Ultrasound Real-Time Tissue Elastography Improves the Diagnostic Performance of the ACR Thyroid Imaging Reporting and Data System in Differentiating Malignant from Benign Thyroid Nodules: A Summary of 1525 Thyroid Nodules
Background. To explore the correlation between the ultrasound elasticity score (ES) of real-time tissue elastography (RTE) and the malignant risk stratification of the Thyroid Imaging Reporting and Data System (TI-RADS) and to evaluate the added value of RTE to TI-RADS in differentiating malignant n...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/1749351 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849695715799859200 |
|---|---|
| author | Shufang Pei Bin Zhang Shuzhen Cong Juanjuan Liu Suqing Wu Yuhao Dong Lu Zhang Shuixing Zhang |
| author_facet | Shufang Pei Bin Zhang Shuzhen Cong Juanjuan Liu Suqing Wu Yuhao Dong Lu Zhang Shuixing Zhang |
| author_sort | Shufang Pei |
| collection | DOAJ |
| description | Background. To explore the correlation between the ultrasound elasticity score (ES) of real-time tissue elastography (RTE) and the malignant risk stratification of the Thyroid Imaging Reporting and Data System (TI-RADS) and to evaluate the added value of RTE to TI-RADS in differentiating malignant nodules from benign ones. Methods. A total of 1,498 patients (885 women and 613 men; mean age of 43.5 ± 12.4 years) with 1,525 confirmed thyroid nodules (D = maximum diameter, D ≤ 2.5 cm) confirmed by fine-needle aspiration (FNA) and/or surgery were included. The nodules were divided into four groups based on their sizes (D ≤ 0.5 cm, 0.5 < D ≤ 1.0 cm, 1.0 < D ≤ 2.0 cm, and 2.0 < D ≤ 2.5 cm). We assigned an ES of RTE and malignant risk stratification of the TI-RADS category to each nodule. The correlation between the ES of RTE and the malignant risk stratification of TI-RADS category was analyzed by the Spearman’s rank correlation. The diagnostic performances of RTE, TI-RADS, and their combination were compared by the receiver operator characteristic (ROC) analysis. Results. The ES of RTE and the malignant risk stratification of TI-RADS showed a strong correlation in the size intervals of 0.5 < D ≤ 1.0 cm, 1.0 < D ≤ 2.0 cm, and 2.0 < D ≤ 2.5 cm (r = 0.768, 0.711, and 0.743, respectively). The diagnostic performance of their combination for each size interval was always better than RTE or TI-RADS alone (for all, P<0.001). Conclusions. Overall, The ES of RTE was strongly correlated with the malignant risk stratification of TI-RADS. The diagnostic performance of the combination of RTE and TI-RADS outperformed RTE or TI-RADS alone. Therefore, RTE may be an adjunctive tool to the current TI-RADS system for differentiating malignant from benign thyroid nodules. |
| format | Article |
| id | doaj-art-cdf545d7b00646e9b6436e25d36c466e |
| institution | DOAJ |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-cdf545d7b00646e9b6436e25d36c466e2025-08-20T03:19:41ZengWileyInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/17493511749351Ultrasound Real-Time Tissue Elastography Improves the Diagnostic Performance of the ACR Thyroid Imaging Reporting and Data System in Differentiating Malignant from Benign Thyroid Nodules: A Summary of 1525 Thyroid NodulesShufang Pei0Bin Zhang1Shuzhen Cong2Juanjuan Liu3Suqing Wu4Yuhao Dong5Lu Zhang6Shuixing Zhang7Department of Ultrasound, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, ChinaDepartment of Radiology, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, ChinaDepartment of Ultrasound, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, ChinaDepartment of Ultrasound, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, ChinaDepartment of Ultrasound, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, ChinaDepartment of Radiology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, ChinaDepartment of Radiology, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, ChinaDepartment of Radiology, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, ChinaBackground. To explore the correlation between the ultrasound elasticity score (ES) of real-time tissue elastography (RTE) and the malignant risk stratification of the Thyroid Imaging Reporting and Data System (TI-RADS) and to evaluate the added value of RTE to TI-RADS in differentiating malignant nodules from benign ones. Methods. A total of 1,498 patients (885 women and 613 men; mean age of 43.5 ± 12.4 years) with 1,525 confirmed thyroid nodules (D = maximum diameter, D ≤ 2.5 cm) confirmed by fine-needle aspiration (FNA) and/or surgery were included. The nodules were divided into four groups based on their sizes (D ≤ 0.5 cm, 0.5 < D ≤ 1.0 cm, 1.0 < D ≤ 2.0 cm, and 2.0 < D ≤ 2.5 cm). We assigned an ES of RTE and malignant risk stratification of the TI-RADS category to each nodule. The correlation between the ES of RTE and the malignant risk stratification of TI-RADS category was analyzed by the Spearman’s rank correlation. The diagnostic performances of RTE, TI-RADS, and their combination were compared by the receiver operator characteristic (ROC) analysis. Results. The ES of RTE and the malignant risk stratification of TI-RADS showed a strong correlation in the size intervals of 0.5 < D ≤ 1.0 cm, 1.0 < D ≤ 2.0 cm, and 2.0 < D ≤ 2.5 cm (r = 0.768, 0.711, and 0.743, respectively). The diagnostic performance of their combination for each size interval was always better than RTE or TI-RADS alone (for all, P<0.001). Conclusions. Overall, The ES of RTE was strongly correlated with the malignant risk stratification of TI-RADS. The diagnostic performance of the combination of RTE and TI-RADS outperformed RTE or TI-RADS alone. Therefore, RTE may be an adjunctive tool to the current TI-RADS system for differentiating malignant from benign thyroid nodules.http://dx.doi.org/10.1155/2020/1749351 |
| spellingShingle | Shufang Pei Bin Zhang Shuzhen Cong Juanjuan Liu Suqing Wu Yuhao Dong Lu Zhang Shuixing Zhang Ultrasound Real-Time Tissue Elastography Improves the Diagnostic Performance of the ACR Thyroid Imaging Reporting and Data System in Differentiating Malignant from Benign Thyroid Nodules: A Summary of 1525 Thyroid Nodules International Journal of Endocrinology |
| title | Ultrasound Real-Time Tissue Elastography Improves the Diagnostic Performance of the ACR Thyroid Imaging Reporting and Data System in Differentiating Malignant from Benign Thyroid Nodules: A Summary of 1525 Thyroid Nodules |
| title_full | Ultrasound Real-Time Tissue Elastography Improves the Diagnostic Performance of the ACR Thyroid Imaging Reporting and Data System in Differentiating Malignant from Benign Thyroid Nodules: A Summary of 1525 Thyroid Nodules |
| title_fullStr | Ultrasound Real-Time Tissue Elastography Improves the Diagnostic Performance of the ACR Thyroid Imaging Reporting and Data System in Differentiating Malignant from Benign Thyroid Nodules: A Summary of 1525 Thyroid Nodules |
| title_full_unstemmed | Ultrasound Real-Time Tissue Elastography Improves the Diagnostic Performance of the ACR Thyroid Imaging Reporting and Data System in Differentiating Malignant from Benign Thyroid Nodules: A Summary of 1525 Thyroid Nodules |
| title_short | Ultrasound Real-Time Tissue Elastography Improves the Diagnostic Performance of the ACR Thyroid Imaging Reporting and Data System in Differentiating Malignant from Benign Thyroid Nodules: A Summary of 1525 Thyroid Nodules |
| title_sort | ultrasound real time tissue elastography improves the diagnostic performance of the acr thyroid imaging reporting and data system in differentiating malignant from benign thyroid nodules a summary of 1525 thyroid nodules |
| url | http://dx.doi.org/10.1155/2020/1749351 |
| work_keys_str_mv | AT shufangpei ultrasoundrealtimetissueelastographyimprovesthediagnosticperformanceoftheacrthyroidimagingreportinganddatasystemindifferentiatingmalignantfrombenignthyroidnodulesasummaryof1525thyroidnodules AT binzhang ultrasoundrealtimetissueelastographyimprovesthediagnosticperformanceoftheacrthyroidimagingreportinganddatasystemindifferentiatingmalignantfrombenignthyroidnodulesasummaryof1525thyroidnodules AT shuzhencong ultrasoundrealtimetissueelastographyimprovesthediagnosticperformanceoftheacrthyroidimagingreportinganddatasystemindifferentiatingmalignantfrombenignthyroidnodulesasummaryof1525thyroidnodules AT juanjuanliu ultrasoundrealtimetissueelastographyimprovesthediagnosticperformanceoftheacrthyroidimagingreportinganddatasystemindifferentiatingmalignantfrombenignthyroidnodulesasummaryof1525thyroidnodules AT suqingwu ultrasoundrealtimetissueelastographyimprovesthediagnosticperformanceoftheacrthyroidimagingreportinganddatasystemindifferentiatingmalignantfrombenignthyroidnodulesasummaryof1525thyroidnodules AT yuhaodong ultrasoundrealtimetissueelastographyimprovesthediagnosticperformanceoftheacrthyroidimagingreportinganddatasystemindifferentiatingmalignantfrombenignthyroidnodulesasummaryof1525thyroidnodules AT luzhang ultrasoundrealtimetissueelastographyimprovesthediagnosticperformanceoftheacrthyroidimagingreportinganddatasystemindifferentiatingmalignantfrombenignthyroidnodulesasummaryof1525thyroidnodules AT shuixingzhang ultrasoundrealtimetissueelastographyimprovesthediagnosticperformanceoftheacrthyroidimagingreportinganddatasystemindifferentiatingmalignantfrombenignthyroidnodulesasummaryof1525thyroidnodules |