Soluble immune checkpoint landscape in sickle cell disease links systemic inflammation, autoimmunity, and pain

Soluble immune checkpoint landscape in sickle cell disease links systemic inflammation, autoimmunity, and pain

BackgroundSickle cell disease (SCD) is a chronic condition characterized by inflammation, immune dysregulation, and debilitating pain.AimThis study investigates soluble immune checkpoints (sICPs) and their associations with inflammatory mediators, immune cell profiles, autoantibodies, and clinical o...

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Bibliographic Details
Main Authors:	Wei Li, Andrew Q. Pucka, Lina Houran, Xiaoqing Huang, Candice Debats, Brandon A. Reyes, Andrew R. W. O’Brien, Qigui Yu, Ying Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Hematology
Subjects:	sickle cell disease soluble immune checkpoints inflammation autoantibodies steady-state condition vaso-occlusive crisis
Online Access:	https://www.frontiersin.org/articles/10.3389/frhem.2025.1580009/full
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