ST11 carbapenem-resistant Klebsiella pneumoniae integrates virulence plasmid fragments into the chromosome via insertion sequence

ST11 carbapenem-resistant Klebsiella pneumoniae integrates virulence plasmid fragments into the chromosome via insertion sequence

Abstract Virulence plasmids are key drivers of hypervirulence in Klebsiella pneumoniae. Here, we report a systematic analysis of chromosomal integration of a p17-15vir-derived fragment carrying virulence (rmpA2 and iutA-iucABCD) and resistance genes in nine bla KPC−2-positive ST11-KL47 carbapenem-re...

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Bibliographic Details
Main Authors: Xu Liu, Lijuan Xu, Huiyue Dong, Shangshang Qin, Yan Li, Hong Yao
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Microbiology
Subjects:
Carbapenem-resistant Klebsiella pneumonia
Insertion sequence
Virulence plasmids
Integration mechanisms
Online Access:https://doi.org/10.1186/s12866-025-04235-6
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