Functional near⁃infrared spectroscopy of brain network functional connectivity in patients with post⁃stroke cognitive impairment
Objective To explore the similarities and differences of resting brain functional connectivity（FC）between patients with post-stroke cognitive impairment（PSCI）and healthy adults by functional near-infrared spectroscopy（fNIRS）.Methods A total of 40 PSCI patients hospitalized in the Rehabilitation Medi...
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| Format: | Article |
| Language: | zho |
| Published: |
The Editorial Department of Chinese Journal of Clinical Research
2025-06-01
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| Series: | Zhongguo linchuang yanjiu |
| Subjects: | |
| Online Access: | http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20250617 |
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| Summary: | Objective To explore the similarities and differences of resting brain functional connectivity（FC）between patients with post-stroke cognitive impairment（PSCI）and healthy adults by functional near-infrared spectroscopy（fNIRS）.Methods A total of 40 PSCI patients hospitalized in the Rehabilitation Medicine Department of Linyi People’s Hospital from July 2023 to August 2024 and 20 healthy adults recruited from society were prospectively and randomly selected.fNIRS was used to detect the hemodynamic data of resting frontal lobe，parietal lobe and occipital lobe for 5 min in 20PSCI patients with left hemisphere stroke（LHS group），20 PSCI patients with right hemisphere stroke（RHS group）and20 healthy controls（control group）. The differences of FC intensity among the three groups were compared in 14 regions of interest （ROI），including left and right dorsolateral prefrontal cortex （DLPFC），frontal pole，left and right orbitofrontal cortex（OFC），left and right Broca’s area，left and right primary sensory cortex（S1），left and right premotor cortex and supplementary motor area（PMC/SMA），left and right primary motor cortex（M1），and occipital cortex. Results The results of oxyhemoglobin - based analysis confirmed that compared with the control group（0.46±0.18），the average value of brain FC intensity decreased in LHS group（0.39±0.13）and RHS group（0.39±0.12），but the difference was not statistically significant（P>0.05）. The results of homologous ROI analysis suggested that the FC intensity of L - M1 in LHS group and R - DLPFC in RHS group were lower compared to the healthy control group significantly（P<0.05）. The results of non-homologous ROI analysis indicated that the FC intensity of R-M1-to-L-M1 andR-PMC/SMA-to-L-M1 in LHS group and RHS group were lower compared to the control group significantly（P< 0.05）.The FC intensity of R-Broca-to-L-Broca and R-S1-to-L-M1 in RHS group were lower than those in control group（P<0.05）. The FC intensity of R-PMC/SMA-to-L-PMC/SMA in LHS group was lower compared to control group significantly（P<0.05）. Conclusion The research on resting -state brain FC using fNIRS shows that the whole brain FC intensity in the stroke groups is lower than that in the control group，but without significant statistical difference. Intra-hemispheric and inter- hemispheric analyses show that the heterogeneity of FC intensity changes，and the decrease of FC intensity occur partially in M1，S1，PMC/SMA and Broca areas of LHS and RHS groups. |
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| ISSN: | 1674-8182 |