Sex differences of the lipid profile, impulsivity and suicidality in psychiatric inpatients
IntroductionEffective management of suicidality and impulsivity in hospitalized psychiatric patients is vital for improving outcomes and ensuring safety. Psychiatric patients, especially those with schizophrenia, exhibit higher tendencies towards aggressive and suicidal behaviours. This study aims t...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1595783/full |
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| author | Evanthia Bella Vasilios Kafetzopoulos Andreas Chatzittofis Andreas Chatzittofis |
| author_facet | Evanthia Bella Vasilios Kafetzopoulos Andreas Chatzittofis Andreas Chatzittofis |
| author_sort | Evanthia Bella |
| collection | DOAJ |
| description | IntroductionEffective management of suicidality and impulsivity in hospitalized psychiatric patients is vital for improving outcomes and ensuring safety. Psychiatric patients, especially those with schizophrenia, exhibit higher tendencies towards aggressive and suicidal behaviours. This study aims to explore sex-specific associations between lipid profiles, impulsivity, and suicidality among psychiatric inpatients.MethodsA total of 158 psychiatric inpatients (92 men and 66 women) were assessed using the Barratt Impulsiveness Scale, the Columbia Suicide Severity Rating Scale, and the Karolinska Interpersonal Violence Scale. Serum lipid levels (total cholesterol, LDL, HDL) were obtained from fasting blood samples.ResultsAmong men, higher total cholesterol and LDL were positively correlated with impulsivity (LDL and BIS-11 total score: rho = .308, p = .006). In women, higher HDL was associated with lower suicidality (HDL and lifetime suicide attempt frequency: rho = –.374, p = .021). Regression confirmed LDL predicts impulsivity in men (R squared = .265, p = .031), and HDL, LDL, age, and BMI explain 52 percent of suicidality variance in women (R squared = .523, p = .0006).ConclusionElevated LDL may indicate higher impulsivity in men, while low HDL suggests higher suicide risk in women. Lipid monitoring could enhance risk assessment in psychiatric care. |
| format | Article |
| id | doaj-art-cdf3c333cc2d4976a3c400573f0515b4 |
| institution | OA Journals |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj-art-cdf3c333cc2d4976a3c400573f0515b42025-08-20T01:52:19ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-05-011610.3389/fpsyt.2025.15957831595783Sex differences of the lipid profile, impulsivity and suicidality in psychiatric inpatientsEvanthia Bella0Vasilios Kafetzopoulos1Andreas Chatzittofis2Andreas Chatzittofis3Medical School, University of Cyprus, Nicosia, CyprusMedical School, University of Cyprus, Nicosia, CyprusMedical School, University of Cyprus, Nicosia, CyprusDepartment of Clinical Sciences/Psychiatry, Umeå University, Umeå, SwedenIntroductionEffective management of suicidality and impulsivity in hospitalized psychiatric patients is vital for improving outcomes and ensuring safety. Psychiatric patients, especially those with schizophrenia, exhibit higher tendencies towards aggressive and suicidal behaviours. This study aims to explore sex-specific associations between lipid profiles, impulsivity, and suicidality among psychiatric inpatients.MethodsA total of 158 psychiatric inpatients (92 men and 66 women) were assessed using the Barratt Impulsiveness Scale, the Columbia Suicide Severity Rating Scale, and the Karolinska Interpersonal Violence Scale. Serum lipid levels (total cholesterol, LDL, HDL) were obtained from fasting blood samples.ResultsAmong men, higher total cholesterol and LDL were positively correlated with impulsivity (LDL and BIS-11 total score: rho = .308, p = .006). In women, higher HDL was associated with lower suicidality (HDL and lifetime suicide attempt frequency: rho = –.374, p = .021). Regression confirmed LDL predicts impulsivity in men (R squared = .265, p = .031), and HDL, LDL, age, and BMI explain 52 percent of suicidality variance in women (R squared = .523, p = .0006).ConclusionElevated LDL may indicate higher impulsivity in men, while low HDL suggests higher suicide risk in women. Lipid monitoring could enhance risk assessment in psychiatric care.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1595783/fullimpulsivitysuicidalitysuicideHDLLDLlipids |
| spellingShingle | Evanthia Bella Vasilios Kafetzopoulos Andreas Chatzittofis Andreas Chatzittofis Sex differences of the lipid profile, impulsivity and suicidality in psychiatric inpatients Frontiers in Psychiatry impulsivity suicidality suicide HDL LDL lipids |
| title | Sex differences of the lipid profile, impulsivity and suicidality in psychiatric inpatients |
| title_full | Sex differences of the lipid profile, impulsivity and suicidality in psychiatric inpatients |
| title_fullStr | Sex differences of the lipid profile, impulsivity and suicidality in psychiatric inpatients |
| title_full_unstemmed | Sex differences of the lipid profile, impulsivity and suicidality in psychiatric inpatients |
| title_short | Sex differences of the lipid profile, impulsivity and suicidality in psychiatric inpatients |
| title_sort | sex differences of the lipid profile impulsivity and suicidality in psychiatric inpatients |
| topic | impulsivity suicidality suicide HDL LDL lipids |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1595783/full |
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