Feature selection enhances peptide binding predictions for TCR-specific interactions

Feature selection enhances peptide binding predictions for TCR-specific interactions

IntroductionT-cell receptors (TCRs) play a critical role in the immune response by recognizing specific ligand peptides presented by major histocompatibility complex (MHC) molecules. Accurate prediction of peptide binding to TCRs is essential for advancing immunotherapy, vaccine design, and understa...

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Bibliographic Details
Main Authors: Hamid Teimouri, Zahra S. Ghoreyshi, Anatoly B. Kolomeisky, Jason T. George
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
immune response
feature selection
physicochemical properties
TCR-peptide interactions
binding affinity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1510435/full
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