Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems
Abstract This article reports on the mechanical strength analysis and flow characteristics of square tip and circular tip microneedles by employing highly potent drugs that are given in extremely little quantity (microlitres) using MEMS technology, which proves to be a significant component of micro...
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| Format: | Article |
| Language: | English |
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Wiley
2021-07-01
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| Series: | IET Nanobiotechnology |
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| Online Access: | https://doi.org/10.1049/nbt2.12013 |
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| author | Srinivasa R. Karumuri Hamza Mohammed Koushik Guha Ashok K. Puli Ameen Einsanwi Girija S. Kondavitee |
| author_facet | Srinivasa R. Karumuri Hamza Mohammed Koushik Guha Ashok K. Puli Ameen Einsanwi Girija S. Kondavitee |
| author_sort | Srinivasa R. Karumuri |
| collection | DOAJ |
| description | Abstract This article reports on the mechanical strength analysis and flow characteristics of square tip and circular tip microneedles by employing highly potent drugs that are given in extremely little quantity (microlitres) using MEMS technology, which proves to be a significant component of micropump in the application of Bio‐MEMS. These microneedles are well suitable for a MEMS‐based micropump in the drug delivery systems. It is an essential part of the micropump through which the drug is released into the patient’s body. The proposed microneedles can withstand a stress of 23 MPa and 20 KPa. An extensive investigation on selection of material for the microneedle is carried out to meet the requirements of the biocompatibility and high yield, as well as tensile strength. As mighty drugs such as vasopressin, atropine and digoxin are administered in large quantities, the microneedle is designed so as to deliver 800 µl of drug, with each microneedle delivering 90 µl. in a 3 3 array. 3 × 3 array releasing 90 µl. |
| format | Article |
| id | doaj-art-ce3399290f8041e09c4211b73fb51acc |
| institution | Kabale University |
| issn | 1751-8741 1751-875X |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | IET Nanobiotechnology |
| spelling | doaj-art-ce3399290f8041e09c4211b73fb51acc2025-02-03T06:47:26ZengWileyIET Nanobiotechnology1751-87411751-875X2021-07-0115548449110.1049/nbt2.12013Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systemsSrinivasa R. Karumuri0Hamza Mohammed1Koushik Guha2Ashok K. Puli3Ameen Einsanwi4Girija S. Kondavitee5MEMS Research Center Department of Electronics Communication Engineering Koneru Lakshmaiah Education Foundation (Deemed to be University) Guntur Andhra Pradesh IndiaMEMS Research Center Department of Electronics Communication Engineering Koneru Lakshmaiah Education Foundation (Deemed to be University) Guntur Andhra Pradesh IndiaNational MEMS Design Center Department of Electronics Communication Engineering National Institute of Technology Silchar Assam IndiaMEMS Research Center Department of Electronics Communication Engineering Koneru Lakshmaiah Education Foundation (Deemed to be University) Guntur Andhra Pradesh IndiaMechanical Engineering American University of Iraq Sulaimani IraqMEMS Research Center Department of Electronics Communication Engineering Koneru Lakshmaiah Education Foundation (Deemed to be University) Guntur Andhra Pradesh IndiaAbstract This article reports on the mechanical strength analysis and flow characteristics of square tip and circular tip microneedles by employing highly potent drugs that are given in extremely little quantity (microlitres) using MEMS technology, which proves to be a significant component of micropump in the application of Bio‐MEMS. These microneedles are well suitable for a MEMS‐based micropump in the drug delivery systems. It is an essential part of the micropump through which the drug is released into the patient’s body. The proposed microneedles can withstand a stress of 23 MPa and 20 KPa. An extensive investigation on selection of material for the microneedle is carried out to meet the requirements of the biocompatibility and high yield, as well as tensile strength. As mighty drugs such as vasopressin, atropine and digoxin are administered in large quantities, the microneedle is designed so as to deliver 800 µl of drug, with each microneedle delivering 90 µl. in a 3 3 array. 3 × 3 array releasing 90 µl.https://doi.org/10.1049/nbt2.12013biomedical materialsbioMEMSdrug delivery systemsdrugsmechanical strengthmicrofluidics |
| spellingShingle | Srinivasa R. Karumuri Hamza Mohammed Koushik Guha Ashok K. Puli Ameen Einsanwi Girija S. Kondavitee Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems IET Nanobiotechnology biomedical materials bioMEMS drug delivery systems drugs mechanical strength microfluidics |
| title | Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems |
| title_full | Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems |
| title_fullStr | Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems |
| title_full_unstemmed | Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems |
| title_short | Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems |
| title_sort | design simulation and analysis of micro electro mechanical system microneedle for micropump in drug delivery systems |
| topic | biomedical materials bioMEMS drug delivery systems drugs mechanical strength microfluidics |
| url | https://doi.org/10.1049/nbt2.12013 |
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