Structural basis for the transport and regulation mechanism of the multidrug resistance-associated protein 2

Structural basis for the transport and regulation mechanism of the multidrug resistance-associated protein 2

Abstract Multidrug resistance-associated protein 2 (MRP2) is an ATP-powered exporter important for maintaining liver homeostasis and a potential contributor to chemotherapeutic resistance. Using cryogenic electron microscopy (cryo-EM), we determine the structures of human MRP2 in three conformationa...

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Bibliographic Details
Main Authors: Eriko Koide, Harlan L. Pietz, Jean Beltran, Jue Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55810-w
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