Cardiotoxicity in Children With Acute Ieukemia Treated by Anthracycline; Detected by Cardiac Troponins and Echcocardiography
Background and objectives:the use of anthracycline antineoplastic agents has conducted to improved pediatric malignancies’ outcomes, yet their use is limited by their potential cardiotoxic effects. Thus, children who have received anthracyclines require cardiac evaluation periodically. The serum le...
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Kurdistan Higher Council Of Medical Specialties
2023-04-01
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| Series: | Advanced Medical Journal |
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| Online Access: | https://amj.khcms.edu.krd/index.php/main/article/view/170 |
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| author | Yaran Abbas Abdulqader Mouroge Hashim Al-Ani Nadine Abdulrazzak Mahmood |
| author_facet | Yaran Abbas Abdulqader Mouroge Hashim Al-Ani Nadine Abdulrazzak Mahmood |
| author_sort | Yaran Abbas Abdulqader |
| collection | DOAJ |
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Background and objectives:the use of anthracycline antineoplastic agents has conducted to improved pediatric malignancies’ outcomes, yet their use is limited by their potential cardiotoxic effects. Thus, children who have received anthracyclines require cardiac evaluation periodically. The serum levels of cardiac troponins have been shown to be elevated in response to severity of cardiac dysfunction. The aim of our study was to investigate the role of serum levels of cardiac troponin and echocardiography as sensitive markers for anthracycline-induced cardiotoxicity in children with malignancy.
Methods:we carried out this study at Nanakali Hospital, Pediatric Hematology and Oncology unit. We measured plasma high sensitive cardiac troponin T in 24 patients who received anthracyclines for their malignancy at cumulative doses of 75-310mg/m2, between Feb 2017 and Feb 2018. Evaluation of the patients for cardiac functions included physical examination, chest X-ray and echocardiography in addition to cardiac troponins.
Results: Of the 24 patients, 3 (12.5%) had abnormal cardiac functions by echocardiography. Serum troponin level in two of them was significantly elevated. Physical findings of the patients were significant. Chest X-ray in 2 (8.3%) showed radiological findings.
Conclusions: Serum troponin concentration and Echocardiography may be practical and sensitive indicator of abnormal cardiac function in children receiving anthracycline therapy.
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| format | Article |
| id | doaj-art-ce0ed9eb1d7a49b99e0af3d7bf5dcbb3 |
| institution | OA Journals |
| issn | 2958-8979 2957-3580 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Kurdistan Higher Council Of Medical Specialties |
| record_format | Article |
| series | Advanced Medical Journal |
| spelling | doaj-art-ce0ed9eb1d7a49b99e0af3d7bf5dcbb32025-08-20T02:27:29ZengKurdistan Higher Council Of Medical SpecialtiesAdvanced Medical Journal2958-89792957-35802023-04-014210.56056/amj.2018.61171Cardiotoxicity in Children With Acute Ieukemia Treated by Anthracycline; Detected by Cardiac Troponins and EchcocardiographyYaran Abbas Abdulqader 0Mouroge Hashim Al-Ani1Nadine Abdulrazzak Mahmood2M. B. Ch. B, Board candidate of pediatricsM. B. Ch. B/ C.A.B.P. Professor of pediatrics, at Hawler Medical UniversityM. B. Ch. B/C.A.B.P/D.Ch (Pediatric cardiology), Hawler Medical University Background and objectives:the use of anthracycline antineoplastic agents has conducted to improved pediatric malignancies’ outcomes, yet their use is limited by their potential cardiotoxic effects. Thus, children who have received anthracyclines require cardiac evaluation periodically. The serum levels of cardiac troponins have been shown to be elevated in response to severity of cardiac dysfunction. The aim of our study was to investigate the role of serum levels of cardiac troponin and echocardiography as sensitive markers for anthracycline-induced cardiotoxicity in children with malignancy. Methods:we carried out this study at Nanakali Hospital, Pediatric Hematology and Oncology unit. We measured plasma high sensitive cardiac troponin T in 24 patients who received anthracyclines for their malignancy at cumulative doses of 75-310mg/m2, between Feb 2017 and Feb 2018. Evaluation of the patients for cardiac functions included physical examination, chest X-ray and echocardiography in addition to cardiac troponins. Results: Of the 24 patients, 3 (12.5%) had abnormal cardiac functions by echocardiography. Serum troponin level in two of them was significantly elevated. Physical findings of the patients were significant. Chest X-ray in 2 (8.3%) showed radiological findings. Conclusions: Serum troponin concentration and Echocardiography may be practical and sensitive indicator of abnormal cardiac function in children receiving anthracycline therapy. https://amj.khcms.edu.krd/index.php/main/article/view/170Acute LeukemiaCardiac TroponinsCardiotoxicity |
| spellingShingle | Yaran Abbas Abdulqader Mouroge Hashim Al-Ani Nadine Abdulrazzak Mahmood Cardiotoxicity in Children With Acute Ieukemia Treated by Anthracycline; Detected by Cardiac Troponins and Echcocardiography Advanced Medical Journal Acute Leukemia Cardiac Troponins Cardiotoxicity |
| title | Cardiotoxicity in Children With Acute Ieukemia Treated by Anthracycline; Detected by Cardiac Troponins and Echcocardiography |
| title_full | Cardiotoxicity in Children With Acute Ieukemia Treated by Anthracycline; Detected by Cardiac Troponins and Echcocardiography |
| title_fullStr | Cardiotoxicity in Children With Acute Ieukemia Treated by Anthracycline; Detected by Cardiac Troponins and Echcocardiography |
| title_full_unstemmed | Cardiotoxicity in Children With Acute Ieukemia Treated by Anthracycline; Detected by Cardiac Troponins and Echcocardiography |
| title_short | Cardiotoxicity in Children With Acute Ieukemia Treated by Anthracycline; Detected by Cardiac Troponins and Echcocardiography |
| title_sort | cardiotoxicity in children with acute ieukemia treated by anthracycline detected by cardiac troponins and echcocardiography |
| topic | Acute Leukemia Cardiac Troponins Cardiotoxicity |
| url | https://amj.khcms.edu.krd/index.php/main/article/view/170 |
| work_keys_str_mv | AT yaranabbasabdulqader cardiotoxicityinchildrenwithacuteieukemiatreatedbyanthracyclinedetectedbycardiactroponinsandechcocardiography AT mourogehashimalani cardiotoxicityinchildrenwithacuteieukemiatreatedbyanthracyclinedetectedbycardiactroponinsandechcocardiography AT nadineabdulrazzakmahmood cardiotoxicityinchildrenwithacuteieukemiatreatedbyanthracyclinedetectedbycardiactroponinsandechcocardiography |