High Level of Resistance to nalidixic acid in Salmonella enterica serovar Typhi in Central India
Background: Fluoroquinolones are the drugs of choice for the treatment of typhoid fever. But the recent increase in minimum inhibitory concentration (MIC) values of ciprofloxacin in Salmonella Typhi may result in delayed response and serious complications. Nalidixic acid resistance has been used as...
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| Format: | Article |
| Language: | English |
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The Journal of Infection in Developing Countries
2009-07-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/419 |
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| author | Yashwant Kumar Anshu Sharma Kavaratty Raju Mani |
| author_facet | Yashwant Kumar Anshu Sharma Kavaratty Raju Mani |
| author_sort | Yashwant Kumar |
| collection | DOAJ |
| description | Background: Fluoroquinolones are the drugs of choice for the treatment of typhoid fever. But the recent increase in minimum inhibitory concentration (MIC) values of ciprofloxacin in Salmonella Typhi may result in delayed response and serious complications. Nalidixic acid resistance has been used as an indirect evidence of increased minimum inhibitory concentration for ciprofloxacin in Salmonella Typhi.
Methods: We evaluated the isolates received at the National Salmonella and Escherichia Centre for nalidixic acid and ciprofloxacin susceptibility using standard methods. Minimum inhibitory concentrations have also been evaluated.
Results: Ninety-six percent of the isolates were found to be nalidixic acid resistant while all isolates were found to be ciprofloxacin sensitive. The difference between minimum inhibitory concentration values of ciprofloxacin for nalidixic acid resistant and nalidixic acid sensitive isolates was found to be statistically significant.
Conclusion: The study may be helpful in revising treatment strategies for the infections caused by nalidixic acid resistant Salmonella Typhi in the country. |
| format | Article |
| id | doaj-art-ce00a9d2aa544546a7df49cec6eba355 |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2009-07-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-ce00a9d2aa544546a7df49cec6eba3552025-08-20T03:48:58ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802009-07-0130610.3855/jidc.419High Level of Resistance to nalidixic acid in Salmonella enterica serovar Typhi in Central IndiaYashwant Kumar0Anshu Sharma1Kavaratty Raju Mani2National Salmonella and Escherichia Centre, Central Research Institute, Kasauli 173204, Himachal PradeshNational Salmonella and Escherichia Centre, Central Research Institute, Kasauli 173204, Himachal PradeshNational Salmonella and Escherichia Centre, Central Research Institute, Kasauli 173204, Himachal PradeshBackground: Fluoroquinolones are the drugs of choice for the treatment of typhoid fever. But the recent increase in minimum inhibitory concentration (MIC) values of ciprofloxacin in Salmonella Typhi may result in delayed response and serious complications. Nalidixic acid resistance has been used as an indirect evidence of increased minimum inhibitory concentration for ciprofloxacin in Salmonella Typhi. Methods: We evaluated the isolates received at the National Salmonella and Escherichia Centre for nalidixic acid and ciprofloxacin susceptibility using standard methods. Minimum inhibitory concentrations have also been evaluated. Results: Ninety-six percent of the isolates were found to be nalidixic acid resistant while all isolates were found to be ciprofloxacin sensitive. The difference between minimum inhibitory concentration values of ciprofloxacin for nalidixic acid resistant and nalidixic acid sensitive isolates was found to be statistically significant. Conclusion: The study may be helpful in revising treatment strategies for the infections caused by nalidixic acid resistant Salmonella Typhi in the country.https://jidc.org/index.php/journal/article/view/419nalidixic acidresistanceSalmonella TyphiIndia |
| spellingShingle | Yashwant Kumar Anshu Sharma Kavaratty Raju Mani High Level of Resistance to nalidixic acid in Salmonella enterica serovar Typhi in Central India Journal of Infection in Developing Countries nalidixic acid resistance Salmonella Typhi India |
| title | High Level of Resistance to nalidixic acid in Salmonella enterica serovar Typhi in Central India |
| title_full | High Level of Resistance to nalidixic acid in Salmonella enterica serovar Typhi in Central India |
| title_fullStr | High Level of Resistance to nalidixic acid in Salmonella enterica serovar Typhi in Central India |
| title_full_unstemmed | High Level of Resistance to nalidixic acid in Salmonella enterica serovar Typhi in Central India |
| title_short | High Level of Resistance to nalidixic acid in Salmonella enterica serovar Typhi in Central India |
| title_sort | high level of resistance to nalidixic acid in salmonella enterica serovar typhi in central india |
| topic | nalidixic acid resistance Salmonella Typhi India |
| url | https://jidc.org/index.php/journal/article/view/419 |
| work_keys_str_mv | AT yashwantkumar highlevelofresistancetonalidixicacidinsalmonellaentericaserovartyphiincentralindia AT anshusharma highlevelofresistancetonalidixicacidinsalmonellaentericaserovartyphiincentralindia AT kavarattyrajumani highlevelofresistancetonalidixicacidinsalmonellaentericaserovartyphiincentralindia |