Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain

Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain

Summary: Macroautophagy (autophagy) involves the formation of phagophores that mature into autophagosomes. The impact of inhibiting autophagosome closure remains unclear. Here, we report the generation and analysis of mice with impaired autophagosome closure by targeting the ubiquitin E2 variant-lik...

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Bibliographic Details
Main Authors: Kouta Hamamoto, Xinwen Liang, Ayako Ito, Matthew Lanza, Van Bui, Jiawen Zhang, David M. Opozda, Tatsuya Hattori, Longgui Chen, David Haddock, Fumiaki Imamura, Hong-Gang Wang, Yoshinori Takahashi
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Cell Reports
Subjects:
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724013676
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