The Current and Future Therapies of Bone Regeneration to Repair Bone Defects
Bone defects often result from tumor resection, congenital malformation, trauma, fractures, surgery, or periodontitis in dentistry. Although dental implants serve as an effective treatment to recover mouth function from tooth defects, many patients do not have the adequate bone volume to build an im...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2012/148261 |
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| author | Eijiro Jimi Shizu Hirata Kenji Osawa Masamichi Terashita Chiaki Kitamura Hidefumi Fukushima |
| author_facet | Eijiro Jimi Shizu Hirata Kenji Osawa Masamichi Terashita Chiaki Kitamura Hidefumi Fukushima |
| author_sort | Eijiro Jimi |
| collection | DOAJ |
| description | Bone defects often result from tumor resection, congenital malformation, trauma, fractures, surgery, or periodontitis in dentistry. Although dental implants serve as an effective treatment to recover mouth function from tooth defects, many patients do not have the adequate bone volume to build an implant. The gold standard for the reconstruction of large bone defects is the use of autogenous bone grafts. While autogenous bone graft is the most effective clinical method, surgical stress to the part of the bone being extracted and the quantity of extractable bone limit this method. Recently mesenchymal stem cell-based therapies have the potential to provide an effective treatment of osseous defects. In this paper, we discuss both the current therapy for bone regeneration and the perspectives in the field of stem cell-based regenerative medicine, addressing the sources of stem cells and growth factors used to induce bone regeneration effectively and reproducibly. |
| format | Article |
| id | doaj-art-ce05c90567894fbfb42d7f8d384cece1 |
| institution | DOAJ |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-ce05c90567894fbfb42d7f8d384cece12025-08-20T03:19:41ZengWileyInternational Journal of Dentistry1687-87281687-87362012-01-01201210.1155/2012/148261148261The Current and Future Therapies of Bone Regeneration to Repair Bone DefectsEijiro Jimi0Shizu Hirata1Kenji Osawa2Masamichi Terashita3Chiaki Kitamura4Hidefumi Fukushima5Division of Molecular Signaling and Biochemistry, Department of Biosciences, Kyushu Dental College, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu, Fukuoka 803-8580, JapanDepartment of Cardiology and Periodontology, Kyushu Dental College, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu, Fukuoka 803-8580, JapanDivision of Molecular Signaling and Biochemistry, Department of Biosciences, Kyushu Dental College, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu, Fukuoka 803-8580, JapanDepartment of Clinical Communication Practice, Kyushu Dental College, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu, Fukuoka 803-8580, JapanCenter for Oral Biological Research, Kyushu Dental College, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu, Fukuoka 803-8580, JapanDivision of Molecular Signaling and Biochemistry, Department of Biosciences, Kyushu Dental College, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu, Fukuoka 803-8580, JapanBone defects often result from tumor resection, congenital malformation, trauma, fractures, surgery, or periodontitis in dentistry. Although dental implants serve as an effective treatment to recover mouth function from tooth defects, many patients do not have the adequate bone volume to build an implant. The gold standard for the reconstruction of large bone defects is the use of autogenous bone grafts. While autogenous bone graft is the most effective clinical method, surgical stress to the part of the bone being extracted and the quantity of extractable bone limit this method. Recently mesenchymal stem cell-based therapies have the potential to provide an effective treatment of osseous defects. In this paper, we discuss both the current therapy for bone regeneration and the perspectives in the field of stem cell-based regenerative medicine, addressing the sources of stem cells and growth factors used to induce bone regeneration effectively and reproducibly.http://dx.doi.org/10.1155/2012/148261 |
| spellingShingle | Eijiro Jimi Shizu Hirata Kenji Osawa Masamichi Terashita Chiaki Kitamura Hidefumi Fukushima The Current and Future Therapies of Bone Regeneration to Repair Bone Defects International Journal of Dentistry |
| title | The Current and Future Therapies of Bone Regeneration to Repair Bone Defects |
| title_full | The Current and Future Therapies of Bone Regeneration to Repair Bone Defects |
| title_fullStr | The Current and Future Therapies of Bone Regeneration to Repair Bone Defects |
| title_full_unstemmed | The Current and Future Therapies of Bone Regeneration to Repair Bone Defects |
| title_short | The Current and Future Therapies of Bone Regeneration to Repair Bone Defects |
| title_sort | current and future therapies of bone regeneration to repair bone defects |
| url | http://dx.doi.org/10.1155/2012/148261 |
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