Adverse reproductive outcome induced by Parvovirus B19 and TORCH infections in women with high-risk pregnancy
Introduction: The frequency of fetopathogenic viruses and Toxoplasma gondii infections in the TORCH group (Toxoplasma gondii, rubella virus, cytomegalovirus (CMV), herpes simplex virus) together with Parvovirus B19 (B19) in pregnant women with bad obstetric history (BOH) and/or concurrent pregnancy...
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The Journal of Infection in Developing Countries
2011-11-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/1533 |
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| author | Janak Kishore Richa Misra Abhiruchi Paisal Yashodhra Pradeep |
| author_facet | Janak Kishore Richa Misra Abhiruchi Paisal Yashodhra Pradeep |
| author_sort | Janak Kishore |
| collection | DOAJ |
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Introduction: The frequency of fetopathogenic viruses and Toxoplasma gondii infections in the TORCH group (Toxoplasma gondii, rubella virus, cytomegalovirus (CMV), herpes simplex virus) together with Parvovirus B19 (B19) in pregnant women with bad obstetric history (BOH) and/or concurrent pregnancy complications was investigated.
Methodology: Sixty women (20-35 years) with BOH and/or antecedent pregnancy complications were studied. Twenty-nine healthy pregnant women matched for age, parity and gestational age served as controls. Sera were analyzed for IgM antibodies for B19 and TORCH agents by ELISA. Cord blood and 33 placental tissues from six malformed newborns were tested for B19 DNA by PCR.
Results: Out of 60 high-risk pregnant women, 47 (78%) had BOH while 23 (38.3%) had underlying complications including polyhydramnios (n=10), oligohydramnios (n=6) and intrauterine growth restriction (n=7). Adverse outcomes occurred in 36 (60%) high-risk cases. All 16 cases with polyhydramnios/oligohydramnios resulted in preterm stillbirths while the remaining 20 cases resulted in seven abortions, six newborns with congenital malformations, four full-term stillbirths and three cases of non-immune hydrops fetalis (NIHF). IgM positivity to T. gondii, rubella, cytomegalovirus, herpes simplex virus and B19 virus was 8.3%, 15%, 30%, 3.3% and 13.6% respectively. B19 infection caused NIHF in three cases and cardiac anomaly in one. All placental tissues and cord blood were negative for B19 DNA. None of the controls had IgM antibodies to any pathogen.
Conclusions: Women with BOH and/or pregnancy complications had a high frequency of TORCH and parvovirus B19 infections causing fetal wastage, IUGR, NIHF and congenital malformations.
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| format | Article |
| id | doaj-art-ce1f0a79e5614a9f98e7191cab462ccd |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2011-11-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-ce1f0a79e5614a9f98e7191cab462ccd2025-08-20T02:16:15ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802011-11-0151210.3855/jidc.1533Adverse reproductive outcome induced by Parvovirus B19 and TORCH infections in women with high-risk pregnancyJanak Kishore0Richa Misra1Abhiruchi Paisal2Yashodhra Pradeep3Department of Microbiolgy, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, IndiaDepartment of Microbiolgy, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, IndiaDepartment of Obstetrics and Gynecology, C S M Medical University, Lucknow, IndiaDepartment of Obstetrics and Gynecology, C S M Medical University, Lucknow, India Introduction: The frequency of fetopathogenic viruses and Toxoplasma gondii infections in the TORCH group (Toxoplasma gondii, rubella virus, cytomegalovirus (CMV), herpes simplex virus) together with Parvovirus B19 (B19) in pregnant women with bad obstetric history (BOH) and/or concurrent pregnancy complications was investigated. Methodology: Sixty women (20-35 years) with BOH and/or antecedent pregnancy complications were studied. Twenty-nine healthy pregnant women matched for age, parity and gestational age served as controls. Sera were analyzed for IgM antibodies for B19 and TORCH agents by ELISA. Cord blood and 33 placental tissues from six malformed newborns were tested for B19 DNA by PCR. Results: Out of 60 high-risk pregnant women, 47 (78%) had BOH while 23 (38.3%) had underlying complications including polyhydramnios (n=10), oligohydramnios (n=6) and intrauterine growth restriction (n=7). Adverse outcomes occurred in 36 (60%) high-risk cases. All 16 cases with polyhydramnios/oligohydramnios resulted in preterm stillbirths while the remaining 20 cases resulted in seven abortions, six newborns with congenital malformations, four full-term stillbirths and three cases of non-immune hydrops fetalis (NIHF). IgM positivity to T. gondii, rubella, cytomegalovirus, herpes simplex virus and B19 virus was 8.3%, 15%, 30%, 3.3% and 13.6% respectively. B19 infection caused NIHF in three cases and cardiac anomaly in one. All placental tissues and cord blood were negative for B19 DNA. None of the controls had IgM antibodies to any pathogen. Conclusions: Women with BOH and/or pregnancy complications had a high frequency of TORCH and parvovirus B19 infections causing fetal wastage, IUGR, NIHF and congenital malformations. https://jidc.org/index.php/journal/article/view/1533abortionBOHcongenital malformationhydrops fetalisParvovirus B19pregnancy complications |
| spellingShingle | Janak Kishore Richa Misra Abhiruchi Paisal Yashodhra Pradeep Adverse reproductive outcome induced by Parvovirus B19 and TORCH infections in women with high-risk pregnancy Journal of Infection in Developing Countries abortion BOH congenital malformation hydrops fetalis Parvovirus B19 pregnancy complications |
| title | Adverse reproductive outcome induced by Parvovirus B19 and TORCH infections in women with high-risk pregnancy |
| title_full | Adverse reproductive outcome induced by Parvovirus B19 and TORCH infections in women with high-risk pregnancy |
| title_fullStr | Adverse reproductive outcome induced by Parvovirus B19 and TORCH infections in women with high-risk pregnancy |
| title_full_unstemmed | Adverse reproductive outcome induced by Parvovirus B19 and TORCH infections in women with high-risk pregnancy |
| title_short | Adverse reproductive outcome induced by Parvovirus B19 and TORCH infections in women with high-risk pregnancy |
| title_sort | adverse reproductive outcome induced by parvovirus b19 and torch infections in women with high risk pregnancy |
| topic | abortion BOH congenital malformation hydrops fetalis Parvovirus B19 pregnancy complications |
| url | https://jidc.org/index.php/journal/article/view/1533 |
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