Binding memory of liquid molecules
Abstract Understanding the binding dynamics of liquid molecules is of fundamental importance in physical and life sciences. However, nanoscale fast dynamics pose great challenges for experimental characterization. Conventionally, the binding dynamics have been assumed to be memoryless. Here, we inte...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-61630-3 |
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| _version_ | 1849332185167822848 |
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| author | Shiyi Qin Zhi Yang Huimin Liu Xiaoli Wang Bing Miao Shangguo Hou Kai Huang |
| author_facet | Shiyi Qin Zhi Yang Huimin Liu Xiaoli Wang Bing Miao Shangguo Hou Kai Huang |
| author_sort | Shiyi Qin |
| collection | DOAJ |
| description | Abstract Understanding the binding dynamics of liquid molecules is of fundamental importance in physical and life sciences. However, nanoscale fast dynamics pose great challenges for experimental characterization. Conventionally, the binding dynamics have been assumed to be memoryless. Here, we integrate large scale computer simulation, scaling theory, and real-time single particle tracking microscopy with high spatiotemporal precision to unveil a universal memory effect in the binding dynamics of liquid molecules. This binding memory can be quantified by a binding time autocorrelation function, whose power-law decay depends on binding affinity, the topological and materials properties of the surrounding environment and the heterogeneity of the binding landscape. Context-dependent biomolecular binding memory is likely exploited by biological systems to regulate biochemical reactions and biophysical processes. Deciphering this binding memory offers a novel strategy to probe complex biological systems and advanced soft materials. |
| format | Article |
| id | doaj-art-ce1afb9efba147ebb0f87b46112e8418 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-ce1afb9efba147ebb0f87b46112e84182025-08-20T03:46:17ZengNature PortfolioNature Communications2041-17232025-07-0116111510.1038/s41467-025-61630-3Binding memory of liquid moleculesShiyi Qin0Zhi Yang1Huimin Liu2Xiaoli Wang3Bing Miao4Shangguo Hou5Kai Huang6Institute of Systems and Physical Biology, Shenzhen Bay LaboratoryInstitute of Systems and Physical Biology, Shenzhen Bay LaboratoryInstitute of Systems and Physical Biology, Shenzhen Bay LaboratoryInstitute of Systems and Physical Biology, Shenzhen Bay LaboratoryCenter of Materials Science and Optoelectronics Engineering, College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences (UCAS)Institute of Systems and Physical Biology, Shenzhen Bay LaboratoryInstitute of Systems and Physical Biology, Shenzhen Bay LaboratoryAbstract Understanding the binding dynamics of liquid molecules is of fundamental importance in physical and life sciences. However, nanoscale fast dynamics pose great challenges for experimental characterization. Conventionally, the binding dynamics have been assumed to be memoryless. Here, we integrate large scale computer simulation, scaling theory, and real-time single particle tracking microscopy with high spatiotemporal precision to unveil a universal memory effect in the binding dynamics of liquid molecules. This binding memory can be quantified by a binding time autocorrelation function, whose power-law decay depends on binding affinity, the topological and materials properties of the surrounding environment and the heterogeneity of the binding landscape. Context-dependent biomolecular binding memory is likely exploited by biological systems to regulate biochemical reactions and biophysical processes. Deciphering this binding memory offers a novel strategy to probe complex biological systems and advanced soft materials.https://doi.org/10.1038/s41467-025-61630-3 |
| spellingShingle | Shiyi Qin Zhi Yang Huimin Liu Xiaoli Wang Bing Miao Shangguo Hou Kai Huang Binding memory of liquid molecules Nature Communications |
| title | Binding memory of liquid molecules |
| title_full | Binding memory of liquid molecules |
| title_fullStr | Binding memory of liquid molecules |
| title_full_unstemmed | Binding memory of liquid molecules |
| title_short | Binding memory of liquid molecules |
| title_sort | binding memory of liquid molecules |
| url | https://doi.org/10.1038/s41467-025-61630-3 |
| work_keys_str_mv | AT shiyiqin bindingmemoryofliquidmolecules AT zhiyang bindingmemoryofliquidmolecules AT huiminliu bindingmemoryofliquidmolecules AT xiaoliwang bindingmemoryofliquidmolecules AT bingmiao bindingmemoryofliquidmolecules AT shangguohou bindingmemoryofliquidmolecules AT kaihuang bindingmemoryofliquidmolecules |