Myonectin, irisin, apelin-13 and Elabela hormones levels as biomarkers for type 2 diabetes mellitus : a systematic review
Insulin resistance is thought to be a key pathophysiologic indicator underlying type 2 diabetes mellitus. Nevertheless, its pathophysiology is complex and remains uncertain. Myokines such as myonectin and irisin produced by muscle tissue were shown to impact the sensitivity to insulin and could play...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2024-08-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2024/07/Al-Rubaye_96_4.pdf |
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| Summary: | Insulin resistance is thought to be a key pathophysiologic indicator underlying type 2 diabetes mellitus. Nevertheless, its pathophysiology is complex and remains uncertain. Myokines such as myonectin and irisin produced by muscle tissue were shown to impact the sensitivity to insulin and could play an essential role in the etiology of insulin resistance. Apelin and Elabela are endogenous peptide ligands of the angiotensin II protein J receptor (APJ) that are actively involved in the control of lipid and glucose metabolism, implying a vital role in the management of metabolic conditions like type 2 diabetes. In this review, the data on the level of myonectin, irisin, apelin-13 and Elabela in patients with type 2 diabetes mellitus were analyzed. |
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| ISSN: | 2409-4943 2413-5003 |