Zhang, Marina Simón, Jeffrey M. Harder, Haeyn Lim, Christa Montgomery, Qing Wang, Simon W.M. John
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-025-00638-7
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