Nanoclay gels attenuate BMP2-associated inflammation and promote chondrogenesis to enhance BMP2-spinal fusion

Nanoclay gels attenuate BMP2-associated inflammation and promote chondrogenesis to enhance BMP2-spinal fusion

Bone morphogenetic protein 2 (BMP2) is clinically applied for treating intractable fractures and promoting spinal fusion because of its osteogenic potency. However, adverse effects following the release of supraphysiological doses of BMP2 from collagen carriers are widely reported. Nanoclay gel (NC)...

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Bibliographic Details
Main Authors: Takuya Furuichi, Hiromasa Hirai, Takayuki Kitahara, Masayuki Bun, Masato Ikuta, Yuichiro Ukon, Masayuki Furuya, Richard O.C. Oreffo, Agnieszka A. Janeczek, Jonathan I. Dawson, Seiji Okada, Takashi Kaito
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-02-01
Series:Bioactive Materials
Subjects:
Nanoclay
Bone morphogenetic protein 2
Endochondral ossification
Inflammation
Bone tissue engineering
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X24004808
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