A Clinical Study on the Efficacy of Acupuncture Treatment in Essential Hypertension: Protocol for Randomized Controlled Trial
BackgroundPrimary hypertension represents a significant global public health issue and is a major risk factor for severe cardiovascular disease complications. Previous research has indicated that acupuncture, as a relatively safe therapeutic approach, effectively reduces bloo...
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JMIR Publications
2025-05-01
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| Series: | JMIR Research Protocols |
| Online Access: | https://www.researchprotocols.org/2025/1/e71850 |
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| author | Xiaomin Hao Lili Zhang Yu Gong Jun Wang Weilan Qin Xudong Zhang Qiulei Guo Meng Xu Taotao Lv Yan Guo Yu Liu Jipeng Liu Bingnan Yue Qingguo Liu |
| author_facet | Xiaomin Hao Lili Zhang Yu Gong Jun Wang Weilan Qin Xudong Zhang Qiulei Guo Meng Xu Taotao Lv Yan Guo Yu Liu Jipeng Liu Bingnan Yue Qingguo Liu |
| author_sort | Xiaomin Hao |
| collection | DOAJ |
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BackgroundPrimary hypertension represents a significant global public health issue and is a major risk factor for severe cardiovascular disease complications. Previous research has indicated that acupuncture, as a relatively safe therapeutic approach, effectively reduces blood pressure and alleviates clinical symptoms.
ObjectiveThis study aims to assess the clinical efficacy and safety of the “HuoXueSanFeng” acupuncture technique in patients with essential hypertension.
MethodsThis investigation is designed as a multicenter, randomized, single-blind, sham-controlled clinical trial. A total of 228 participants with essential hypertension will be recruited from 5 tertiary hospitals in China. Participants will be randomly allocated to either the acupuncture group or the sham acupuncture group in a 1:1 ratio. Each participant will undergo treatment 3 times per week over a 6-week period, amounting to 18 sessions in total. Follow-up assessments will be conducted at 1, 2, and 4 weeks post treatment. The primary outcome measures include 24-hour ambulatory blood pressure and immediate in-office blood pressure readings. Secondary outcome measures included the Dizziness Handicap Inventory, the Headache Impact Test-6, and the Pittsburgh Sleep Quality Index. In addition, any adverse events will be documented throughout the study to assess safety.
ResultsThis study was registered with the China Clinical Trial Registration Center on May 23, 2024. Data collection commenced in July 2024 and is anticipated to conclude in June 2025. Currently, the study is in the data collection phase, with 27 participants recruited, and data analysis has yet to be conducted. The findings of this study are expected to be submitted for publication in November 2025.
ConclusionsThe outcomes of this study are anticipated to further elucidate the benefits of acupuncture in reducing blood pressure and to provide more robust evidence for the treatment of essential hypertension using the “HuoXueSanFeng” acupuncture method.
Trial RegistrationChinese Clinical Trial Registry ChiCTR2400084696; https://www.chictr.org.cn/showprojEN.html?proj=229194
International Registered Report Identifier (IRRID)DERR1-10.2196/71850 |
| format | Article |
| id | doaj-art-cdf89f2583674b9cad10a62ee82bd1ca |
| institution | Kabale University |
| issn | 1929-0748 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | JMIR Publications |
| record_format | Article |
| series | JMIR Research Protocols |
| spelling | doaj-art-cdf89f2583674b9cad10a62ee82bd1ca2025-08-20T03:53:52ZengJMIR PublicationsJMIR Research Protocols1929-07482025-05-0114e7185010.2196/71850A Clinical Study on the Efficacy of Acupuncture Treatment in Essential Hypertension: Protocol for Randomized Controlled TrialXiaomin Haohttps://orcid.org/0009-0004-8790-7832Lili Zhanghttps://orcid.org/0000-0003-0935-4991Yu Gonghttps://orcid.org/0000-0002-3794-8562Jun Wanghttps://orcid.org/0000-0001-5626-5700Weilan Qinhttps://orcid.org/0000-0002-6339-193XXudong Zhanghttps://orcid.org/0000-0003-1025-1631Qiulei Guohttps://orcid.org/0000-0002-6262-1983Meng Xuhttps://orcid.org/0000-0003-3070-0123Taotao Lvhttps://orcid.org/0000-0002-8874-7592Yan Guohttps://orcid.org/0000-0002-4379-3982Yu Liuhttps://orcid.org/0009-0002-9673-2689Jipeng Liuhttps://orcid.org/0009-0004-5217-9169Bingnan Yuehttps://orcid.org/0009-0004-6750-9626Qingguo Liuhttps://orcid.org/0000-0003-4271-1639 BackgroundPrimary hypertension represents a significant global public health issue and is a major risk factor for severe cardiovascular disease complications. Previous research has indicated that acupuncture, as a relatively safe therapeutic approach, effectively reduces blood pressure and alleviates clinical symptoms. ObjectiveThis study aims to assess the clinical efficacy and safety of the “HuoXueSanFeng” acupuncture technique in patients with essential hypertension. MethodsThis investigation is designed as a multicenter, randomized, single-blind, sham-controlled clinical trial. A total of 228 participants with essential hypertension will be recruited from 5 tertiary hospitals in China. Participants will be randomly allocated to either the acupuncture group or the sham acupuncture group in a 1:1 ratio. Each participant will undergo treatment 3 times per week over a 6-week period, amounting to 18 sessions in total. Follow-up assessments will be conducted at 1, 2, and 4 weeks post treatment. The primary outcome measures include 24-hour ambulatory blood pressure and immediate in-office blood pressure readings. Secondary outcome measures included the Dizziness Handicap Inventory, the Headache Impact Test-6, and the Pittsburgh Sleep Quality Index. In addition, any adverse events will be documented throughout the study to assess safety. ResultsThis study was registered with the China Clinical Trial Registration Center on May 23, 2024. Data collection commenced in July 2024 and is anticipated to conclude in June 2025. Currently, the study is in the data collection phase, with 27 participants recruited, and data analysis has yet to be conducted. The findings of this study are expected to be submitted for publication in November 2025. ConclusionsThe outcomes of this study are anticipated to further elucidate the benefits of acupuncture in reducing blood pressure and to provide more robust evidence for the treatment of essential hypertension using the “HuoXueSanFeng” acupuncture method. Trial RegistrationChinese Clinical Trial Registry ChiCTR2400084696; https://www.chictr.org.cn/showprojEN.html?proj=229194 International Registered Report Identifier (IRRID)DERR1-10.2196/71850https://www.researchprotocols.org/2025/1/e71850 |
| spellingShingle | Xiaomin Hao Lili Zhang Yu Gong Jun Wang Weilan Qin Xudong Zhang Qiulei Guo Meng Xu Taotao Lv Yan Guo Yu Liu Jipeng Liu Bingnan Yue Qingguo Liu A Clinical Study on the Efficacy of Acupuncture Treatment in Essential Hypertension: Protocol for Randomized Controlled Trial JMIR Research Protocols |
| title | A Clinical Study on the Efficacy of Acupuncture Treatment in Essential Hypertension: Protocol for Randomized Controlled Trial |
| title_full | A Clinical Study on the Efficacy of Acupuncture Treatment in Essential Hypertension: Protocol for Randomized Controlled Trial |
| title_fullStr | A Clinical Study on the Efficacy of Acupuncture Treatment in Essential Hypertension: Protocol for Randomized Controlled Trial |
| title_full_unstemmed | A Clinical Study on the Efficacy of Acupuncture Treatment in Essential Hypertension: Protocol for Randomized Controlled Trial |
| title_short | A Clinical Study on the Efficacy of Acupuncture Treatment in Essential Hypertension: Protocol for Randomized Controlled Trial |
| title_sort | clinical study on the efficacy of acupuncture treatment in essential hypertension protocol for randomized controlled trial |
| url | https://www.researchprotocols.org/2025/1/e71850 |
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