Higher risk of recurrence in early-stage breast cancer patients with increased levels of ribosomal protein S6

Higher risk of recurrence in early-stage breast cancer patients with increased levels of ribosomal protein S6

Abstract PI3K/AKT/mTOR pathway is implicated in breast cancer progression and recurrence. The identification of PIK3CA and AKT1 mutations and loss of PTEN serve as selection criterion for targeted therapies involving selective inhibitors. However, they do not consistently align with pathway activati...

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Bibliographic Details
Main Authors: Florencia Cascardo, Micaela Vivanco, María Cecilia Perrone, Andrea Werbach, Diego Enrico, Pablo Mando, Mora Amat, Paula Martínez-Vazquez, Javier Burruchaga, María Mac Donnell, Claudia Lanari, Ariel Zwenger, Federico Waisberg, Virginia Novaro
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
Breast cancer
Prognostic markers
PI3K/AKT/mTOR pathway
Predictive markers
Tumor relapse
Immunohistochemistry analysis
Online Access:https://doi.org/10.1038/s41598-024-75154-1
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