Genomic epidemiology and phenotypic characterization of Staphylococcus aureus isolated from atopic dermatitis patients in South China
Abstract Atopic dermatitis (AD) is a multifactorial, chronic relapsing disease. Staphylococcus aureus is the key microbial factor in AD, linked to disease activity. However, there is limited knowledge of genomic prevalence characteristics and phenotypic features of S. aureus in AD patients in China....
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Nature Portfolio
2025-02-01
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| author | Chao Yang Xiaowei Chen Min Li Wenchang Yuan Shunguang Li Dexing Han Junhui Feng Haimin Luo Minling Zheng Jiaqi Liang Cha Chen Pinghua Qu Song Li |
| author_facet | Chao Yang Xiaowei Chen Min Li Wenchang Yuan Shunguang Li Dexing Han Junhui Feng Haimin Luo Minling Zheng Jiaqi Liang Cha Chen Pinghua Qu Song Li |
| author_sort | Chao Yang |
| collection | DOAJ |
| description | Abstract Atopic dermatitis (AD) is a multifactorial, chronic relapsing disease. Staphylococcus aureus is the key microbial factor in AD, linked to disease activity. However, there is limited knowledge of genomic prevalence characteristics and phenotypic features of S. aureus in AD patients in China. We investigated 108 S. aureus of AD in China and globally publicly available genome sequences of 579 S. aureus of AD. Sequence type (ST) 7, ST15 and ST188 were the major lineages in China. Genes esaC, esxB, and sea were only detected in ST7, potentially contributing to its prevalence in AD. ST188 exhibited high virulence and adhesion, possibly due to the cna gene. Phylogenetic and population structure analysis revealed that 579 strains of global AD were classified into 15 sequence clusters (SCs), with SC5, SC2, and SC7 dominating. S. aureus of Chinese AD patients was mainly distributed in SC2, SC7, and SC12. Comparative genomic highlighted genes linked to AD, including enterotoxins (seh, selk, selq, entH), adhesion genes (fnbA, fnbB, sdrD, map, fib, narH). From China and global perspectives, we analyzed S. aureus’s genomic epidemic traits, phylogeny, and population structure in AD skin. These findings contribute to understanding S. aureus-host interactions and genomic diversity in AD. |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-ce282527ed5141ae818f518a33e5afa82025-02-09T12:31:33ZengNature PortfolioScientific Reports2045-23222025-02-0115111210.1038/s41598-025-87317-9Genomic epidemiology and phenotypic characterization of Staphylococcus aureus isolated from atopic dermatitis patients in South ChinaChao Yang0Xiaowei Chen1Min Li2Wenchang Yuan3Shunguang Li4Dexing Han5Junhui Feng6Haimin Luo7Minling Zheng8Jiaqi Liang9Cha Chen10Pinghua Qu11Song Li12The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Clinical Laboratory/State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangdong Provincial Hospital of Chinese MedicineDepartment of Laboratory Medicine, Panyu Hospital of Chinese Medicine, Guangzhou University of Chinese MedicineSun Yat-sen University Cancer CenterGuangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, King Med School of Laboratory Medicine, Guangzhou Medical UniversityThe Second Clinical Medical College, Guangzhou University of Chinese Medicine, Clinical Laboratory/State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangdong Provincial Hospital of Chinese MedicineDepartment of Clinical Laboratory, The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou Kingmylab Pharmaceutical Research Co., Ltd.The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Clinical Laboratory/State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangdong Provincial Hospital of Chinese MedicineDepartment of Clinical Laboratory, Guangdong Women and Children HospitalGuangzhou Panyu District Health Management Center (Panyu District Rehabilitation Hospital)The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Clinical Laboratory/State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangdong Provincial Hospital of Chinese MedicineSchool of Medicine, Foshan UniversityThe Second Clinical Medical College, Guangzhou University of Chinese Medicine, Clinical Laboratory/State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangdong Provincial Hospital of Chinese MedicineAbstract Atopic dermatitis (AD) is a multifactorial, chronic relapsing disease. Staphylococcus aureus is the key microbial factor in AD, linked to disease activity. However, there is limited knowledge of genomic prevalence characteristics and phenotypic features of S. aureus in AD patients in China. We investigated 108 S. aureus of AD in China and globally publicly available genome sequences of 579 S. aureus of AD. Sequence type (ST) 7, ST15 and ST188 were the major lineages in China. Genes esaC, esxB, and sea were only detected in ST7, potentially contributing to its prevalence in AD. ST188 exhibited high virulence and adhesion, possibly due to the cna gene. Phylogenetic and population structure analysis revealed that 579 strains of global AD were classified into 15 sequence clusters (SCs), with SC5, SC2, and SC7 dominating. S. aureus of Chinese AD patients was mainly distributed in SC2, SC7, and SC12. Comparative genomic highlighted genes linked to AD, including enterotoxins (seh, selk, selq, entH), adhesion genes (fnbA, fnbB, sdrD, map, fib, narH). From China and global perspectives, we analyzed S. aureus’s genomic epidemic traits, phylogeny, and population structure in AD skin. These findings contribute to understanding S. aureus-host interactions and genomic diversity in AD.https://doi.org/10.1038/s41598-025-87317-9Atopic dermatitisStaphylococcus aureusWhole-genome sequencingPhylogenetic analysisPGWAS |
| spellingShingle | Chao Yang Xiaowei Chen Min Li Wenchang Yuan Shunguang Li Dexing Han Junhui Feng Haimin Luo Minling Zheng Jiaqi Liang Cha Chen Pinghua Qu Song Li Genomic epidemiology and phenotypic characterization of Staphylococcus aureus isolated from atopic dermatitis patients in South China Scientific Reports Atopic dermatitis Staphylococcus aureus Whole-genome sequencing Phylogenetic analysis PGWAS |
| title | Genomic epidemiology and phenotypic characterization of Staphylococcus aureus isolated from atopic dermatitis patients in South China |
| title_full | Genomic epidemiology and phenotypic characterization of Staphylococcus aureus isolated from atopic dermatitis patients in South China |
| title_fullStr | Genomic epidemiology and phenotypic characterization of Staphylococcus aureus isolated from atopic dermatitis patients in South China |
| title_full_unstemmed | Genomic epidemiology and phenotypic characterization of Staphylococcus aureus isolated from atopic dermatitis patients in South China |
| title_short | Genomic epidemiology and phenotypic characterization of Staphylococcus aureus isolated from atopic dermatitis patients in South China |
| title_sort | genomic epidemiology and phenotypic characterization of staphylococcus aureus isolated from atopic dermatitis patients in south china |
| topic | Atopic dermatitis Staphylococcus aureus Whole-genome sequencing Phylogenetic analysis PGWAS |
| url | https://doi.org/10.1038/s41598-025-87317-9 |
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