Association of inflammatory markers and endothelial dysfunction with depression in patients with ischemic cerebrovascular disease
<p><strong>Foundation:</strong> depression in ischemic cerebrovascular disease is one of the most frequent non-neurological complications.<br /><strong>Objective:</strong> to determine the association of inflammatory markers and endothelial dysfunction with depres...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Spanish |
| Published: |
Centro Provincial de Información de Ciencias Médicas. Cienfuegos
2023-10-01
|
| Series: | Medisur |
| Subjects: | |
| Online Access: | http://medisur.sld.cu/index.php/medisur/article/view/5780 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832576855154098176 |
|---|---|
| author | Julcileia Imara D De Carvalho Muenho Marisol Peña Sanchez Alina González-Quevedo Monteagudo Danay Martínez Puentes Sergio González García Marianela Arteche Prior Asdrubal Arias Morales |
| author_facet | Julcileia Imara D De Carvalho Muenho Marisol Peña Sanchez Alina González-Quevedo Monteagudo Danay Martínez Puentes Sergio González García Marianela Arteche Prior Asdrubal Arias Morales |
| author_sort | Julcileia Imara D De Carvalho Muenho |
| collection | DOAJ |
| description | <p><strong>Foundation:</strong> depression in ischemic cerebrovascular disease is one of the most frequent non-neurological complications.<br /><strong>Objective:</strong> to determine the association of inflammatory markers and endothelial dysfunction with depression in patients with ischemic cerebrovascular disease.<br /><strong>Methods:</strong> an analytical, prospective, cross-sectional study was carried out in patients with acute (N=22) and non-acute (N=37) ischemic cerebrovascular disease; treated at the Institute of Neurology and Neurosurgery; and the Manuel Fajardo Hospital, in Havana, Cuba. Demographic variables, risk factors, etiology and location of the infarction, neurological deficiency, disability for activities of daily living (Barthel index), neuropsychological (depression by Beck inventory and Hamilton test) were collected. C-reactive protein, alpha-1-antitrypsin, C3 and C4 complements, and microalbuminuria were determined.<br /><strong>Results:</strong> the scores of the neuropsychological tests did not have significant differences between the acute and non-acute phase, but there was a statistical increase in the frequency of patients without depression and with slight depression in the non-acute phase. In the acute phase, C4, and in the non-acute phase, C3, C-reactive protein and alpha-1-antitrypsin were directly correlated with the Beck inventory score. C-reactive protein and C3 were statistically correlated with the Hamilton test score. In the multivariate analysis, C-reactive protein showed an independent association with the degree of depression by the Hamilton test.<br /><strong>Conclusions:</strong> C-reactive protein could be related to the severity of depression, perhaps by association with the disability for activities of daily living.</p> |
| format | Article |
| id | doaj-art-ce1439b065574908b4f3a74bdb5c364c |
| institution | Kabale University |
| issn | 1727-897X |
| language | Spanish |
| publishDate | 2023-10-01 |
| publisher | Centro Provincial de Información de Ciencias Médicas. Cienfuegos |
| record_format | Article |
| series | Medisur |
| spelling | doaj-art-ce1439b065574908b4f3a74bdb5c364c2025-01-30T21:29:01ZspaCentro Provincial de Información de Ciencias Médicas. CienfuegosMedisur1727-897X2023-10-01215101410232388Association of inflammatory markers and endothelial dysfunction with depression in patients with ischemic cerebrovascular diseaseJulcileia Imara D De Carvalho Muenho0Marisol Peña Sanchez1Alina González-Quevedo Monteagudo2Danay Martínez Puentes3Sergio González García4Marianela Arteche Prior5Asdrubal Arias Morales6Hospital Central Dr. Antonio Aghostino Neto. Lubango, Angola.Instituto de Neurologia y Neurocirugía. La Habana.Cuba.Instituto de Neurología y Neurocirugía. La Habana, Cuba.Instituto de Neurología y Neurocirugía. La Habana, Cuba.Facultad de Medicina Dr. Miguel Enríquez.. La Habana, Cuba.Instituto de Neurología y Neurocirugía. La Habana, Cuba.Hospital Clínico-Universitario Comandante Manuel Fajardo. La Habana, Cuba.<p><strong>Foundation:</strong> depression in ischemic cerebrovascular disease is one of the most frequent non-neurological complications.<br /><strong>Objective:</strong> to determine the association of inflammatory markers and endothelial dysfunction with depression in patients with ischemic cerebrovascular disease.<br /><strong>Methods:</strong> an analytical, prospective, cross-sectional study was carried out in patients with acute (N=22) and non-acute (N=37) ischemic cerebrovascular disease; treated at the Institute of Neurology and Neurosurgery; and the Manuel Fajardo Hospital, in Havana, Cuba. Demographic variables, risk factors, etiology and location of the infarction, neurological deficiency, disability for activities of daily living (Barthel index), neuropsychological (depression by Beck inventory and Hamilton test) were collected. C-reactive protein, alpha-1-antitrypsin, C3 and C4 complements, and microalbuminuria were determined.<br /><strong>Results:</strong> the scores of the neuropsychological tests did not have significant differences between the acute and non-acute phase, but there was a statistical increase in the frequency of patients without depression and with slight depression in the non-acute phase. In the acute phase, C4, and in the non-acute phase, C3, C-reactive protein and alpha-1-antitrypsin were directly correlated with the Beck inventory score. C-reactive protein and C3 were statistically correlated with the Hamilton test score. In the multivariate analysis, C-reactive protein showed an independent association with the degree of depression by the Hamilton test.<br /><strong>Conclusions:</strong> C-reactive protein could be related to the severity of depression, perhaps by association with the disability for activities of daily living.</p>http://medisur.sld.cu/index.php/medisur/article/view/5780accidente cerebrovascular isquémicodepresiónproteína c reactivareacción en cadena de la polimerasabiomarcadores |
| spellingShingle | Julcileia Imara D De Carvalho Muenho Marisol Peña Sanchez Alina González-Quevedo Monteagudo Danay Martínez Puentes Sergio González García Marianela Arteche Prior Asdrubal Arias Morales Association of inflammatory markers and endothelial dysfunction with depression in patients with ischemic cerebrovascular disease Medisur accidente cerebrovascular isquémico depresión proteína c reactiva reacción en cadena de la polimerasa biomarcadores |
| title | Association of inflammatory markers and endothelial dysfunction with depression in patients with ischemic cerebrovascular disease |
| title_full | Association of inflammatory markers and endothelial dysfunction with depression in patients with ischemic cerebrovascular disease |
| title_fullStr | Association of inflammatory markers and endothelial dysfunction with depression in patients with ischemic cerebrovascular disease |
| title_full_unstemmed | Association of inflammatory markers and endothelial dysfunction with depression in patients with ischemic cerebrovascular disease |
| title_short | Association of inflammatory markers and endothelial dysfunction with depression in patients with ischemic cerebrovascular disease |
| title_sort | association of inflammatory markers and endothelial dysfunction with depression in patients with ischemic cerebrovascular disease |
| topic | accidente cerebrovascular isquémico depresión proteína c reactiva reacción en cadena de la polimerasa biomarcadores |
| url | http://medisur.sld.cu/index.php/medisur/article/view/5780 |
| work_keys_str_mv | AT julcileiaimaraddecarvalhomuenho associationofinflammatorymarkersandendothelialdysfunctionwithdepressioninpatientswithischemiccerebrovasculardisease AT marisolpenasanchez associationofinflammatorymarkersandendothelialdysfunctionwithdepressioninpatientswithischemiccerebrovasculardisease AT alinagonzalezquevedomonteagudo associationofinflammatorymarkersandendothelialdysfunctionwithdepressioninpatientswithischemiccerebrovasculardisease AT danaymartinezpuentes associationofinflammatorymarkersandendothelialdysfunctionwithdepressioninpatientswithischemiccerebrovasculardisease AT sergiogonzalezgarcia associationofinflammatorymarkersandendothelialdysfunctionwithdepressioninpatientswithischemiccerebrovasculardisease AT marianelaartecheprior associationofinflammatorymarkersandendothelialdysfunctionwithdepressioninpatientswithischemiccerebrovasculardisease AT asdrubalariasmorales associationofinflammatorymarkersandendothelialdysfunctionwithdepressioninpatientswithischemiccerebrovasculardisease |