Unlocking Cellular Memory and Gene Regulatory Networks: Pioneering the Future of Therapeutic Innovations
Cellular memory is the competence of cells to preserve information from past experiences and respond aptly. This memory is maintained and controlled by gene regulatory networks (GRNs). GRNs are crucial for understanding why some cells are resistant to treatment, particularly for cancer. In our study...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/14/12/903 |
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| author | Md Sorique Aziz Momin Jhuma Bhadra Debmalya Bhunia Achinta Sannigrahi Nayan De |
| author_facet | Md Sorique Aziz Momin Jhuma Bhadra Debmalya Bhunia Achinta Sannigrahi Nayan De |
| author_sort | Md Sorique Aziz Momin |
| collection | DOAJ |
| description | Cellular memory is the competence of cells to preserve information from past experiences and respond aptly. This memory is maintained and controlled by gene regulatory networks (GRNs). GRNs are crucial for understanding why some cells are resistant to treatment, particularly for cancer. In our study, we created a new mathematical model to understand how “noise” affects cellular memory in GRNs, focusing on a “double positive feedback loop”. Our theoretical perspective article equipped with mathematical modeling exhibits how noise and feedback loops interact in GRNs. It also proposes a potential theoretical avenue for future therapy. By targeting the mechanisms that maintain drug resistance in cells, we aim to develop therapies that can restore the sensitivity of cancer cells to treatment. |
| format | Article |
| id | doaj-art-ce1a70a130524baabfa9c63ec56f07d1 |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-ce1a70a130524baabfa9c63ec56f07d12025-08-20T03:27:00ZengMDPI AGCells2073-44092025-06-01141290310.3390/cells14120903Unlocking Cellular Memory and Gene Regulatory Networks: Pioneering the Future of Therapeutic InnovationsMd Sorique Aziz Momin0Jhuma Bhadra1Debmalya Bhunia2Achinta Sannigrahi3Nayan De4School of Physics and Astronomy, College of Science, Rochester Institute of Technology, Rochester, NY 14623, USADepartment of Chemistry, Sarojini Naidu College for Women, Kolkata 700028, IndiaCold Spring Harbor Laboratory, 1 Bungtown Rd, Cold Spring Harbor, NY 11724, USADepartment of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USAInstitute for System Biology, 401 Terry Ave N, Seattle, WA 98109, USACellular memory is the competence of cells to preserve information from past experiences and respond aptly. This memory is maintained and controlled by gene regulatory networks (GRNs). GRNs are crucial for understanding why some cells are resistant to treatment, particularly for cancer. In our study, we created a new mathematical model to understand how “noise” affects cellular memory in GRNs, focusing on a “double positive feedback loop”. Our theoretical perspective article equipped with mathematical modeling exhibits how noise and feedback loops interact in GRNs. It also proposes a potential theoretical avenue for future therapy. By targeting the mechanisms that maintain drug resistance in cells, we aim to develop therapies that can restore the sensitivity of cancer cells to treatment.https://www.mdpi.com/2073-4409/14/12/903gene regulatory networkscellular memorynoiseinformation theorydrug resistance |
| spellingShingle | Md Sorique Aziz Momin Jhuma Bhadra Debmalya Bhunia Achinta Sannigrahi Nayan De Unlocking Cellular Memory and Gene Regulatory Networks: Pioneering the Future of Therapeutic Innovations Cells gene regulatory networks cellular memory noise information theory drug resistance |
| title | Unlocking Cellular Memory and Gene Regulatory Networks: Pioneering the Future of Therapeutic Innovations |
| title_full | Unlocking Cellular Memory and Gene Regulatory Networks: Pioneering the Future of Therapeutic Innovations |
| title_fullStr | Unlocking Cellular Memory and Gene Regulatory Networks: Pioneering the Future of Therapeutic Innovations |
| title_full_unstemmed | Unlocking Cellular Memory and Gene Regulatory Networks: Pioneering the Future of Therapeutic Innovations |
| title_short | Unlocking Cellular Memory and Gene Regulatory Networks: Pioneering the Future of Therapeutic Innovations |
| title_sort | unlocking cellular memory and gene regulatory networks pioneering the future of therapeutic innovations |
| topic | gene regulatory networks cellular memory noise information theory drug resistance |
| url | https://www.mdpi.com/2073-4409/14/12/903 |
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