Telomere length associations with cognition depend on Alzheimer's disease biomarkers
Abstract Introduction While telomere shortening, a marker of cellular aging, may impact the progression of age‐related neurodegenerative diseases, its association with cognition is unclear, particularly in the context of Alzheimer's disease (AD) pathology. Methods Telomere, cognitive, and CSF d...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
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| Online Access: | https://doi.org/10.1016/j.trci.2019.11.003 |
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| author | Emily R. Mahoney Logan Dumitrescu Mabel Seto Kelly N.H. Nudelman Rachel F. Buckley Katie A. Gifford Andrew J. Saykin Angela J. Jefferson Timothy J. Hohman Alzheimer's Disease Neuroimaging Initiative |
| author_facet | Emily R. Mahoney Logan Dumitrescu Mabel Seto Kelly N.H. Nudelman Rachel F. Buckley Katie A. Gifford Andrew J. Saykin Angela J. Jefferson Timothy J. Hohman Alzheimer's Disease Neuroimaging Initiative |
| author_sort | Emily R. Mahoney |
| collection | DOAJ |
| description | Abstract Introduction While telomere shortening, a marker of cellular aging, may impact the progression of age‐related neurodegenerative diseases, its association with cognition is unclear, particularly in the context of Alzheimer's disease (AD) pathology. Methods Telomere, cognitive, and CSF data from 482 participants in the AD Neuroimaging Initiative (148 cognitively normal, 283 mild cognitive impairment, 51 AD) was leveraged to assess telomere length associations with cognition (measured by memory and executive function) and interactions with CSF amyloid‐β, tau, and APOE‐ε4. Secondary analyses assessed brain volume and thickness outcomes. Results Longer telomeres at baseline were associated with faster executive function decline. Amyloid‐β and tau interacted with telomere length on cognition, with longer telomeres related to faster decline among biomarker‐positive individuals. Discussion Telomere associations with cognition shift with AD progression, with longer telomeres related to worse outcomes as pathology increases, highlighting the need for further investigation of telomere length along the AD neuropathological cascade. |
| format | Article |
| id | doaj-art-ce24736d0fc1497fbc9f2eac8fa14d6f |
| institution | OA Journals |
| issn | 2352-8737 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj-art-ce24736d0fc1497fbc9f2eac8fa14d6f2025-08-20T02:09:55ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372019-01-015188389010.1016/j.trci.2019.11.003Telomere length associations with cognition depend on Alzheimer's disease biomarkersEmily R. Mahoney0Logan Dumitrescu1Mabel Seto2Kelly N.H. Nudelman3Rachel F. Buckley4Katie A. Gifford5Andrew J. Saykin6Angela J. Jefferson7Timothy J. Hohman8Alzheimer's Disease Neuroimaging InitiativeVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical CenterNashvilleTNUSAVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical CenterNashvilleTNUSAVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical CenterNashvilleTNUSAIndiana Alzheimer Disease Center, Indiana University School of MedicineIndianapolisINUSADepartment of NeurologyMassachusetts General HospitalBostonMAUSAVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical CenterNashvilleTNUSADepartment of Radiology & Imaging SciencesIndiana University School of MedicineIndianapolisINUSAVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical CenterNashvilleTNUSAVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical CenterNashvilleTNUSAAbstract Introduction While telomere shortening, a marker of cellular aging, may impact the progression of age‐related neurodegenerative diseases, its association with cognition is unclear, particularly in the context of Alzheimer's disease (AD) pathology. Methods Telomere, cognitive, and CSF data from 482 participants in the AD Neuroimaging Initiative (148 cognitively normal, 283 mild cognitive impairment, 51 AD) was leveraged to assess telomere length associations with cognition (measured by memory and executive function) and interactions with CSF amyloid‐β, tau, and APOE‐ε4. Secondary analyses assessed brain volume and thickness outcomes. Results Longer telomeres at baseline were associated with faster executive function decline. Amyloid‐β and tau interacted with telomere length on cognition, with longer telomeres related to faster decline among biomarker‐positive individuals. Discussion Telomere associations with cognition shift with AD progression, with longer telomeres related to worse outcomes as pathology increases, highlighting the need for further investigation of telomere length along the AD neuropathological cascade.https://doi.org/10.1016/j.trci.2019.11.003APOEExecutive functionCognitionCSF biomarkersTelomeres |
| spellingShingle | Emily R. Mahoney Logan Dumitrescu Mabel Seto Kelly N.H. Nudelman Rachel F. Buckley Katie A. Gifford Andrew J. Saykin Angela J. Jefferson Timothy J. Hohman Alzheimer's Disease Neuroimaging Initiative Telomere length associations with cognition depend on Alzheimer's disease biomarkers Alzheimer’s & Dementia: Translational Research & Clinical Interventions APOE Executive function Cognition CSF biomarkers Telomeres |
| title | Telomere length associations with cognition depend on Alzheimer's disease biomarkers |
| title_full | Telomere length associations with cognition depend on Alzheimer's disease biomarkers |
| title_fullStr | Telomere length associations with cognition depend on Alzheimer's disease biomarkers |
| title_full_unstemmed | Telomere length associations with cognition depend on Alzheimer's disease biomarkers |
| title_short | Telomere length associations with cognition depend on Alzheimer's disease biomarkers |
| title_sort | telomere length associations with cognition depend on alzheimer s disease biomarkers |
| topic | APOE Executive function Cognition CSF biomarkers Telomeres |
| url | https://doi.org/10.1016/j.trci.2019.11.003 |
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