Association of patient tumour characteristics and 5-Year survival in women with breast cancer in Nigeria: A retrospective cohort study
Objective: The sociodemographic and biological profiles of breast cancer differ globally, especially in women of African descent. In Nigeria, limited studies explore the impact of these breast cancer-related factors on survival. This study evaluated the association between patients' tumour cha...
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| Format: | Article |
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Babcock Medical Society
2025-06-01
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| Series: | Babcock University Medical Journal |
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| Online Access: | https://bumj.babcock.edu.ng/index.php/bumj/article/view/619 |
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| author | Omolara Fatiregun Nwamaka N Lasebikan Emmanella Nwachukwu Boluwatife Borisade Jimoh Mutiu Anthonia C Sowunmi Nnodimele Atulomah |
| author_facet | Omolara Fatiregun Nwamaka N Lasebikan Emmanella Nwachukwu Boluwatife Borisade Jimoh Mutiu Anthonia C Sowunmi Nnodimele Atulomah |
| author_sort | Omolara Fatiregun |
| collection | DOAJ |
| description |
Objective: The sociodemographic and biological profiles of breast cancer differ globally, especially in women of African descent. In Nigeria, limited studies explore the impact of these breast cancer-related factors on survival. This study evaluated the association between patients' tumour characteristics and survival in breast cancer patients in three regional tertiary cancer treatment centres across Nigeria.
Methodology: Data were extracted from patients' case files with a histopathologic diagnosis of breast cancer from January 1, 2005, to January 1, 2019. Patients' sociodemographic and clinical features were presented, and survival probabilities were reported; the Log-rank test was used to determine the association between time to death and categorical variables.
Results: The study included 1020 patients across the three centres. The five-year survival probability was 0.65, and the 95% C.I. was 0.60- 0.69. Most patients were between the ages of 30 and 49, and 49% presented with left-sided breast cancer. Patients aged>70 had significantly better survival. Only 40% had Immunohistochemistry (IHC) done, out of which HR+ breast cancer accounted for 43%, while triple-negative breast cancer was 30%. Patients who received Herceptin and had molecular subtyping (immunohistochemistry) done had a higher survival probability.
Conclusions: Most breast cancer patients in Nigeria present at earlier ages with advanced disease, and the 5-year survival rates are lower than global rates. Only a few patients have access to optimal breast cancer management. There is an urgent need to provide equitable access to cancer treatment by scaling up the implementation of the strategic framework on breast cancer screening and management.
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| format | Article |
| id | doaj-art-ce1eb6b8be2646d39f90b2f2bbb0bdbc |
| institution | DOAJ |
| issn | 2465-6666 2756-4657 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Babcock Medical Society |
| record_format | Article |
| series | Babcock University Medical Journal |
| spelling | doaj-art-ce1eb6b8be2646d39f90b2f2bbb0bdbc2025-08-20T03:15:47ZengBabcock Medical SocietyBabcock University Medical Journal2465-66662756-46572025-06-018110.38029/babcockuniv.med.j..v8i1.619Association of patient tumour characteristics and 5-Year survival in women with breast cancer in Nigeria: A retrospective cohort studyOmolara Fatiregun0Nwamaka N Lasebikan1Emmanella Nwachukwu2Boluwatife Borisade3Jimoh Mutiu4Anthonia C Sowunmi5Nnodimele Atulomah6Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, CanadaDepartment of Radiation Medicine, University of Nigeria Teaching Hospital, Enugu, NigeriaDepartment of Radiotherapy and Oncology, National Hospital Abuja, Abuja, NigeriaCancer Explore Foundation, Lagos, NigeriaLakeshore Cancer Centre, Lagos, NigeriaDepartment of Radiation Biology, Radiotherapy, Radiodiagnosis and Radiography, College of Medicine, University of Lagos, Lagos, NigeriaSchool of Public and Allied Health, Babcock University, Ogun State, Nigeria Objective: The sociodemographic and biological profiles of breast cancer differ globally, especially in women of African descent. In Nigeria, limited studies explore the impact of these breast cancer-related factors on survival. This study evaluated the association between patients' tumour characteristics and survival in breast cancer patients in three regional tertiary cancer treatment centres across Nigeria. Methodology: Data were extracted from patients' case files with a histopathologic diagnosis of breast cancer from January 1, 2005, to January 1, 2019. Patients' sociodemographic and clinical features were presented, and survival probabilities were reported; the Log-rank test was used to determine the association between time to death and categorical variables. Results: The study included 1020 patients across the three centres. The five-year survival probability was 0.65, and the 95% C.I. was 0.60- 0.69. Most patients were between the ages of 30 and 49, and 49% presented with left-sided breast cancer. Patients aged>70 had significantly better survival. Only 40% had Immunohistochemistry (IHC) done, out of which HR+ breast cancer accounted for 43%, while triple-negative breast cancer was 30%. Patients who received Herceptin and had molecular subtyping (immunohistochemistry) done had a higher survival probability. Conclusions: Most breast cancer patients in Nigeria present at earlier ages with advanced disease, and the 5-year survival rates are lower than global rates. Only a few patients have access to optimal breast cancer management. There is an urgent need to provide equitable access to cancer treatment by scaling up the implementation of the strategic framework on breast cancer screening and management. https://bumj.babcock.edu.ng/index.php/bumj/article/view/619Breast cancerSurvivalNigeria |
| spellingShingle | Omolara Fatiregun Nwamaka N Lasebikan Emmanella Nwachukwu Boluwatife Borisade Jimoh Mutiu Anthonia C Sowunmi Nnodimele Atulomah Association of patient tumour characteristics and 5-Year survival in women with breast cancer in Nigeria: A retrospective cohort study Babcock University Medical Journal Breast cancer Survival Nigeria |
| title | Association of patient tumour characteristics and 5-Year survival in women with breast cancer in Nigeria: A retrospective cohort study |
| title_full | Association of patient tumour characteristics and 5-Year survival in women with breast cancer in Nigeria: A retrospective cohort study |
| title_fullStr | Association of patient tumour characteristics and 5-Year survival in women with breast cancer in Nigeria: A retrospective cohort study |
| title_full_unstemmed | Association of patient tumour characteristics and 5-Year survival in women with breast cancer in Nigeria: A retrospective cohort study |
| title_short | Association of patient tumour characteristics and 5-Year survival in women with breast cancer in Nigeria: A retrospective cohort study |
| title_sort | association of patient tumour characteristics and 5 year survival in women with breast cancer in nigeria a retrospective cohort study |
| topic | Breast cancer Survival Nigeria |
| url | https://bumj.babcock.edu.ng/index.php/bumj/article/view/619 |
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