Metabolic reprogramming of peritoneal mesothelial cells in peritoneal dialysis–associated fibrosis: therapeutic targets and strategies

Abstract Peritoneal dialysis (PD) is considered a life-saving treatment for end-stage renal disease. However, prolonged PD use can lead to the development of peritoneal fibrosis (PF), diminishing its efficacy. Peritoneal mesothelial cells (PMCs) are key initiators of PF when they become damaged. Exp...

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Main Authors: Fang Yu, Jia Chen, Xiaoyue Wang, Shihui Hou, Hong Li, Yaru Yao, Yani He, Kehong Chen
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cell Communication and Signaling
Subjects:
Online Access:https://doi.org/10.1186/s12964-025-02113-2
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author Fang Yu
Jia Chen
Xiaoyue Wang
Shihui Hou
Hong Li
Yaru Yao
Yani He
Kehong Chen
author_facet Fang Yu
Jia Chen
Xiaoyue Wang
Shihui Hou
Hong Li
Yaru Yao
Yani He
Kehong Chen
author_sort Fang Yu
collection DOAJ
description Abstract Peritoneal dialysis (PD) is considered a life-saving treatment for end-stage renal disease. However, prolonged PD use can lead to the development of peritoneal fibrosis (PF), diminishing its efficacy. Peritoneal mesothelial cells (PMCs) are key initiators of PF when they become damaged. Exposure to high glucose‑based peritoneal dialysis fluids (PDFs) contributes to PF development by directly affecting highly metabolically active PMCs. Recent research indicates that PMCs undergo metabolic reprogramming when exposed to high-glucose PDFs, including enhanced glycolysis, impaired oxidative phosphorylation, abnormal lipid metabolism, and mitochondrial dysfunction. Although this metabolic transition temporarily compensates for the cellular damage and maintains energy levels, its long-term impact on peritoneal tissue is concerning. Multiple studies have identified a close association between this shift in energy metabolism and PF, and may promote the progression of PF through various molecular mechanisms. This review explores recent findings regarding the role and mechanism of PMC metabolic reprogramming in PF progression. Moreover, it provides a summary of potential therapeutic strategies aimed at various metabolic processes, including glucose metabolism, lipid metabolism, and mitochondrial function. The review establishes that targeting metabolic reprogramming in PMCs may be a novel strategy for preventing and treating PD-associated fibrosis.
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issn 1478-811X
language English
publishDate 2025-02-01
publisher BMC
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series Cell Communication and Signaling
spelling doaj-art-ce25bea027aa4877930a2d0f67b2050a2025-08-20T02:33:32ZengBMCCell Communication and Signaling1478-811X2025-02-0123111710.1186/s12964-025-02113-2Metabolic reprogramming of peritoneal mesothelial cells in peritoneal dialysis–associated fibrosis: therapeutic targets and strategiesFang Yu0Jia Chen1Xiaoyue Wang2Shihui Hou3Hong Li4Yaru Yao5Yani He6Kehong Chen7Department of Nephrology, Daping Hospital, Army Medical Center, Army Medical UniversityDepartment of Nephrology, Daping Hospital, Army Medical Center, Army Medical UniversityDepartment of Nephrology, Daping Hospital, Army Medical Center, Army Medical UniversityDepartment of Nephrology, Daping Hospital, Army Medical Center, Army Medical UniversityDepartment of Nephrology, Daping Hospital, Army Medical Center, Army Medical UniversityDepartment of Nephrology, Daping Hospital, Army Medical Center, Army Medical UniversityDepartment of Nephrology, Daping Hospital, Army Medical Center, Army Medical UniversityDepartment of Nephrology, Daping Hospital, Army Medical Center, Army Medical UniversityAbstract Peritoneal dialysis (PD) is considered a life-saving treatment for end-stage renal disease. However, prolonged PD use can lead to the development of peritoneal fibrosis (PF), diminishing its efficacy. Peritoneal mesothelial cells (PMCs) are key initiators of PF when they become damaged. Exposure to high glucose‑based peritoneal dialysis fluids (PDFs) contributes to PF development by directly affecting highly metabolically active PMCs. Recent research indicates that PMCs undergo metabolic reprogramming when exposed to high-glucose PDFs, including enhanced glycolysis, impaired oxidative phosphorylation, abnormal lipid metabolism, and mitochondrial dysfunction. Although this metabolic transition temporarily compensates for the cellular damage and maintains energy levels, its long-term impact on peritoneal tissue is concerning. Multiple studies have identified a close association between this shift in energy metabolism and PF, and may promote the progression of PF through various molecular mechanisms. This review explores recent findings regarding the role and mechanism of PMC metabolic reprogramming in PF progression. Moreover, it provides a summary of potential therapeutic strategies aimed at various metabolic processes, including glucose metabolism, lipid metabolism, and mitochondrial function. The review establishes that targeting metabolic reprogramming in PMCs may be a novel strategy for preventing and treating PD-associated fibrosis.https://doi.org/10.1186/s12964-025-02113-2Metabolic reprogrammingPeritoneal mesothelial cellsPeritoneal dialysisPeritoneal fibrosisTherapeutic target
spellingShingle Fang Yu
Jia Chen
Xiaoyue Wang
Shihui Hou
Hong Li
Yaru Yao
Yani He
Kehong Chen
Metabolic reprogramming of peritoneal mesothelial cells in peritoneal dialysis–associated fibrosis: therapeutic targets and strategies
Cell Communication and Signaling
Metabolic reprogramming
Peritoneal mesothelial cells
Peritoneal dialysis
Peritoneal fibrosis
Therapeutic target
title Metabolic reprogramming of peritoneal mesothelial cells in peritoneal dialysis–associated fibrosis: therapeutic targets and strategies
title_full Metabolic reprogramming of peritoneal mesothelial cells in peritoneal dialysis–associated fibrosis: therapeutic targets and strategies
title_fullStr Metabolic reprogramming of peritoneal mesothelial cells in peritoneal dialysis–associated fibrosis: therapeutic targets and strategies
title_full_unstemmed Metabolic reprogramming of peritoneal mesothelial cells in peritoneal dialysis–associated fibrosis: therapeutic targets and strategies
title_short Metabolic reprogramming of peritoneal mesothelial cells in peritoneal dialysis–associated fibrosis: therapeutic targets and strategies
title_sort metabolic reprogramming of peritoneal mesothelial cells in peritoneal dialysis associated fibrosis therapeutic targets and strategies
topic Metabolic reprogramming
Peritoneal mesothelial cells
Peritoneal dialysis
Peritoneal fibrosis
Therapeutic target
url https://doi.org/10.1186/s12964-025-02113-2
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