Corrigendum to “Preclinical evaluation of the safety and effectiveness of a new bioartificial cornea” [Bioact. Mater. 2023 (8) 29 265–278]
Cross-linking agents are frequently used to restore corneal properties after decellularization, and it is especially important to select an appropriate method to avoid excessive cross-linking. In addition, how to promote wound healing and how to improve scar formation require further investigation....
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| Language: | English |
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KeAi Communications Co., Ltd.
2025-11-01
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| Series: | Bioactive Materials |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X25003044 |
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| author | Yansha Hao Jingting Zhou Ju Tan Feng Xiang Zhongliang Qin Jun Yao Gang Li Mingcan Yang Lingqin Zeng Wen Zeng Chuhong Zhu |
| author_facet | Yansha Hao Jingting Zhou Ju Tan Feng Xiang Zhongliang Qin Jun Yao Gang Li Mingcan Yang Lingqin Zeng Wen Zeng Chuhong Zhu |
| author_sort | Yansha Hao |
| collection | DOAJ |
| description | Cross-linking agents are frequently used to restore corneal properties after decellularization, and it is especially important to select an appropriate method to avoid excessive cross-linking. In addition, how to promote wound healing and how to improve scar formation require further investigation. To ensure the safety and efficacy of animal-derived products, we designed bioartificial corneas (BACs) according to the criteria for Class III medical devices. Our BACs do not require cross-linking agents and increase mechanical strength via self-cross-linking of aldehyde-modified hyaluronic acid (AHA) and carboxymethyl chitosan (CMC) on the surface of decellularized porcine corneas (DPCs). The results showed that the BACs had good biocompatibility and transparency, and the modification enhanced their antibacterial and anti-inflammatory properties in vitro. Preclinical animal studies showed that the BACs can rapidly regenerate the epithelium and restore vision within a month. After 3 months, the BACs were gradually filled with epithelial, stromal, and neuronal cells, and after 6 months, their transparency and histology were almost normal. In addition, side effects such as corneal neovascularization, conjunctival hyperemia, and ciliary body hyperemia rarely occur in vivo. Therefore, these BACs show promise for clinical application for the treatment of infectious corneal ulcers and as a temporary covering for corneal perforations to achieve the more time. |
| format | Article |
| id | doaj-art-ce0309bf36f64422bcfee4bce5ae8ba5 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-11-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-ce0309bf36f64422bcfee4bce5ae8ba52025-08-20T03:58:00ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-11-015370470510.1016/j.bioactmat.2025.07.011Corrigendum to “Preclinical evaluation of the safety and effectiveness of a new bioartificial cornea” [Bioact. Mater. 2023 (8) 29 265–278]Yansha Hao0Jingting Zhou1Ju Tan2Feng Xiang3Zhongliang Qin4Jun Yao5Gang Li6Mingcan Yang7Lingqin Zeng8Wen Zeng9Chuhong Zhu10Department of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; State Key Laboratory of Trauma, Burnand Combined Injury, Chongqing, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; State Key Laboratory of Trauma, Burnand Combined Injury, Chongqing, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; State Key Laboratory of Trauma, Burnand Combined Injury, Chongqing, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; State Key Laboratory of Trauma, Burnand Combined Injury, Chongqing, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; State Key Laboratory of Trauma, Burnand Combined Injury, Chongqing, China; Zhong Zhi Yi Gu Research Institute, Chongqing Jiukang Medical Research Institute Co., Ltd., ChinaHong Chang Biotechnology Co., Ltd, Guangzhou, 510700, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; State Key Laboratory of Trauma, Burnand Combined Injury, Chongqing, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; State Key Laboratory of Trauma, Burnand Combined Injury, Chongqing, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; State Key Laboratory of Trauma, Burnand Combined Injury, Chongqing, ChinaDepartment of Cell Biology, Third Military Army Medical University, Chongqing, 400038, China; Corresponding author. Department of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China.Department of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; State Key Laboratory of Trauma, Burnand Combined Injury, Chongqing, China; Corresponding author. Department of Cell Biology, Third Military Army Medical University, Chongqing, 400038, China.Cross-linking agents are frequently used to restore corneal properties after decellularization, and it is especially important to select an appropriate method to avoid excessive cross-linking. In addition, how to promote wound healing and how to improve scar formation require further investigation. To ensure the safety and efficacy of animal-derived products, we designed bioartificial corneas (BACs) according to the criteria for Class III medical devices. Our BACs do not require cross-linking agents and increase mechanical strength via self-cross-linking of aldehyde-modified hyaluronic acid (AHA) and carboxymethyl chitosan (CMC) on the surface of decellularized porcine corneas (DPCs). The results showed that the BACs had good biocompatibility and transparency, and the modification enhanced their antibacterial and anti-inflammatory properties in vitro. Preclinical animal studies showed that the BACs can rapidly regenerate the epithelium and restore vision within a month. After 3 months, the BACs were gradually filled with epithelial, stromal, and neuronal cells, and after 6 months, their transparency and histology were almost normal. In addition, side effects such as corneal neovascularization, conjunctival hyperemia, and ciliary body hyperemia rarely occur in vivo. Therefore, these BACs show promise for clinical application for the treatment of infectious corneal ulcers and as a temporary covering for corneal perforations to achieve the more time.http://www.sciencedirect.com/science/article/pii/S2452199X25003044 |
| spellingShingle | Yansha Hao Jingting Zhou Ju Tan Feng Xiang Zhongliang Qin Jun Yao Gang Li Mingcan Yang Lingqin Zeng Wen Zeng Chuhong Zhu Corrigendum to “Preclinical evaluation of the safety and effectiveness of a new bioartificial cornea” [Bioact. Mater. 2023 (8) 29 265–278] Bioactive Materials |
| title | Corrigendum to “Preclinical evaluation of the safety and effectiveness of a new bioartificial cornea” [Bioact. Mater. 2023 (8) 29 265–278] |
| title_full | Corrigendum to “Preclinical evaluation of the safety and effectiveness of a new bioartificial cornea” [Bioact. Mater. 2023 (8) 29 265–278] |
| title_fullStr | Corrigendum to “Preclinical evaluation of the safety and effectiveness of a new bioartificial cornea” [Bioact. Mater. 2023 (8) 29 265–278] |
| title_full_unstemmed | Corrigendum to “Preclinical evaluation of the safety and effectiveness of a new bioartificial cornea” [Bioact. Mater. 2023 (8) 29 265–278] |
| title_short | Corrigendum to “Preclinical evaluation of the safety and effectiveness of a new bioartificial cornea” [Bioact. Mater. 2023 (8) 29 265–278] |
| title_sort | corrigendum to preclinical evaluation of the safety and effectiveness of a new bioartificial cornea bioact mater 2023 8 29 265 278 |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X25003044 |
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