Safety and efficacy of a feed additive consisting of l‐lysine sulfate produced with Corynebacterium glutamicum CGMCC 23982 for all animal species (Eppen Europa SAS)
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐lysine sulfate produced by fermentation with a non‐genetically modified strain of Corynebacterium glutamicum (CGMCC...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-04-01
|
| Series: | EFSA Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.2903/j.efsa.2025.9346 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849416101536989184 |
|---|---|
| author | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Roberto Edoardo Villa Giovanna Azimonti Eleftherios Bonos Henrik Christensen Mojca Durjava Birgit Dusemund Ronette Gehring Boet Glandorf Maryline Kouba Marta López‐Alonso Francesca Marcon Carlo Nebbia Alena Pechová Miguel Prieto‐Maradona Ilen Röhe Katerina Theodoridou Montserrat Anguita Matteo L. Innocenti Nicole Bozzi Cionci Elisa Pettenati Jordi Tarrés‐Call |
| author_facet | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Roberto Edoardo Villa Giovanna Azimonti Eleftherios Bonos Henrik Christensen Mojca Durjava Birgit Dusemund Ronette Gehring Boet Glandorf Maryline Kouba Marta López‐Alonso Francesca Marcon Carlo Nebbia Alena Pechová Miguel Prieto‐Maradona Ilen Röhe Katerina Theodoridou Montserrat Anguita Matteo L. Innocenti Nicole Bozzi Cionci Elisa Pettenati Jordi Tarrés‐Call |
| author_sort | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) |
| collection | DOAJ |
| description | Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐lysine sulfate produced by fermentation with a non‐genetically modified strain of Corynebacterium glutamicum (CGMCC 23982) when used as a nutritional additive in feed for all animal species. The active substance is l‐lysine. The FEEDAP Panel concluded that the production strain qualifies for the qualified presumption of safety (QPS) approach to safety assessment; therefore, l‐lysine sulfate produced with C. glutamicum CGMCC 23982 does not pose any safety concern associated with the production strain. l‐Lysine sulfate produced with C. glutamicum CGMCC 23982 is considered safe for the target species when administered via feed. When using l‐lysine sulfate, the background sulfur/sulfate content in the compound feed should be taken into account when formulating diets. The FEEDAP Panel has concerns on the use of l‐lysine sulfate in water for drinking. l‐Lysine sulfate produced with C. glutamicum CGMCC 23982 is safe for the consumer and for the environment. With regard to user safety, the additive should be considered irritant to skin, eyes and the respiratory tract. Any exposure to the additive is a risk. l‐lysine sulfate is considered as an efficacious source of the essential amino acid l‐lysine for non‐ruminant animal species. For the supplemental l‐lysine to be as efficacious in ruminants as in non‐ruminant species, it would require protection against degradation in the rumen. |
| format | Article |
| id | doaj-art-ce32ef6cb2ac427dbbc378af17388051 |
| institution | Kabale University |
| issn | 1831-4732 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj-art-ce32ef6cb2ac427dbbc378af173880512025-08-20T03:33:17ZengWileyEFSA Journal1831-47322025-04-01234n/an/a10.2903/j.efsa.2025.9346Safety and efficacy of a feed additive consisting of l‐lysine sulfate produced with Corynebacterium glutamicum CGMCC 23982 for all animal species (Eppen Europa SAS)EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Roberto Edoardo VillaGiovanna AzimontiEleftherios BonosHenrik ChristensenMojca DurjavaBirgit DusemundRonette GehringBoet GlandorfMaryline KoubaMarta López‐AlonsoFrancesca MarconCarlo NebbiaAlena PechováMiguel Prieto‐MaradonaIlen RöheKaterina TheodoridouMontserrat AnguitaMatteo L. InnocentiNicole Bozzi CionciElisa PettenatiJordi Tarrés‐CallAbstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐lysine sulfate produced by fermentation with a non‐genetically modified strain of Corynebacterium glutamicum (CGMCC 23982) when used as a nutritional additive in feed for all animal species. The active substance is l‐lysine. The FEEDAP Panel concluded that the production strain qualifies for the qualified presumption of safety (QPS) approach to safety assessment; therefore, l‐lysine sulfate produced with C. glutamicum CGMCC 23982 does not pose any safety concern associated with the production strain. l‐Lysine sulfate produced with C. glutamicum CGMCC 23982 is considered safe for the target species when administered via feed. When using l‐lysine sulfate, the background sulfur/sulfate content in the compound feed should be taken into account when formulating diets. The FEEDAP Panel has concerns on the use of l‐lysine sulfate in water for drinking. l‐Lysine sulfate produced with C. glutamicum CGMCC 23982 is safe for the consumer and for the environment. With regard to user safety, the additive should be considered irritant to skin, eyes and the respiratory tract. Any exposure to the additive is a risk. l‐lysine sulfate is considered as an efficacious source of the essential amino acid l‐lysine for non‐ruminant animal species. For the supplemental l‐lysine to be as efficacious in ruminants as in non‐ruminant species, it would require protection against degradation in the rumen.https://doi.org/10.2903/j.efsa.2025.9346amino acidCGMCC 23982Corynebacterium glutamicumefficacylysine sulfatenutritional additive |
| spellingShingle | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Roberto Edoardo Villa Giovanna Azimonti Eleftherios Bonos Henrik Christensen Mojca Durjava Birgit Dusemund Ronette Gehring Boet Glandorf Maryline Kouba Marta López‐Alonso Francesca Marcon Carlo Nebbia Alena Pechová Miguel Prieto‐Maradona Ilen Röhe Katerina Theodoridou Montserrat Anguita Matteo L. Innocenti Nicole Bozzi Cionci Elisa Pettenati Jordi Tarrés‐Call Safety and efficacy of a feed additive consisting of l‐lysine sulfate produced with Corynebacterium glutamicum CGMCC 23982 for all animal species (Eppen Europa SAS) EFSA Journal amino acid CGMCC 23982 Corynebacterium glutamicum efficacy lysine sulfate nutritional additive |
| title | Safety and efficacy of a feed additive consisting of l‐lysine sulfate produced with Corynebacterium glutamicum CGMCC 23982 for all animal species (Eppen Europa SAS) |
| title_full | Safety and efficacy of a feed additive consisting of l‐lysine sulfate produced with Corynebacterium glutamicum CGMCC 23982 for all animal species (Eppen Europa SAS) |
| title_fullStr | Safety and efficacy of a feed additive consisting of l‐lysine sulfate produced with Corynebacterium glutamicum CGMCC 23982 for all animal species (Eppen Europa SAS) |
| title_full_unstemmed | Safety and efficacy of a feed additive consisting of l‐lysine sulfate produced with Corynebacterium glutamicum CGMCC 23982 for all animal species (Eppen Europa SAS) |
| title_short | Safety and efficacy of a feed additive consisting of l‐lysine sulfate produced with Corynebacterium glutamicum CGMCC 23982 for all animal species (Eppen Europa SAS) |
| title_sort | safety and efficacy of a feed additive consisting of l lysine sulfate produced with corynebacterium glutamicum cgmcc 23982 for all animal species eppen europa sas |
| topic | amino acid CGMCC 23982 Corynebacterium glutamicum efficacy lysine sulfate nutritional additive |
| url | https://doi.org/10.2903/j.efsa.2025.9346 |
| work_keys_str_mv | AT efsapanelonadditivesandproductsorsubstancesusedinanimalfeedfeedap safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT robertoedoardovilla safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT giovannaazimonti safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT eleftheriosbonos safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT henrikchristensen safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT mojcadurjava safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT birgitdusemund safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT ronettegehring safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT boetglandorf safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT marylinekouba safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT martalopezalonso safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT francescamarcon safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT carlonebbia safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT alenapechova safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT miguelprietomaradona safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT ilenrohe safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT katerinatheodoridou safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT montserratanguita safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT matteolinnocenti safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT nicolebozzicionci safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT elisapettenati safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas AT jorditarrescall safetyandefficacyofafeedadditiveconsistingofllysinesulfateproducedwithcorynebacteriumglutamicumcgmcc23982forallanimalspecieseppeneuropasas |