EFFICACY OF SIMULTANEOUS INTENSIVE THERAPY IN PTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Abstract, Objective. To assess the synchronous intensive therapy (SIT) effect on clinical and laboratory signs in patients with systemic lupus erithematosus (SLE). Methods. SIT was performed in 30 SLE patients with unfavorable manifestation of the disease: lupus nephritis, neurolupus, cytopenia. The...
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IMA PRESS LLC
2002-02-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/887 |
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| author | E N Otteva A B Ostrovsky |
| author_facet | E N Otteva A B Ostrovsky |
| author_sort | E N Otteva |
| collection | DOAJ |
| description | Abstract, Objective. To assess the synchronous intensive therapy (SIT) effect on clinical and laboratory signs in patients with systemic lupus erithematosus (SLE). Methods. SIT was performed in 30 SLE patients with unfavorable manifestation of the disease: lupus nephritis, neurolupus, cytopenia. The first stage of the treatment consisted of 3 consecutive (PA) procedures with 4-5 days intervals. Alter each PA procedure mcthylprcdnisolone 1,0 was given and after the second one — cyclophosphane (Cph) 1,0, Prednisolone dose did not exceed 40 mg/day per os. During the second stage Cph 1,0 was giveu monthly and prednisolone dose was slowly diminished till 10 mg/day to the 3 month of the treatment. Clinical efficacy was assessed after 1 and 6 month of intensive treatment and then every year. Results. In all cases SIT provided fast decrease of the disease activity after the 1st month. By the end of the 1“ stage manifestations of the lupus vasculitis, nephritis, neurolupus and cytopenia disappeared. After 6 month 93,3% of patients achieved medication-induced stabilization. Complications were absent. Conclusion. SIT is a very effective and safe method of treatment of severe SLE forms. |
| format | Article |
| id | doaj-art-ce2cf6e6e4fa4c0cbcb2db50a42bfed1 |
| institution | Kabale University |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2002-02-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-ce2cf6e6e4fa4c0cbcb2db50a42bfed12025-08-20T04:00:39ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922002-02-01401535710.14412/1995-4484-2002-750827EFFICACY OF SIMULTANEOUS INTENSIVE THERAPY IN PTS WITH SYSTEMIC LUPUS ERYTHEMATOSUSE N OttevaA B OstrovskyAbstract, Objective. To assess the synchronous intensive therapy (SIT) effect on clinical and laboratory signs in patients with systemic lupus erithematosus (SLE). Methods. SIT was performed in 30 SLE patients with unfavorable manifestation of the disease: lupus nephritis, neurolupus, cytopenia. The first stage of the treatment consisted of 3 consecutive (PA) procedures with 4-5 days intervals. Alter each PA procedure mcthylprcdnisolone 1,0 was given and after the second one — cyclophosphane (Cph) 1,0, Prednisolone dose did not exceed 40 mg/day per os. During the second stage Cph 1,0 was giveu monthly and prednisolone dose was slowly diminished till 10 mg/day to the 3 month of the treatment. Clinical efficacy was assessed after 1 and 6 month of intensive treatment and then every year. Results. In all cases SIT provided fast decrease of the disease activity after the 1st month. By the end of the 1“ stage manifestations of the lupus vasculitis, nephritis, neurolupus and cytopenia disappeared. After 6 month 93,3% of patients achieved medication-induced stabilization. Complications were absent. Conclusion. SIT is a very effective and safe method of treatment of severe SLE forms.https://rsp.mediar-press.net/rsp/article/view/887systemic lupus erythematosuslupus nephritisneurolupussynchronous intensive therapyplasmapheresisprednisolonecvclophosphane. medication-induced stabilization |
| spellingShingle | E N Otteva A B Ostrovsky EFFICACY OF SIMULTANEOUS INTENSIVE THERAPY IN PTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS Научно-практическая ревматология systemic lupus erythematosus lupus nephritis neurolupus synchronous intensive therapy plasmapheresis prednisolone cvclophosphane. medication-induced stabilization |
| title | EFFICACY OF SIMULTANEOUS INTENSIVE THERAPY IN PTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS |
| title_full | EFFICACY OF SIMULTANEOUS INTENSIVE THERAPY IN PTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS |
| title_fullStr | EFFICACY OF SIMULTANEOUS INTENSIVE THERAPY IN PTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS |
| title_full_unstemmed | EFFICACY OF SIMULTANEOUS INTENSIVE THERAPY IN PTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS |
| title_short | EFFICACY OF SIMULTANEOUS INTENSIVE THERAPY IN PTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS |
| title_sort | efficacy of simultaneous intensive therapy in pts with systemic lupus erythematosus |
| topic | systemic lupus erythematosus lupus nephritis neurolupus synchronous intensive therapy plasmapheresis prednisolone cvclophosphane. medication-induced stabilization |
| url | https://rsp.mediar-press.net/rsp/article/view/887 |
| work_keys_str_mv | AT enotteva efficacyofsimultaneousintensivetherapyinptswithsystemiclupuserythematosus AT abostrovsky efficacyofsimultaneousintensivetherapyinptswithsystemiclupuserythematosus |