Multidrug resistant Salmonella Concord is a major cause of salmonellosis in children in Ethiopia
Introduction: S. Concord in Ethiopia. The objective of this study was to determine the aetiology of febrile and diarrhoeic illness in Ethiopian children focussing on Salmonella. Methodology: Paediatric patients (n = 1,225) presenting with diarrhoea or fever from the paediatric outpatient departme...
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The Journal of Infection in Developing Countries
2011-01-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/906 |
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| author | Getenet Beyene Satheesh Nair Daniel Asrat Yohannes Mengistu Howard Engers John Wain |
| author_facet | Getenet Beyene Satheesh Nair Daniel Asrat Yohannes Mengistu Howard Engers John Wain |
| author_sort | Getenet Beyene |
| collection | DOAJ |
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Introduction: S. Concord in Ethiopia. The objective of this study was to determine the aetiology of febrile and diarrhoeic illness in Ethiopian children focussing on Salmonella.
Methodology: Paediatric patients (n = 1,225) presenting with diarrhoea or fever from the paediatric outpatient department of Tikur Anbessa University Hospital, Addis Ababa (n = 825), and Jimma University Hospital, South West Ethiopia (n = 400), were investigated for pathogens from January to August 2006.
Results: Parasites were detected in 337 cases, Salmonella in 65, and Shigella in 61. Serotyping of Salmonella (including 48 stored isolates) demonstrated the dominance of S. Concord: S. Concord (85), S. Typhimurium (7), S. Paratyphi B (2), S. Haifa (1), S. Typhi (2), S. Enteritidis (4), S. Butantan (2), S. Infantis (1), S. Pomona (1), Salmonella group M (28:y:-) (1), and S. Oskarshamn (1). Six isolates in serogroups B and D were untypeable. Of 81 S. Concord isolates, 30% were invasive, most (86.5%) were positive for ESBL production by E-test and 70% were multiply resistant to trimethoprim-sulphamethaxole, ceftriaxone, chloramphenicol and gentamicin, of which over one quarter (27%) also showed reduced susceptibility to ciprofloxacin.
Conclusion: Multi-drug resistant S. Concord was the major cause of salmonellosis in two regions of Ethiopia. The strain isolated was highly invasive, highly antibiotic-resistant, and represents a threat to heath care globally.
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| format | Article |
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| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | The Journal of Infection in Developing Countries |
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| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-ce292d0dc8b94d78a4172f81ca60b3bf2025-08-20T02:27:23ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802011-01-0150110.3855/jidc.906Multidrug resistant Salmonella Concord is a major cause of salmonellosis in children in EthiopiaGetenet Beyene0Satheesh Nair1Daniel Asrat2Yohannes Mengistu3Howard Engers4John Wain5Department of Medical Microbiology, Immunology and Parasitology, Jimma, University,Laboratory for Gastrointestinal Pathogens, HPA, ColindaleDepartment of Medical Microbiology, Immunology and Parasitology, Addis Ababa, UniversityDepartment of Medical Microbiology, Immunology and Parasitology, Addis Ababa, UniversityArmauer Hansen Research Institute, Addis Ababa, EthiopiaLaboratory for Gastrointestinal Pathogens, HPA, Colindale Introduction: S. Concord in Ethiopia. The objective of this study was to determine the aetiology of febrile and diarrhoeic illness in Ethiopian children focussing on Salmonella. Methodology: Paediatric patients (n = 1,225) presenting with diarrhoea or fever from the paediatric outpatient department of Tikur Anbessa University Hospital, Addis Ababa (n = 825), and Jimma University Hospital, South West Ethiopia (n = 400), were investigated for pathogens from January to August 2006. Results: Parasites were detected in 337 cases, Salmonella in 65, and Shigella in 61. Serotyping of Salmonella (including 48 stored isolates) demonstrated the dominance of S. Concord: S. Concord (85), S. Typhimurium (7), S. Paratyphi B (2), S. Haifa (1), S. Typhi (2), S. Enteritidis (4), S. Butantan (2), S. Infantis (1), S. Pomona (1), Salmonella group M (28:y:-) (1), and S. Oskarshamn (1). Six isolates in serogroups B and D were untypeable. Of 81 S. Concord isolates, 30% were invasive, most (86.5%) were positive for ESBL production by E-test and 70% were multiply resistant to trimethoprim-sulphamethaxole, ceftriaxone, chloramphenicol and gentamicin, of which over one quarter (27%) also showed reduced susceptibility to ciprofloxacin. Conclusion: Multi-drug resistant S. Concord was the major cause of salmonellosis in two regions of Ethiopia. The strain isolated was highly invasive, highly antibiotic-resistant, and represents a threat to heath care globally. https://jidc.org/index.php/journal/article/view/906SalmonellaConcordantibiotic resistanceantimicrobial agentsEthiopia |
| spellingShingle | Getenet Beyene Satheesh Nair Daniel Asrat Yohannes Mengistu Howard Engers John Wain Multidrug resistant Salmonella Concord is a major cause of salmonellosis in children in Ethiopia Journal of Infection in Developing Countries Salmonella Concord antibiotic resistance antimicrobial agents Ethiopia |
| title | Multidrug resistant Salmonella Concord is a major cause of salmonellosis in children in Ethiopia |
| title_full | Multidrug resistant Salmonella Concord is a major cause of salmonellosis in children in Ethiopia |
| title_fullStr | Multidrug resistant Salmonella Concord is a major cause of salmonellosis in children in Ethiopia |
| title_full_unstemmed | Multidrug resistant Salmonella Concord is a major cause of salmonellosis in children in Ethiopia |
| title_short | Multidrug resistant Salmonella Concord is a major cause of salmonellosis in children in Ethiopia |
| title_sort | multidrug resistant salmonella concord is a major cause of salmonellosis in children in ethiopia |
| topic | Salmonella Concord antibiotic resistance antimicrobial agents Ethiopia |
| url | https://jidc.org/index.php/journal/article/view/906 |
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