NAD+-dependent Sirt6 is a key regulator involved in telomere shortening of in vitro-cultured preimplantation embryos

NAD+-dependent Sirt6 is a key regulator involved in telomere shortening of in vitro-cultured preimplantation embryos

Abstract Telomere length (TL) is important for maintaining the individual health of a species. Recent studies shows that in vitro fertilization therapy can drastically reduce TL in offspring, however, the underlying molecular mechanism remains unknown. Sirt6 is a NAD+-dependent epigenetic regulator...

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Main Authors: Danjun Li, Wenzhi Li, Xiaoyu Liao, Shutian Jiang, Meng Ma, Zhijie Hu, Kaibo Lin, Weina Yu, Xue Sun, Yong Fan, Haibo Wu, Mingru Yin, Li Wang, Lun Suo, Hui Long, Xuefeng Lu, Yanping Kuang, Qifeng Lyu
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08567-x
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