Validation of an automated cough detection algorithm for tracking recovery of pulmonary tuberculosis patients.
<h4>Background</h4>A laboratory-free test for assessing recovery from pulmonary tuberculosis (TB) would be extremely beneficial in regions of the world where laboratory facilities are lacking. Our hypothesis is that analysis of cough sound recordings may provide such a test. In the curre...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0046229&type=printable |
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| author | Sandra Larson Germán Comina Robert H Gilman Brian H Tracey Marjory Bravard José W López |
| author_facet | Sandra Larson Germán Comina Robert H Gilman Brian H Tracey Marjory Bravard José W López |
| author_sort | Sandra Larson |
| collection | DOAJ |
| description | <h4>Background</h4>A laboratory-free test for assessing recovery from pulmonary tuberculosis (TB) would be extremely beneficial in regions of the world where laboratory facilities are lacking. Our hypothesis is that analysis of cough sound recordings may provide such a test. In the current paper, we present validation of a cough analysis tool.<h4>Methodology/principal findings</h4>Cough data was collected from a cohort of TB patients in Lima, Peru and 25.5 hours of recordings were manually annotated by clinical staff. Analysis software was developed and validated by comparison to manual scoring. Because many patients cough in bursts, coughing was characterized in terms of cough epochs. Our software correctly detects 75.5% of cough episodes with a specificity of 99.6% (comparable to past results using the same definition) and a median false positive rate of 4 false positives/hour, due to the noisy, real-world nature of our dataset. We then manually review detected coughs to eliminate false positives, in effect using the algorithm as a pre-screening tool that reduces reviewing time to roughly 5% of the recording length. This cough analysis approach provides a foundation to support larger-scale studies of coughing rates over time for TB patients undergoing treatment. |
| format | Article |
| id | doaj-art-ce18fee40f8b414592bad01608ab05c2 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-ce18fee40f8b414592bad01608ab05c22025-08-20T02:30:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01710e4622910.1371/journal.pone.0046229Validation of an automated cough detection algorithm for tracking recovery of pulmonary tuberculosis patients.Sandra LarsonGermán CominaRobert H GilmanBrian H TraceyMarjory BravardJosé W López<h4>Background</h4>A laboratory-free test for assessing recovery from pulmonary tuberculosis (TB) would be extremely beneficial in regions of the world where laboratory facilities are lacking. Our hypothesis is that analysis of cough sound recordings may provide such a test. In the current paper, we present validation of a cough analysis tool.<h4>Methodology/principal findings</h4>Cough data was collected from a cohort of TB patients in Lima, Peru and 25.5 hours of recordings were manually annotated by clinical staff. Analysis software was developed and validated by comparison to manual scoring. Because many patients cough in bursts, coughing was characterized in terms of cough epochs. Our software correctly detects 75.5% of cough episodes with a specificity of 99.6% (comparable to past results using the same definition) and a median false positive rate of 4 false positives/hour, due to the noisy, real-world nature of our dataset. We then manually review detected coughs to eliminate false positives, in effect using the algorithm as a pre-screening tool that reduces reviewing time to roughly 5% of the recording length. This cough analysis approach provides a foundation to support larger-scale studies of coughing rates over time for TB patients undergoing treatment.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0046229&type=printable |
| spellingShingle | Sandra Larson Germán Comina Robert H Gilman Brian H Tracey Marjory Bravard José W López Validation of an automated cough detection algorithm for tracking recovery of pulmonary tuberculosis patients. PLoS ONE |
| title | Validation of an automated cough detection algorithm for tracking recovery of pulmonary tuberculosis patients. |
| title_full | Validation of an automated cough detection algorithm for tracking recovery of pulmonary tuberculosis patients. |
| title_fullStr | Validation of an automated cough detection algorithm for tracking recovery of pulmonary tuberculosis patients. |
| title_full_unstemmed | Validation of an automated cough detection algorithm for tracking recovery of pulmonary tuberculosis patients. |
| title_short | Validation of an automated cough detection algorithm for tracking recovery of pulmonary tuberculosis patients. |
| title_sort | validation of an automated cough detection algorithm for tracking recovery of pulmonary tuberculosis patients |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0046229&type=printable |
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