SND Rs1799889(-) In The Promotor Of The Plasminogen Activator Inhibitor-1 Gene Contributes To The Risk Of DVT In Women
The incidence of deep venous thrombosis (DVT) depends on the specific genotype, inheritance of prothrombotic polymorphisms and the influence of environmental risk factors. Rs1799889(-) polymorphism in the promotor of PAI-1 gene has been described as a risk factor for hypercoagulable state. Objective...
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Medical University - Pleven
2015-12-01
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| Series: | Journal of Biomedical & Clinical Research |
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| Online Access: | https://jbcr.arphahub.com/article/34392/download/pdf/ |
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| author | Regina Komsa-Penkova Georgi Golemanov Boris Cankov Lubomir Beshev Petar Ivanov Pencho Tonchev |
| author_facet | Regina Komsa-Penkova Georgi Golemanov Boris Cankov Lubomir Beshev Petar Ivanov Pencho Tonchev |
| author_sort | Regina Komsa-Penkova |
| collection | DOAJ |
| description | The incidence of deep venous thrombosis (DVT) depends on the specific genotype, inheritance of prothrombotic polymorphisms and the influence of environmental risk factors. Rs1799889(-) polymorphism in the promotor of PAI-1 gene has been described as a risk factor for hypercoagulable state. Objective: To evaluate the contribution of thrombophilic rs1799889 (-) in the promotor of PAI-1 gene on the incidence of DVT in women and men in groups below and above 45 years of age. Тhere was significantly higher rs1799889 (-) polymorphism carriage among female patients with DVT vs controls (Chi squared =5.506, OR=2.170, p=0.021) but not in male patients (Chi squared =0.090 OR=1.147, p=0.825). A significant contribution of rs1799889 (-) polymorphism to early onset of the disease was found in female patients aged 45+ and carriers of the polymorphism (Chi squared =7.476, p=0.006), but not in young women. |
| format | Article |
| id | doaj-art-ce0af2d2ca874e109e4ebc965c40c172 |
| institution | DOAJ |
| issn | 1313-9053 |
| language | English |
| publishDate | 2015-12-01 |
| publisher | Medical University - Pleven |
| record_format | Article |
| series | Journal of Biomedical & Clinical Research |
| spelling | doaj-art-ce0af2d2ca874e109e4ebc965c40c1722025-08-20T02:48:05ZengMedical University - PlevenJournal of Biomedical & Clinical Research1313-90532015-12-018212413210.1515/jbcr-2015-016234392SND Rs1799889(-) In The Promotor Of The Plasminogen Activator Inhibitor-1 Gene Contributes To The Risk Of DVT In WomenRegina Komsa-PenkovaGeorgi GolemanovBoris CankovLubomir BeshevPetar IvanovPencho TonchevThe incidence of deep venous thrombosis (DVT) depends on the specific genotype, inheritance of prothrombotic polymorphisms and the influence of environmental risk factors. Rs1799889(-) polymorphism in the promotor of PAI-1 gene has been described as a risk factor for hypercoagulable state. Objective: To evaluate the contribution of thrombophilic rs1799889 (-) in the promotor of PAI-1 gene on the incidence of DVT in women and men in groups below and above 45 years of age. Тhere was significantly higher rs1799889 (-) polymorphism carriage among female patients with DVT vs controls (Chi squared =5.506, OR=2.170, p=0.021) but not in male patients (Chi squared =0.090 OR=1.147, p=0.825). A significant contribution of rs1799889 (-) polymorphism to early onset of the disease was found in female patients aged 45+ and carriers of the polymorphism (Chi squared =7.476, p=0.006), but not in young women.https://jbcr.arphahub.com/article/34392/download/pdf/deep venous thrombosisthrombophiliaRs1799889(- |
| spellingShingle | Regina Komsa-Penkova Georgi Golemanov Boris Cankov Lubomir Beshev Petar Ivanov Pencho Tonchev SND Rs1799889(-) In The Promotor Of The Plasminogen Activator Inhibitor-1 Gene Contributes To The Risk Of DVT In Women Journal of Biomedical & Clinical Research deep venous thrombosis thrombophilia Rs1799889(- |
| title | SND Rs1799889(-) In The Promotor Of The Plasminogen Activator Inhibitor-1 Gene Contributes To The Risk Of DVT In Women |
| title_full | SND Rs1799889(-) In The Promotor Of The Plasminogen Activator Inhibitor-1 Gene Contributes To The Risk Of DVT In Women |
| title_fullStr | SND Rs1799889(-) In The Promotor Of The Plasminogen Activator Inhibitor-1 Gene Contributes To The Risk Of DVT In Women |
| title_full_unstemmed | SND Rs1799889(-) In The Promotor Of The Plasminogen Activator Inhibitor-1 Gene Contributes To The Risk Of DVT In Women |
| title_short | SND Rs1799889(-) In The Promotor Of The Plasminogen Activator Inhibitor-1 Gene Contributes To The Risk Of DVT In Women |
| title_sort | snd rs1799889 in the promotor of the plasminogen activator inhibitor 1 gene contributes to the risk of dvt in women |
| topic | deep venous thrombosis thrombophilia Rs1799889(- |
| url | https://jbcr.arphahub.com/article/34392/download/pdf/ |
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