p27<sup>Kip1</sup> and Tumors: Characterization of <i>CDKN1B</i> Variants Identified in MEN4 and Breast Cancer

p27<sup>Kip1</sup> and Tumors: Characterization of <i>CDKN1B</i> Variants Identified in MEN4 and Breast Cancer

p27<sup>Kip1</sup> is a key cell cycle gatekeeper governing the timing of Cyclin-dependent kinase (CDK) activation/inactivation and, consequently, cell proliferation. Structurally, the protein is largely unfolded, a feature that strongly increases its plasticity and interactors and enhan...

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Bibliographic Details
Main Authors: Debora Bencivenga, Emanuela Stampone, Jahanzaib Azhar, Daniela Parente, Waqar Ali, Vitale Del Vecchio, Fulvio Della Ragione, Adriana Borriello
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
p27<sup>Kip1</sup>
<i>CDKN1B</i>
cell cycle
cell motility
tumor suppressor gene
cancer
Online Access:https://www.mdpi.com/2073-4409/14/3/188
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